JP7747638B2 - 電界分布の高速近似のための方法、システム、および装置 - Google Patents
電界分布の高速近似のための方法、システム、および装置Info
- Publication number
- JP7747638B2 JP7747638B2 JP2022540520A JP2022540520A JP7747638B2 JP 7747638 B2 JP7747638 B2 JP 7747638B2 JP 2022540520 A JP2022540520 A JP 2022540520A JP 2022540520 A JP2022540520 A JP 2022540520A JP 7747638 B2 JP7747638 B2 JP 7747638B2
- Authority
- JP
- Japan
- Prior art keywords
- electric field
- image data
- patient
- voxels
- predictive model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0522—Magnetic induction tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/20—Analysing
- G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
- G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
- G06F18/2148—Generating training patterns; Bootstrap methods, e.g. bagging or boosting characterised by the process organisation or structure, e.g. boosting cascade
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/20—Analysing
- G06F18/24—Classification techniques
- G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N20/00—Machine learning
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Theoretical Computer Science (AREA)
- Data Mining & Analysis (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Surgery (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Evolutionary Computation (AREA)
- Artificial Intelligence (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Software Systems (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Databases & Information Systems (AREA)
- High Energy & Nuclear Physics (AREA)
- Urology & Nephrology (AREA)
- Mathematical Physics (AREA)
- Computing Systems (AREA)
- Physical Education & Sports Medicine (AREA)
- Quality & Reliability (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Electrotherapy Devices (AREA)
- Computational Linguistics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962955678P | 2019-12-31 | 2019-12-31 | |
| US62/955,678 | 2019-12-31 | ||
| PCT/IB2020/001117 WO2021136971A1 (en) | 2019-12-31 | 2020-12-31 | Methods, systems, and apparatuses for fast approximation of electric field distribution |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023508586A JP2023508586A (ja) | 2023-03-02 |
| JPWO2021136971A5 JPWO2021136971A5 (https=) | 2023-12-27 |
| JP2023508586A5 JP2023508586A5 (https=) | 2023-12-27 |
| JP7747638B2 true JP7747638B2 (ja) | 2025-10-01 |
Family
ID=74661410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540520A Active JP7747638B2 (ja) | 2019-12-31 | 2020-12-31 | 電界分布の高速近似のための方法、システム、および装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US12367961B2 (https=) |
| EP (2) | EP4075442A1 (https=) |
| JP (1) | JP7747638B2 (https=) |
| CN (1) | CN114830248A (https=) |
| WO (1) | WO2021136971A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115803A (zh) * | 2018-02-07 | 2019-08-13 | 张建义 | 一种可用于生物医学研究的电源装置及配套电极阵列设计 |
| EP4099336B1 (en) | 2019-12-02 | 2025-06-18 | Novocure GmbH | Methods and apparatuses for optimizing transducer array placement |
| US11941761B2 (en) | 2019-12-31 | 2024-03-26 | Novocure Gmbh | Methods, systems, and apparatuses for image segmentation |
| JP7747638B2 (ja) | 2019-12-31 | 2025-10-01 | ノボキュア ゲーエムベーハー | 電界分布の高速近似のための方法、システム、および装置 |
| WO2023001546A1 (en) * | 2021-07-19 | 2023-01-26 | Bottneuro Ag | Computer-implemented method for enabling patient-specific electrostimulation of neuronal tissue and associated devices and software |
| EP4282464B1 (en) * | 2022-05-27 | 2024-09-25 | Bottneuro AG | Electrode helmet for electrical recording and/or stimulation |
| EP4122529A1 (en) * | 2021-07-19 | 2023-01-25 | Bottneuro AG | Computer-implemented method for enabling patient-specific electrostimulation of neuronal tissue and associated devices and software |
| US20250006382A1 (en) | 2023-06-28 | 2025-01-02 | Novocure Gmbh | Adapting array layouts to account for tumor progression |
| US20250005750A1 (en) * | 2023-06-30 | 2025-01-02 | Novocure Gmbh | Determining conductivities of medical images based on measured resistances |
| WO2025012879A1 (en) | 2023-07-12 | 2025-01-16 | Novocure Gmbh | Apparatuses, methods, and systems for treating spinal tumors with tumor treating fields |
| WO2025133987A1 (en) | 2023-12-22 | 2025-06-26 | Novocure Gmbh | Determining transducer locations for delivery of tumor treating fields using external measurements of subject and using subject selection tree |
| CN117563139B (zh) * | 2024-01-12 | 2024-04-09 | 湖南安泰康成生物科技有限公司 | 一种利用电场抑制肿瘤增殖的设备及处理器 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018109691A2 (en) | 2016-12-13 | 2018-06-21 | Zeev Bomzon | Treating patients with ttfields with the electrode positions optimized using deformable templates |
| WO2019212804A1 (en) | 2018-04-30 | 2019-11-07 | Elekta, Inc. | Radiotherapy treatment plan modeling using generative adversarial networks |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794566A (fr) | 1972-01-28 | 1973-07-26 | Esb Inc | Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus. |
| DE2907013A1 (de) | 1978-02-24 | 1979-08-30 | American Med Syst | Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich |
| GB2043453A (en) | 1979-02-22 | 1980-10-08 | Electrochem Tech Corp | Improvements in or relating to an electrode |
| FR2627987B3 (fr) | 1988-03-04 | 1990-02-02 | Indiba Sa | Appareil electronique pour la therapie medicale et cosmetique |
| JP5280600B2 (ja) | 2000-02-17 | 2013-09-04 | パルティ、ヨーラム | 分裂中の細胞を破壊するための方法および装置 |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| CA2563817C (en) | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| US7620227B2 (en) * | 2005-12-29 | 2009-11-17 | General Electric Co. | Computer-aided detection system utilizing temporal analysis as a precursor to spatial analysis |
| EP2419171B1 (en) | 2009-04-13 | 2017-11-01 | Research Foundation Of The City University Of New York | Neurocranial electrostimulation models |
| WO2011047387A2 (en) | 2009-10-16 | 2011-04-21 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| EP3119473A1 (en) * | 2014-03-17 | 2017-01-25 | The United States of America, as represented by The Secretary, Department of Health and Human Services | System with an electromagnetic field generator with coils for treating tumors and a method for treating tissue |
| US20190117963A1 (en) | 2014-07-25 | 2019-04-25 | Loyalty Based Innovations, LLC | Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| KR102477057B1 (ko) | 2016-09-20 | 2022-12-14 | 하트플로우, 인크. | 축소 차수 모델 및 기계 학습을 사용한 혈류 특성들의 추정을 위한 시스템 및 방법들 |
| WO2019197999A1 (en) | 2018-04-10 | 2019-10-17 | Zeev Bomzon | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| PL3984590T3 (pl) | 2018-10-15 | 2023-05-02 | Novocure Gmbh | Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu |
| CN112955208B (zh) | 2018-10-25 | 2024-11-22 | 诺沃库勒有限责任公司 | 向受试者的脊柱解剖结构递送交变电场(例如,ttfields)的方法 |
| US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
| EP3968279B1 (en) | 2019-01-08 | 2025-01-01 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| CN109558912A (zh) * | 2019-01-21 | 2019-04-02 | 广西师范大学 | 一种基于深度可分离卷积的阿尔兹海默病分类方法 |
| US11354586B2 (en) | 2019-02-15 | 2022-06-07 | Q Bio, Inc. | Model parameter determination using a predictive model |
| USD934892S1 (en) | 2019-05-03 | 2021-11-02 | Novocure Gmbh | Display screen or portion thereof with a graphical user interface |
| US11620789B2 (en) | 2019-05-03 | 2023-04-04 | Novocure Gmbh | Methods, systems, and apparatuses for managing transducer array placement |
| CN114364433A (zh) | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场(TTFields) |
| EP4099336B1 (en) | 2019-12-02 | 2025-06-18 | Novocure GmbH | Methods and apparatuses for optimizing transducer array placement |
| US11941761B2 (en) | 2019-12-31 | 2024-03-26 | Novocure Gmbh | Methods, systems, and apparatuses for image segmentation |
| JP7747638B2 (ja) | 2019-12-31 | 2025-10-01 | ノボキュア ゲーエムベーハー | 電界分布の高速近似のための方法、システム、および装置 |
| WO2021136964A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Methods, systems, and apparatuses for associating dielectric properties with a patient model |
| US12343529B2 (en) | 2020-03-31 | 2025-07-01 | Novocure Gmbh | Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields |
-
2020
- 2020-12-31 JP JP2022540520A patent/JP7747638B2/ja active Active
- 2020-12-31 US US17/139,475 patent/US12367961B2/en active Active
- 2020-12-31 CN CN202080091138.0A patent/CN114830248A/zh active Pending
- 2020-12-31 EP EP22177342.7A patent/EP4075442A1/en active Pending
- 2020-12-31 WO PCT/IB2020/001117 patent/WO2021136971A1/en not_active Ceased
- 2020-12-31 EP EP20853605.2A patent/EP4052266B1/en active Active
-
2025
- 2025-06-27 US US19/253,205 patent/US20250322931A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018109691A2 (en) | 2016-12-13 | 2018-06-21 | Zeev Bomzon | Treating patients with ttfields with the electrode positions optimized using deformable templates |
| WO2019212804A1 (en) | 2018-04-30 | 2019-11-07 | Elekta, Inc. | Radiotherapy treatment plan modeling using generative adversarial networks |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114830248A (zh) | 2022-07-29 |
| EP4075442A1 (en) | 2022-10-19 |
| US20210196943A1 (en) | 2021-07-01 |
| EP4052266B1 (en) | 2025-07-23 |
| EP4052266A1 (en) | 2022-09-07 |
| US12367961B2 (en) | 2025-07-22 |
| EP4052266C0 (en) | 2025-07-23 |
| JP2023508586A (ja) | 2023-03-02 |
| WO2021136971A1 (en) | 2021-07-08 |
| US20250322931A1 (en) | 2025-10-16 |
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