JP7788208B2 - キナーゼネットワークの阻害剤およびその使用 - Google Patents

キナーゼネットワークの阻害剤およびその使用

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Publication number
JP7788208B2
JP7788208B2 JP2019552978A JP2019552978A JP7788208B2 JP 7788208 B2 JP7788208 B2 JP 7788208B2 JP 2019552978 A JP2019552978 A JP 2019552978A JP 2019552978 A JP2019552978 A JP 2019552978A JP 7788208 B2 JP7788208 B2 JP 7788208B2
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Prior art keywords
tetrahydro
pyrazolo
phenanthridine
phenanthridin
pyrrolo
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Japanese (ja)
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JP2020523282A5 (cg-RX-API-DMAC7.html
JP2020523282A (ja
Inventor
オー． シンティム、ハーマン
ダヤル、ネートゥ
－ テメン、クレメント オポク
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パデュー リサーチ ファウンデイション
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Publication of JP2020523282A5 publication Critical patent/JP2020523282A5/ja
Priority to JP2022027439A priority Critical patent/JP2022081529A/ja
Priority to JP2022150644A priority patent/JP7668254B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019552978A 2017-03-29 2018-03-29 キナーゼネットワークの阻害剤およびその使用 Active JP7788208B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022027439A JP2022081529A (ja) 2017-03-29 2022-02-25 キナーゼネットワークの阻害剤およびその使用
JP2022150644A JP7668254B2 (ja) 2017-03-29 2022-09-21 キナーゼネットワークの阻害剤およびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762478069P 2017-03-29 2017-03-29
US62/478,069 2017-03-29
US201862616643P 2018-01-12 2018-01-12
US62/616,643 2018-01-12
PCT/US2018/024991 WO2018183586A1 (en) 2017-03-29 2018-03-29 Inhibitors of kinase networks and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022027439A Division JP2022081529A (ja) 2017-03-29 2022-02-25 キナーゼネットワークの阻害剤およびその使用
JP2022150644A Division JP7668254B2 (ja) 2017-03-29 2022-09-21 キナーゼネットワークの阻害剤およびその使用

Publications (3)

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JP2020523282A JP2020523282A (ja) 2020-08-06
JP2020523282A5 JP2020523282A5 (cg-RX-API-DMAC7.html) 2020-09-17
JP7788208B2 true JP7788208B2 (ja) 2025-12-18

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JP2019552978A Active JP7788208B2 (ja) 2017-03-29 2018-03-29 キナーゼネットワークの阻害剤およびその使用
JP2022027439A Pending JP2022081529A (ja) 2017-03-29 2022-02-25 キナーゼネットワークの阻害剤およびその使用
JP2022150644A Active JP7668254B2 (ja) 2017-03-29 2022-09-21 キナーゼネットワークの阻害剤およびその使用

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JP2022027439A Pending JP2022081529A (ja) 2017-03-29 2022-02-25 キナーゼネットワークの阻害剤およびその使用
JP2022150644A Active JP7668254B2 (ja) 2017-03-29 2022-09-21 キナーゼネットワークの阻害剤およびその使用

Country Status (6)

Country Link
US (3) US11040973B2 (cg-RX-API-DMAC7.html)
EP (2) EP4233859A1 (cg-RX-API-DMAC7.html)
JP (3) JP7788208B2 (cg-RX-API-DMAC7.html)
CN (1) CN110662536B (cg-RX-API-DMAC7.html)
CA (1) CA3056641A1 (cg-RX-API-DMAC7.html)
WO (1) WO2018183586A1 (cg-RX-API-DMAC7.html)

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CA3056641A1 (en) * 2017-03-29 2018-10-04 Purdue Research Foundation Inhibitors of kinase networks and uses thereof
TWI802635B (zh) 2018-01-18 2023-05-21 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物
WO2019143994A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CA3117710A1 (en) 2018-12-11 2020-06-18 Theravance Biopharma R&D Ip, Llc Alk5 inhibitors
WO2021061823A1 (en) * 2019-09-23 2021-04-01 Boragen, Inc. Chemical compounds
CA3160307A1 (en) 2019-11-22 2021-05-27 Theravance Biopharma R&D Ip, Llc Substituted 1,5-naphthyridines or quinolines as alk5 inhibitors
CN113214294A (zh) * 2020-06-10 2021-08-06 深圳铂立健医药有限公司 三环化合物、药物组合物及其应用
US20230312562A1 (en) * 2020-07-02 2023-10-05 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline -containing compounds and uses thereof
CN116903594A (zh) * 2022-04-20 2023-10-20 上海挚盟医药科技有限公司 Rho相关蛋白激酶抑制剂及其制备和应用
CN117186002A (zh) * 2022-05-31 2023-12-08 江苏亚虹医药科技股份有限公司 7-氰基-8-羟基喹啉衍生物、其制备方法及其医药用途
CN119301099A (zh) * 2022-06-02 2025-01-10 普渡研究基金会 4-(3H-吡唑并[4,3-f]喹啉-7-基)-N-(2-(二甲基氨基)乙基)苯甲酰胺或异羟肟酸化合物、组合物及使用方法
WO2024206164A1 (en) * 2023-03-24 2024-10-03 Purdue Research Foundation 3H-PYRAZOLO[4.3:f] QUINOLINE-BASED COMPOUNDS AS STING ANTAGONISTS

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JP2002542193A (ja) 1999-04-15 2002-12-10 ブリストル−マイヤーズ スクイブ カンパニー 環状タンパク質チロシンキナーゼ阻害剤
WO2011043359A1 (ja) 2009-10-06 2011-04-14 協和発酵キリン株式会社 芳香族複素環化合物を含有する医薬
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
WO2016112284A1 (en) 2015-01-09 2016-07-14 Genentech, Inc. (piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer

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EP0187705A3 (en) * 1985-01-08 1988-05-11 Norwich Eaton Pharmaceuticals, Inc. Imidazo(4,5-f)quinolines useful as immunomodulating agents
WO1993022317A1 (fr) 1992-05-01 1993-11-11 Kowa Co., Ltd. Derive de quinoline ou son sel et medicament contenant ledit derive pour maladies cardiaques
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JP2002542193A (ja) 1999-04-15 2002-12-10 ブリストル−マイヤーズ スクイブ カンパニー 環状タンパク質チロシンキナーゼ阻害剤
WO2011043359A1 (ja) 2009-10-06 2011-04-14 協和発酵キリン株式会社 芳香族複素環化合物を含有する医薬
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
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Also Published As

Publication number Publication date
CN110662536B (zh) 2023-06-23
CA3056641A1 (en) 2018-10-04
JP2022081529A (ja) 2022-05-31
JP2020523282A (ja) 2020-08-06
JP2022191259A (ja) 2022-12-27
WO2018183586A1 (en) 2018-10-04
CN110662536A (zh) 2020-01-07
EP4233859A1 (en) 2023-08-30
US11891391B2 (en) 2024-02-06
US12384782B2 (en) 2025-08-12
EP3600287B1 (en) 2023-07-05
US20210371420A1 (en) 2021-12-02
EP3600287A1 (en) 2020-02-05
US20200308173A1 (en) 2020-10-01
US11040973B2 (en) 2021-06-22
EP3600287A4 (en) 2021-03-31
JP7668254B2 (ja) 2025-04-24
US20240208971A1 (en) 2024-06-27

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