CN115052982A - 角鲨烯藿烯环化酶(shc)变体 - Google Patents

角鲨烯藿烯环化酶(shc)变体 Download PDF

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Publication number
CN115052982A
CN115052982A CN202080094930.1A CN202080094930A CN115052982A CN 115052982 A CN115052982 A CN 115052982A CN 202080094930 A CN202080094930 A CN 202080094930A CN 115052982 A CN115052982 A CN 115052982A
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seq
amino acid
shc
hac
hac enzyme
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CN202080094930.1A
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Chinese (zh)
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E·艾克霍恩
C·阿尔曼
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Givaudan SA
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Givaudan SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080094930.1A 2019-12-04 2020-12-03 角鲨烯藿烯环化酶(shc)变体 Pending CN115052982A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1917688.2 2019-12-04
GBGB1917688.2A GB201917688D0 (en) 2019-12-04 2019-12-04 SHC enzymes and enzyme variants
PCT/EP2020/084491 WO2021110848A1 (en) 2019-12-04 2020-12-03 Squalene hopene cyclase (shc) variants

Publications (1)

Publication Number Publication Date
CN115052982A true CN115052982A (zh) 2022-09-13

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CN202080094930.1A Pending CN115052982A (zh) 2019-12-04 2020-12-03 角鲨烯藿烯环化酶(shc)变体

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US (2) US12416027B2 (https=)
EP (1) EP4069836A1 (https=)
JP (2) JP7760503B2 (https=)
CN (1) CN115052982A (https=)
BR (1) BR112022009627A2 (https=)
CO (1) CO2022008659A2 (https=)
GB (1) GB201917688D0 (https=)
IL (1) IL293275A (https=)
MX (1) MX2022005939A (https=)
WO (1) WO2021110848A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115851863A (zh) * 2022-11-30 2023-03-28 北京大学深圳研究生院 一种海绵烷骨架化合物的制备方法及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119137269A (zh) 2022-03-17 2024-12-13 奇华顿股份有限公司 Shc酶和酶变体
WO2024112870A1 (en) * 2022-11-23 2024-05-30 Conagen Inc. Conversion of homofarnesol to ambroxide

Citations (4)

* Cited by examiner, † Cited by third party
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CN107567500A (zh) * 2015-04-24 2018-01-09 奇华顿股份有限公司 酶及其应用
CN109071480A (zh) * 2016-04-22 2018-12-21 奇华顿股份有限公司 在生物催化剂存在下通过高法呢醇的生物转化形成的(-)-降龙涎香醚的固体形式
US20190144899A1 (en) * 2016-02-19 2019-05-16 Basf Se Enzymatic cyclization of homofarnesylic acid
CN110312796A (zh) * 2017-02-24 2019-10-08 国际香料和香精公司 角鲨烯何帕烯环化酶及其用于生产降龙涎香醚的用途

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
DE19649655A1 (de) 1996-11-29 1998-06-04 Haarmann & Reimer Gmbh Syntheseenzyme für die Herstellung von Coniferylalkohol, Coniferylaldehyd, Ferulasäure, Vanillin und Vanillinsäure und deren Verwendung
DE19960106A1 (de) 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Enzyme und Gene für die Herstellung von Vanillin
JP5236233B2 (ja) 2007-09-04 2013-07-17 花王株式会社 （−）−アンブロキサンの製造方法
WO2010139719A2 (de) 2009-06-05 2010-12-09 Basf Se Biokatalytische herstellung von ambroxan
EP4112727A3 (de) 2010-11-17 2023-03-15 Basf Se Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
WO2013156398A1 (de) 2012-04-16 2013-10-24 Basf Se Verbessertes verfahren zur herstellung von (3e, 7e)-homofarnesol
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
JP5748381B1 (ja) 2014-07-31 2015-07-15 楽天株式会社 メッセージ処理装置、メッセージ処理方法、記録媒体およびプログラム
GB201507170D0 (en) 2015-04-24 2015-06-10 Givaudan Sa Process
JP2019170350A (ja) 2018-03-30 2019-10-10 国立大学法人千葉大学 スクアレン消費酵素のスクリーニング方法及びスクアレン−ホペン環化酵素
GB201917694D0 (en) * 2019-12-04 2020-01-15 Givaudan Sa Enzyme mediated process

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CN107567500A (zh) * 2015-04-24 2018-01-09 奇华顿股份有限公司 酶及其应用
US20190144899A1 (en) * 2016-02-19 2019-05-16 Basf Se Enzymatic cyclization of homofarnesylic acid
CN109071480A (zh) * 2016-04-22 2018-12-21 奇华顿股份有限公司 在生物催化剂存在下通过高法呢醇的生物转化形成的(-)-降龙涎香醚的固体形式
CN110312796A (zh) * 2017-02-24 2019-10-08 国际香料和香精公司 角鲨烯何帕烯环化酶及其用于生产降龙涎香醚的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TSUTOMU HOSHINO等: "Squalene-hopene cyclase: catalytic mechanism and substrate recognition", CHEM COMMUN (CAMB), no. 04, 21 February 2002 (2002-02-21), pages 291 - 301, XP055533113, DOI: 10.1039/b108995c *
杨绍祥等: "降龙涎醚合成研究进展", 化工学报, no. 01, 28 February 2008 (2008-02-28), pages 23 - 30 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115851863A (zh) * 2022-11-30 2023-03-28 北京大学深圳研究生院 一种海绵烷骨架化合物的制备方法及其应用

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CO2022008659A2 (es) 2022-07-19
JP2023504855A (ja) 2023-02-07
BR112022009627A2 (pt) 2022-08-09
WO2021110848A1 (en) 2021-06-10
US12416027B2 (en) 2025-09-16
JP7760503B2 (ja) 2025-10-27
US20250361536A1 (en) 2025-11-27
IL293275A (en) 2022-07-01
MX2022005939A (es) 2022-09-09
JP2025188332A (ja) 2025-12-26
GB201917688D0 (en) 2020-01-15
US20230021613A1 (en) 2023-01-26
EP4069836A1 (en) 2022-10-12

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