JP7760503B2 - スクアレンホペンシクラーゼ（ｓｈｃ）バリアント - Google Patents
スクアレンホペンシクラーゼ（ｓｈｃ）バリアントInfo
- Publication number
- JP7760503B2 JP7760503B2 JP2022534163A JP2022534163A JP7760503B2 JP 7760503 B2 JP7760503 B2 JP 7760503B2 JP 2022534163 A JP2022534163 A JP 2022534163A JP 2022534163 A JP2022534163 A JP 2022534163A JP 7760503 B2 JP7760503 B2 JP 7760503B2
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- shc
- hac
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025138681A JP2025188332A (ja) | 2019-12-04 | 2025-08-22 | スクアレンホペンシクラーゼ（ｓｈｃ）バリアント |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1917688.2 | 2019-12-04 | ||
| GBGB1917688.2A GB201917688D0 (en) | 2019-12-04 | 2019-12-04 | SHC enzymes and enzyme variants |
| PCT/EP2020/084491 WO2021110848A1 (en) | 2019-12-04 | 2020-12-03 | Squalene hopene cyclase (shc) variants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025138681A Division JP2025188332A (ja) | 2019-12-04 | 2025-08-22 | スクアレンホペンシクラーゼ（ｓｈｃ）バリアント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504855A JP2023504855A (ja) | 2023-02-07 |
| JP2023504855A5 JP2023504855A5 (https=) | 2023-10-16 |
| JP7760503B2 true JP7760503B2 (ja) | 2025-10-27 |
Family
ID=69147249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022534163A Active JP7760503B2 (ja) | 2019-12-04 | 2020-12-03 | スクアレンホペンシクラーゼ（ｓｈｃ）バリアント |
| JP2025138681A Pending JP2025188332A (ja) | 2019-12-04 | 2025-08-22 | スクアレンホペンシクラーゼ（ｓｈｃ）バリアント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025138681A Pending JP2025188332A (ja) | 2019-12-04 | 2025-08-22 | スクアレンホペンシクラーゼ（ｓｈｃ）バリアント |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12416027B2 (https=) |
| EP (1) | EP4069836A1 (https=) |
| JP (2) | JP7760503B2 (https=) |
| CN (1) | CN115052982A (https=) |
| BR (1) | BR112022009627A2 (https=) |
| CO (1) | CO2022008659A2 (https=) |
| GB (1) | GB201917688D0 (https=) |
| IL (1) | IL293275A (https=) |
| MX (1) | MX2022005939A (https=) |
| WO (1) | WO2021110848A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119137269A (zh) | 2022-03-17 | 2024-12-13 | 奇华顿股份有限公司 | Shc酶和酶变体 |
| WO2024112870A1 (en) * | 2022-11-23 | 2024-05-30 | Conagen Inc. | Conversion of homofarnesol to ambroxide |
| CN115851863B (zh) * | 2022-11-30 | 2023-07-25 | 北京大学深圳研究生院 | 一种海绵烷骨架化合物的制备方法及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009060799A (ja) | 2007-09-04 | 2009-03-26 | Kao Corp | （−）−アンブロキサンの製造方法 |
| JP2012528578A (ja) | 2009-06-05 | 2012-11-15 | ビーエーエスエフ ソシエタス・ヨーロピア | アンブロキサンの生物触媒的生産 |
| JP2018513691A (ja) | 2015-04-24 | 2018-05-31 | ジボダン エス エー | 酵素およびその適用 |
| WO2018157021A1 (en) | 2017-02-24 | 2018-08-30 | International Flavors & Fragrances Inc. | Squalene hopene cyclase and use thereof for producing ambroxan |
| JP2019170350A (ja) | 2018-03-30 | 2019-10-10 | 国立大学法人千葉大学 | スクアレン消費酵素のスクリーニング方法及びスクアレン−ホペン環化酵素 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19649655A1 (de) | 1996-11-29 | 1998-06-04 | Haarmann & Reimer Gmbh | Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung |
| DE19960106A1 (de) | 1999-12-14 | 2001-06-21 | Haarmann & Reimer Gmbh | Enzyme und Gene für die Herstellung von Vanillin |
| EP4112727A3 (de) | 2010-11-17 | 2023-03-15 | Basf Se | Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten |
| WO2013156398A1 (de) | 2012-04-16 | 2013-10-24 | Basf Se | Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol |
| US20130273619A1 (en) | 2012-04-16 | 2013-10-17 | Basf Se | Process for the Preparation of (3E, 7E)-Homofarnesol |
| JP5748381B1 (ja) | 2014-07-31 | 2015-07-15 | 楽天株式会社 | メッセージ処理装置、メッセージ処理方法、記録媒体およびプログラム |
| GB201507170D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Process |
| EP3816297A1 (de) * | 2016-02-19 | 2021-05-05 | Basf Se | Biokatalytische zyklisierung von mehrfach ungesättigten carbonsäuren-verbindungen |
| GB201618090D0 (en) * | 2016-10-26 | 2016-12-07 | Givaudan Sa | Product |
| GB201917694D0 (en) * | 2019-12-04 | 2020-01-15 | Givaudan Sa | Enzyme mediated process |
-
2019
- 2019-12-04 GB GBGB1917688.2A patent/GB201917688D0/en not_active Ceased
-
2020
- 2020-12-03 WO PCT/EP2020/084491 patent/WO2021110848A1/en not_active Ceased
- 2020-12-03 BR BR112022009627A patent/BR112022009627A2/pt unknown
- 2020-12-03 MX MX2022005939A patent/MX2022005939A/es unknown
- 2020-12-03 IL IL293275A patent/IL293275A/en unknown
- 2020-12-03 US US17/776,686 patent/US12416027B2/en active Active
- 2020-12-03 CN CN202080094930.1A patent/CN115052982A/zh active Pending
- 2020-12-03 JP JP2022534163A patent/JP7760503B2/ja active Active
- 2020-12-03 EP EP20820112.9A patent/EP4069836A1/en active Pending
-
2022
- 2022-06-21 CO CONC2022/0008659A patent/CO2022008659A2/es unknown
-
2025
- 2025-06-20 US US19/244,533 patent/US20250361536A1/en active Pending
- 2025-08-22 JP JP2025138681A patent/JP2025188332A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009060799A (ja) | 2007-09-04 | 2009-03-26 | Kao Corp | （−）−アンブロキサンの製造方法 |
| JP2012528578A (ja) | 2009-06-05 | 2012-11-15 | ビーエーエスエフ ソシエタス・ヨーロピア | アンブロキサンの生物触媒的生産 |
| JP2018513691A (ja) | 2015-04-24 | 2018-05-31 | ジボダン エス エー | 酵素およびその適用 |
| WO2018157021A1 (en) | 2017-02-24 | 2018-08-30 | International Flavors & Fragrances Inc. | Squalene hopene cyclase and use thereof for producing ambroxan |
| JP2019170350A (ja) | 2018-03-30 | 2019-10-10 | 国立大学法人千葉大学 | スクアレン消費酵素のスクリーニング方法及びスクアレン−ホペン環化酵素 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115052982A (zh) | 2022-09-13 |
| CO2022008659A2 (es) | 2022-07-19 |
| JP2023504855A (ja) | 2023-02-07 |
| BR112022009627A2 (pt) | 2022-08-09 |
| WO2021110848A1 (en) | 2021-06-10 |
| US12416027B2 (en) | 2025-09-16 |
| US20250361536A1 (en) | 2025-11-27 |
| IL293275A (en) | 2022-07-01 |
| MX2022005939A (es) | 2022-09-09 |
| JP2025188332A (ja) | 2025-12-26 |
| GB201917688D0 (en) | 2020-01-15 |
| US20230021613A1 (en) | 2023-01-26 |
| EP4069836A1 (en) | 2022-10-12 |
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