JP7798881B2 - アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法 - Google Patents

アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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Publication number
JP7798881B2
JP7798881B2 JP2023526961A JP2023526961A JP7798881B2 JP 7798881 B2 JP7798881 B2 JP 7798881B2 JP 2023526961 A JP2023526961 A JP 2023526961A JP 2023526961 A JP2023526961 A JP 2023526961A JP 7798881 B2 JP7798881 B2 JP 7798881B2
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rnai construct
patient
lpa rnai
pharmaceutical composition
lpa
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JP2023549115A (ja
JP2023549115A5 (https=
Inventor
ウィニー ソーン，
ザカリー ジョーンズ，
ヘリナ カサフン，
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Amgen Inc
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Amgen Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61P3/06—Antihyperlipidemics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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JP2023526961A 2020-11-05 2021-11-04 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法 Active JP7798881B2 (ja)

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JP2024192703A JP2025016670A (ja) 2020-11-05 2024-11-01 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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US202063110309P 2020-11-05 2020-11-05
US63/110,309 2020-11-05
PCT/US2021/058012 WO2022098841A1 (en) 2020-11-05 2021-11-04 METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS

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JP2023549115A5 JP2023549115A5 (https=) 2024-11-12
JP7798881B2 true JP7798881B2 (ja) 2026-01-14

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JP2024192703A Pending JP2025016670A (ja) 2020-11-05 2024-11-01 アテローム硬化性心血管疾患をＬＰＡ標的ＲＮＡｉ構築体により処置する方法

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US (1) US20230405040A1 (https=)
EP (1) EP4240855A1 (https=)
JP (2) JP7798881B2 (https=)
KR (1) KR20230104200A (https=)
CN (1) CN116456990A (https=)
AU (1) AU2021373780A1 (https=)
CA (1) CA3199678A1 (https=)
IL (1) IL302330A (https=)
JO (1) JOP20230093A1 (https=)
MX (1) MX2023005198A (https=)
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CN115851723B (zh) * 2022-10-24 2023-10-03 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用
US20240226049A1 (en) * 2023-01-09 2024-07-11 Esperion Therapeutics, Inc. Methods of treatment using bempedoic acid
WO2024151937A1 (en) * 2023-01-13 2024-07-18 Eli Lilly And Company Therapeutic oligonucleotide-containing pharmaceutical compositions and dosing regimens using the same
CN120693405A (zh) * 2023-02-03 2025-09-23 诺华股份有限公司 降低一级预防受试者中重大不良心血管事件风险的方法
KR20260013486A (ko) * 2023-05-24 2026-01-28 씨엠에스 리서치 앤드 디벨롭먼트 피티이. 리미티드 이중 가닥 sirna, 그의 접합체 및 그의 용도
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
WO2025252223A1 (zh) * 2024-06-07 2025-12-11 迈威(上海)生物科技股份有限公司 一种抑制PCSK9基因表达的RNAi制剂及其应用

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