JP7773154B2 - コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片 - Google Patents

コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片

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Publication number
JP7773154B2
JP7773154B2 JP2022545513A JP2022545513A JP7773154B2 JP 7773154 B2 JP7773154 B2 JP 7773154B2 JP 2022545513 A JP2022545513 A JP 2022545513A JP 2022545513 A JP2022545513 A JP 2022545513A JP 7773154 B2 JP7773154 B2 JP 7773154B2
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JP
Japan
Prior art keywords
antibody
antibodies
antigen
sars
cov
Prior art date
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Active
Application number
JP2022545513A
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English (en)
Japanese (ja)
Other versions
JPWO2022044573A1 (https=
JPWO2022044573A5 (https=
Inventor
修三 松下
悠 郭
岳夫 桑田
義裕 河岡
正樹 今井
誠也 山吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kumamoto University NUC
University of Tokyo NUC
Original Assignee
Kumamoto University NUC
University of Tokyo NUC
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Application filed by Kumamoto University NUC, University of Tokyo NUC filed Critical Kumamoto University NUC
Publication of JPWO2022044573A1 publication Critical patent/JPWO2022044573A1/ja
Publication of JPWO2022044573A5 publication Critical patent/JPWO2022044573A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
JP2022545513A 2020-08-26 2021-07-09 コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片 Active JP7773154B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2020143055 2020-08-26
JP2020143055 2020-08-26
JP2021054387 2021-03-26
JP2021054387 2021-03-26
PCT/JP2021/026053 WO2022044573A1 (ja) 2020-08-26 2021-07-09 コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片

Publications (3)

Publication Number Publication Date
JPWO2022044573A1 JPWO2022044573A1 (https=) 2022-03-03
JPWO2022044573A5 JPWO2022044573A5 (https=) 2023-06-20
JP7773154B2 true JP7773154B2 (ja) 2025-11-19

Family

ID=80353115

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022545513A Active JP7773154B2 (ja) 2020-08-26 2021-07-09 コロナウイルススパイク蛋白に対するヒト抗体またはその抗原結合断片

Country Status (4)

Country Link
US (1) US20230312689A1 (https=)
EP (1) EP4206224A4 (https=)
JP (1) JP7773154B2 (https=)
WO (1) WO2022044573A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115073594A (zh) * 2022-06-08 2022-09-20 四川大学华西医院 一种抗新冠病毒SARS-CoV-2突变株表面S2蛋白的单链抗体、制备方法及其应用
WO2024053719A1 (ja) 2022-09-08 2024-03-14 国立大学法人熊本大学 コロナウイルス変異株に対するヒト抗体またはその抗原結合断片
CN118406139A (zh) * 2022-09-30 2024-07-30 郴州市第一人民医院 一种抗新型冠状病毒SARS-CoV-2的广谱中和抗体及其应用

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK1399484T3 (da) 2001-06-28 2010-11-08 Domantis Ltd Dobbelt-specifik ligand og anvendelse af denne
AU2003244817B2 (en) 2002-06-28 2010-08-26 Domantis Limited Antigen-binding immunoglobulin single variable domains and dual-specific constructs
EP1578801A2 (en) 2002-12-27 2005-09-28 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
DE602004017726D1 (de) 2003-06-30 2008-12-24 Domantis Ltd Pegylierte Single-domain-antikörper (dAb)
CA2595780A1 (en) 2005-02-08 2006-08-17 Shibo Jiang Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
MX2008014710A (es) 2006-05-19 2009-02-12 Amgen Inc Anticuerpos para coronavirus del sars.
KR20250107297A (ko) * 2020-04-02 2025-07-11 리제너론 파아마슈티컬스, 인크. 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편
CN111647076B (zh) * 2020-04-27 2021-02-26 南京医科大学 抗新型冠状病毒SARS-Cov-2的中和性单域抗体及其应用
CN111718411B (zh) * 2020-06-19 2022-03-08 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体1F2
CN112521494B (zh) * 2020-06-19 2021-06-25 武汉生物制品研究所有限责任公司 一种抗SARS-CoV-2的单克隆抗体2B11
CN111909261B (zh) * 2020-08-19 2022-10-04 重庆医科大学 新冠病毒rbd特异性单克隆抗体和应用
WO2022155324A1 (en) * 2021-01-15 2022-07-21 The Rockefeller University Neutralizing anti-sars-cov-2 antibodies

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CAO, Y. et al.，Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells，Cell，2020年07月09日，Vol.182，p.73-84
JU, B. et al.，Human neutralizing antibodies elicited by SARS-Cov-2 infection，Nature，2020年08月06日，Vol.584，p.115-119
LIU, L. et al.，Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike，Nature，2020年08月20日，Vol.584，p.450-456
SHI, R. et al.，A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2，Nature，2020年08月06日，Vol.584，p.120-124
WAN, J. et al.，Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection，Cell Reports，2020年07月21日，Vol.32, 107918，p.1-8

Also Published As

Publication number Publication date
WO2022044573A1 (ja) 2022-03-03
JPWO2022044573A1 (https=) 2022-03-03
EP4206224A4 (en) 2025-04-02
EP4206224A1 (en) 2023-07-05
US20230312689A1 (en) 2023-10-05

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