CN114830248A - 用于电场分布的快速近似的方法、系统和装置 - Google Patents

用于电场分布的快速近似的方法、系统和装置 Download PDF

Info

Publication number
CN114830248A
CN114830248A CN202080091138.0A CN202080091138A CN114830248A CN 114830248 A CN114830248 A CN 114830248A CN 202080091138 A CN202080091138 A CN 202080091138A CN 114830248 A CN114830248 A CN 114830248A
Authority
CN
China
Prior art keywords
electric field
patient
voxels
predictive model
locations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080091138.0A
Other languages
English (en)
Chinese (zh)
Inventor
R·R·沙米尔
Z·邦宗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novokule Co ltd
Original Assignee
Novokule Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novokule Co ltd filed Critical Novokule Co ltd
Publication of CN114830248A publication Critical patent/CN114830248A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/0522—Magnetic induction tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/214—Generating training patterns; Bootstrap methods, e.g. bagging or boosting
    • G06F18/2148—Generating training patterns; Bootstrap methods, e.g. bagging or boosting characterised by the process organisation or structure, e.g. boosting cascade
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Databases & Information Systems (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Urology & Nephrology (AREA)
  • Mathematical Physics (AREA)
  • Computing Systems (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Quality & Reliability (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Electrotherapy Devices (AREA)
  • Computational Linguistics (AREA)
CN202080091138.0A 2019-12-31 2020-12-31 用于电场分布的快速近似的方法、系统和装置 Pending CN114830248A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962955678P 2019-12-31 2019-12-31
US62/955678 2019-12-31
PCT/IB2020/001117 WO2021136971A1 (en) 2019-12-31 2020-12-31 Methods, systems, and apparatuses for fast approximation of electric field distribution

Publications (1)

Publication Number Publication Date
CN114830248A true CN114830248A (zh) 2022-07-29

Family

ID=74661410

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080091138.0A Pending CN114830248A (zh) 2019-12-31 2020-12-31 用于电场分布的快速近似的方法、系统和装置

Country Status (5)

Country Link
US (2) US12367961B2 (https=)
EP (2) EP4075442A1 (https=)
JP (1) JP7747638B2 (https=)
CN (1) CN114830248A (https=)
WO (1) WO2021136971A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110115803A (zh) * 2018-02-07 2019-08-13 张建义 一种可用于生物医学研究的电源装置及配套电极阵列设计
EP4099336B1 (en) 2019-12-02 2025-06-18 Novocure GmbH Methods and apparatuses for optimizing transducer array placement
US11941761B2 (en) 2019-12-31 2024-03-26 Novocure Gmbh Methods, systems, and apparatuses for image segmentation
JP7747638B2 (ja) 2019-12-31 2025-10-01 ノボキュア ゲーエムベーハー 電界分布の高速近似のための方法、システム、および装置
WO2023001546A1 (en) * 2021-07-19 2023-01-26 Bottneuro Ag Computer-implemented method for enabling patient-specific electrostimulation of neuronal tissue and associated devices and software
EP4282464B1 (en) * 2022-05-27 2024-09-25 Bottneuro AG Electrode helmet for electrical recording and/or stimulation
EP4122529A1 (en) * 2021-07-19 2023-01-25 Bottneuro AG Computer-implemented method for enabling patient-specific electrostimulation of neuronal tissue and associated devices and software
US20250006382A1 (en) 2023-06-28 2025-01-02 Novocure Gmbh Adapting array layouts to account for tumor progression
US20250005750A1 (en) * 2023-06-30 2025-01-02 Novocure Gmbh Determining conductivities of medical images based on measured resistances
WO2025012879A1 (en) 2023-07-12 2025-01-16 Novocure Gmbh Apparatuses, methods, and systems for treating spinal tumors with tumor treating fields
WO2025133987A1 (en) 2023-12-22 2025-06-26 Novocure Gmbh Determining transducer locations for delivery of tumor treating fields using external measurements of subject and using subject selection tree
CN117563139B (zh) * 2024-01-12 2024-04-09 湖南安泰康成生物科技有限公司 一种利用电场抑制肿瘤增殖的设备及处理器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070165920A1 (en) * 2005-12-29 2007-07-19 Gering David T Computer-aided detection system utilizing temporal analysis as a precursor to spatial analysis
US20170014637A1 (en) * 2014-03-17 2017-01-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv System with an electromagentic field generator with coils for treating tumors and a method for treating tissue
CN110234394A (zh) * 2016-12-13 2019-09-13 兹夫·波姆森 使用具有用可变形模板优化过的电极位置的TTField治疗患者
US20190333623A1 (en) * 2018-04-30 2019-10-31 Elekta, Inc. Radiotherapy treatment plan modeling using generative adversarial networks

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794566A (fr) 1972-01-28 1973-07-26 Esb Inc Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus.
DE2907013A1 (de) 1978-02-24 1979-08-30 American Med Syst Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich
GB2043453A (en) 1979-02-22 1980-10-08 Electrochem Tech Corp Improvements in or relating to an electrode
FR2627987B3 (fr) 1988-03-04 1990-02-02 Indiba Sa Appareil electronique pour la therapie medicale et cosmetique
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
EP2419171B1 (en) 2009-04-13 2017-11-01 Research Foundation Of The City University Of New York Neurocranial electrostimulation models
WO2011047387A2 (en) 2009-10-16 2011-04-21 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US20190117963A1 (en) 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
KR102477057B1 (ko) 2016-09-20 2022-12-14 하트플로우, 인크. 축소 차수 모델 및 기계 학습을 사용한 혈류 특성들의 추정을 위한 시스템 및 방법들
WO2019197999A1 (en) 2018-04-10 2019-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
PL3984590T3 (pl) 2018-10-15 2023-05-02 Novocure Gmbh Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu
CN112955208B (zh) 2018-10-25 2024-11-22 诺沃库勒有限责任公司 向受试者的脊柱解剖结构递送交变电场(例如，ttfields)的方法
US20200146586A1 (en) 2018-11-14 2020-05-14 Novocure Gmbh Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images
EP3968279B1 (en) 2019-01-08 2025-01-01 Novocure GmbH Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
CN109558912A (zh) * 2019-01-21 2019-04-02 广西师范大学 一种基于深度可分离卷积的阿尔兹海默病分类方法
US11354586B2 (en) 2019-02-15 2022-06-07 Q Bio, Inc. Model parameter determination using a predictive model
USD934892S1 (en) 2019-05-03 2021-11-02 Novocure Gmbh Display screen or portion thereof with a graphical user interface
US11620789B2 (en) 2019-05-03 2023-04-04 Novocure Gmbh Methods, systems, and apparatuses for managing transducer array placement
CN114364433A (zh) 2019-08-30 2022-04-15 诺沃库勒有限责任公司 向颈部输送肿瘤治疗场（TTFields）
EP4099336B1 (en) 2019-12-02 2025-06-18 Novocure GmbH Methods and apparatuses for optimizing transducer array placement
US11941761B2 (en) 2019-12-31 2024-03-26 Novocure Gmbh Methods, systems, and apparatuses for image segmentation
JP7747638B2 (ja) 2019-12-31 2025-10-01 ノボキュア ゲーエムベーハー 電界分布の高速近似のための方法、システム、および装置
WO2021136964A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh Methods, systems, and apparatuses for associating dielectric properties with a patient model
US12343529B2 (en) 2020-03-31 2025-07-01 Novocure Gmbh Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070165920A1 (en) * 2005-12-29 2007-07-19 Gering David T Computer-aided detection system utilizing temporal analysis as a precursor to spatial analysis
US20170014637A1 (en) * 2014-03-17 2017-01-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv System with an electromagentic field generator with coils for treating tumors and a method for treating tissue
CN110234394A (zh) * 2016-12-13 2019-09-13 兹夫·波姆森 使用具有用可变形模板优化过的电极位置的TTField治疗患者
US20190333623A1 (en) * 2018-04-30 2019-10-31 Elekta, Inc. Radiotherapy treatment plan modeling using generative adversarial networks

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHAMTR R R , ET AL: "a method for tumor treating fields fast estimation", ARXIV.ORG, CORNELL UNIVERSITY LIBARARY, 201OLIN LIBRARY CORNELL UNIVERSITY ITHACA NY14853, 6 October 2020 (2020-10-06), pages 5 - 6 *

Also Published As

Publication number Publication date
JP7747638B2 (ja) 2025-10-01
EP4075442A1 (en) 2022-10-19
US20210196943A1 (en) 2021-07-01
EP4052266B1 (en) 2025-07-23
EP4052266A1 (en) 2022-09-07
US12367961B2 (en) 2025-07-22
EP4052266C0 (en) 2025-07-23
JP2023508586A (ja) 2023-03-02
WO2021136971A1 (en) 2021-07-08
US20250322931A1 (en) 2025-10-16

Similar Documents

Publication Publication Date Title
JP7747638B2 (ja) 電界分布の高速近似のための方法、システム、および装置
US20260047807A1 (en) Methods, systems, and apparatuses for associating dielectric properties with a patient model
US12115381B2 (en) Methods, systems, and apparatuses for optimizing transducer array placement
US12131428B2 (en) Methods, systems, and apparatuses for image segmentation
CN114845767A (zh) 用于管理由交变场感应的温度的方法、系统和装置
WO2021136960A1 (en) Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy
CN113939332A (zh) 用于管理换能器阵列放置的方法、系统和装置
HK40073659A (en) Methods, systems, and apparatuses for fast approximation of electric field distribution
HK40077688A (en) Methods, systems, and apparatuses for image segmentation
HK40076919A (en) Methods, systems, and apparatuses for image segmentation
HK40071311B (en) Methods, systems, and apparatuses for image segmentation
HK40071311A (en) Methods, systems, and apparatuses for image segmentation

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination