JP7765291B2 - Ｃｄ３３標的免疫療法 - Google Patents

Ｃｄ３３標的免疫療法

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Publication number
JP7765291B2
JP7765291B2 JP2021566152A JP2021566152A JP7765291B2 JP 7765291 B2 JP7765291 B2 JP 7765291B2 JP 2021566152 A JP2021566152 A JP 2021566152A JP 2021566152 A JP2021566152 A JP 2021566152A JP 7765291 B2 JP7765291 B2 JP 7765291B2
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JP
Japan
Prior art keywords
cell
cells
polypeptide
domain
vhh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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JP2021566152A
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English (en)
Japanese (ja)
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JPWO2020227474A5 (https=
JP2022531719A5 (https=
JP2022531719A (ja
Inventor
ジョーダン ジャージョル，
マーク ポグソン，
ワイ－ハン レオン，
カイル ジョーンズ，
ウィリアム クラゴ，
アンジェリカ サナブリア，
アンドリュー ホランズ，
ジェイコブ ガノ，
ミルトン マ，
ジョン シー． ティマー，
ブレンダン ピー． エクケルマン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2022531719A publication Critical patent/JP2022531719A/ja
Publication of JPWO2020227474A5 publication Critical patent/JPWO2020227474A5/ja
Publication of JP2022531719A5 publication Critical patent/JP2022531719A5/ja
Priority to JP2025179511A priority Critical patent/JP2026021386A/ja
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/00—Fusion polypeptide
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JP2021566152A 2019-05-08 2020-05-07 Ｃｄ３３標的免疫療法 Active JP7765291B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025179511A JP2026021386A (ja) 2019-05-08 2025-10-24 Ｃｄ３３標的免疫療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962845304P 2019-05-08 2019-05-08
US62/845,304 2019-05-08
US201962898392P 2019-09-10 2019-09-10
US62/898,392 2019-09-10
PCT/US2020/031780 WO2020227474A1 (en) 2019-05-08 2020-05-07 Cd33 targeted immunotherapies

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JP2022531719A JP2022531719A (ja) 2022-07-08
JPWO2020227474A5 JPWO2020227474A5 (https=) 2023-06-23
JP2022531719A5 JP2022531719A5 (https=) 2023-06-23
JP7765291B2 true JP7765291B2 (ja) 2025-11-06

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US (1) US12552855B2 (https=)
EP (1) EP3966251A4 (https=)
JP (2) JP7765291B2 (https=)
KR (1) KR20220031554A (https=)
CN (1) CN114206928B (https=)
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