CN114746560A - 改进甲基化多核苷酸结合的方法、组合物和系统 - Google Patents

改进甲基化多核苷酸结合的方法、组合物和系统 Download PDF

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Publication number
CN114746560A
CN114746560A CN202080082559.7A CN202080082559A CN114746560A CN 114746560 A CN114746560 A CN 114746560A CN 202080082559 A CN202080082559 A CN 202080082559A CN 114746560 A CN114746560 A CN 114746560A
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nucleic acid
subset
acid molecules
methylated
vector nucleic
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达斯汀·霍华德·海特
法尔希德·加迪里
斯特凡尼·安·沃德·莫蒂默
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Guardant Health Inc
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Guardant Health Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
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  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202080082559.7A 2019-11-26 2020-11-25 改进甲基化多核苷酸结合的方法、组合物和系统 Pending CN114746560A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940853P 2019-11-26 2019-11-26
US62/940,853 2019-11-26
PCT/US2020/062419 WO2021108708A1 (en) 2019-11-26 2020-11-25 Methods, compositions and systems for improving the binding of methylated polynucleotides

Publications (1)

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CN114746560A true CN114746560A (zh) 2022-07-12

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US (1) US20210214800A1 (https=)
EP (2) EP4617375A3 (https=)
JP (2) JP7783176B2 (https=)
CN (1) CN114746560A (https=)
CA (1) CA3157560A1 (https=)
ES (1) ES3031713T3 (https=)
WO (1) WO2021108708A1 (https=)

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WO2020160414A1 (en) * 2019-01-31 2020-08-06 Guardant Health, Inc. Compositions and methods for isolating cell-free dna
WO2023107709A1 (en) * 2021-12-10 2023-06-15 Adela, Inc. Methods and systems for generating sequencing libraries
WO2026060266A1 (en) * 2024-09-13 2026-03-19 Guardant Health, Inc. Use of copy number variants for the identification of false positive tumor calls

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WO2019006269A1 (en) * 2017-06-30 2019-01-03 The Regents Of The University Of California METHODS AND SYSTEMS FOR ASSESSING METHYLATION OF DNA IN ACELLULAR DNA
CN109415763A (zh) * 2016-05-03 2019-03-01 大学健康网络 捕获无细胞的甲基化dna的方法及其用途
WO2019117714A1 (en) * 2017-12-11 2019-06-20 Umc Utrecht Holding B.V. Methods for preparing nucleic acid molecules for sequencing
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JP7783176B2 (ja) 2025-12-09
ES3031713T3 (en) 2025-07-10
EP4065725C0 (en) 2025-05-21
EP4065725B1 (en) 2025-05-21
EP4065725A1 (en) 2022-10-05
JP2023502752A (ja) 2023-01-25
EP4617375A3 (en) 2025-10-29
CA3157560A1 (en) 2021-06-03
WO2021108708A1 (en) 2021-06-03
EP4617375A2 (en) 2025-09-17
JP2026035733A (ja) 2026-03-04
US20210214800A1 (en) 2021-07-15

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