JP7783176B2 - メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム - Google Patents

メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム

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Publication number
JP7783176B2
JP7783176B2 JP2022529847A JP2022529847A JP7783176B2 JP 7783176 B2 JP7783176 B2 JP 7783176B2 JP 2022529847 A JP2022529847 A JP 2022529847A JP 2022529847 A JP2022529847 A JP 2022529847A JP 7783176 B2 JP7783176 B2 JP 7783176B2
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nucleic acid
subset
acid molecules
methylated
carrier nucleic
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JP2023502752A5 (https=
JP2023502752A (ja
Inventor
ダスティン ハワード ハイト，
ファルシード ガディリ，
ステファニー アン ウォード モーティマー，
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ガーダント ヘルス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022529847A 2019-11-26 2020-11-25 メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム Active JP7783176B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025207226A JP2026035733A (ja) 2019-11-26 2025-11-27 メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940853P 2019-11-26 2019-11-26
US62/940,853 2019-11-26
PCT/US2020/062419 WO2021108708A1 (en) 2019-11-26 2020-11-25 Methods, compositions and systems for improving the binding of methylated polynucleotides

Related Child Applications (1)

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JP2025207226A Division JP2026035733A (ja) 2019-11-26 2025-11-27 メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム

Publications (3)

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JP2023502752A JP2023502752A (ja) 2023-01-25
JP2023502752A5 JP2023502752A5 (https=) 2023-12-05
JP7783176B2 true JP7783176B2 (ja) 2025-12-09

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JP2022529847A Active JP7783176B2 (ja) 2019-11-26 2020-11-25 メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム
JP2025207226A Pending JP2026035733A (ja) 2019-11-26 2025-11-27 メチル化ポリヌクレオチドの結合を改善するための方法、組成物およびシステム

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Country Status (7)

Country Link
US (1) US20210214800A1 (https=)
EP (2) EP4617375A3 (https=)
JP (2) JP7783176B2 (https=)
CN (1) CN114746560A (https=)
CA (1) CA3157560A1 (https=)
ES (1) ES3031713T3 (https=)
WO (1) WO2021108708A1 (https=)

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WO2020160414A1 (en) * 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
WO2023107709A1 (en) * 2021-12-10 2023-06-15 Adela, Inc. Methods and systems for generating sequencing libraries
WO2026060266A1 (en) * 2024-09-13 2026-03-19 Guardant Health, Inc. Use of copy number variants for the identification of false positive tumor calls

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WO2019006269A1 (en) 2017-06-30 2019-01-03 The Regents Of The University Of California METHODS AND SYSTEMS FOR ASSESSING METHYLATION OF DNA IN ACELLULAR DNA
WO2019010564A1 (en) 2017-07-12 2019-01-17 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS
JP2019521315A (ja) 2016-05-03 2019-07-25 ユニバーシティ・ヘルス・ネットワーク 無細胞メチル化ｄｎａを捕捉する方法及びその使用

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GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
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AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
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US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
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WO2003046146A2 (en) 2001-11-28 2003-06-05 Applera Corporation Compositions and methods of selective nucleic acid isolation
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JP5149013B2 (ja) * 2004-11-29 2013-02-20 セクエノム，インコーポレイティド メチル化ｄｎａを検出する手段、及び方法
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WO2019006269A1 (en) 2017-06-30 2019-01-03 The Regents Of The University Of California METHODS AND SYSTEMS FOR ASSESSING METHYLATION OF DNA IN ACELLULAR DNA
WO2019010564A1 (en) 2017-07-12 2019-01-17 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS

Also Published As

Publication number Publication date
ES3031713T3 (en) 2025-07-10
EP4065725C0 (en) 2025-05-21
EP4065725B1 (en) 2025-05-21
EP4065725A1 (en) 2022-10-05
JP2023502752A (ja) 2023-01-25
EP4617375A3 (en) 2025-10-29
CA3157560A1 (en) 2021-06-03
WO2021108708A1 (en) 2021-06-03
EP4617375A2 (en) 2025-09-17
CN114746560A (zh) 2022-07-12
JP2026035733A (ja) 2026-03-04
US20210214800A1 (en) 2021-07-15

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