JP7747337B2 - 速度論的光学分割のためのカルボキシエステラーゼポリペプチド - Google Patents

速度論的光学分割のためのカルボキシエステラーゼポリペプチド

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Publication number
JP7747337B2
JP7747337B2 JP2022561488A JP2022561488A JP7747337B2 JP 7747337 B2 JP7747337 B2 JP 7747337B2 JP 2022561488 A JP2022561488 A JP 2022561488A JP 2022561488 A JP2022561488 A JP 2022561488A JP 7747337 B2 JP7747337 B2 JP 7747337B2
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carboxylesterase
engineered
sequence
polypeptide
seq
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JP2023521972A (ja
JP2023521972A5 (https=
Inventor
ラマ ボラドリ，
ジェシカ アンナ フルタク，
オーリック アンソニー ソーウェル－カンツ，
ナンディタ スブラマニアン，
エリカ バームデス，
デイビッド エントウィッスル，
メリッサ アン メイヨー，
ジェイムズ ニコラス リギンズ，
スコット ジェイ． ノヴィック，
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コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • External Artificial Organs (AREA)
JP2022561488A 2020-04-10 2021-04-06 速度論的光学分割のためのカルボキシエステラーゼポリペプチド Active JP7747337B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063008061P 2020-04-10 2020-04-10
US63/008,061 2020-04-10
PCT/US2021/025975 WO2021207208A1 (en) 2020-04-10 2021-04-06 Carboxyesterase polypeptides for kinetic resolution

Publications (3)

Publication Number Publication Date
JP2023521972A JP2023521972A (ja) 2023-05-26
JP2023521972A5 JP2023521972A5 (https=) 2024-04-10
JP7747337B2 true JP7747337B2 (ja) 2025-10-01

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JP2022561488A Active JP7747337B2 (ja) 2020-04-10 2021-04-06 速度論的光学分割のためのカルボキシエステラーゼポリペプチド

Country Status (7)

Country Link
US (1) US12612605B2 (https=)
EP (1) EP4133065A4 (https=)
JP (1) JP7747337B2 (https=)
CN (1) CN115397978A (https=)
CA (1) CA3179679A1 (https=)
IL (1) IL296983A (https=)
WO (1) WO2021207208A1 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
BR112021020368A2 (pt) * 2019-04-11 2021-12-07 Bristol Myers Squibb Co Opções sintéticas para a fabricação de (6r,10s)-10-{4-[5-cloro-2-(4-cloro-1h-1,2,3-triazol-1-il)fenil]-6-oxo-1(6h)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexa-hidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6h)-ona
CN115896065B (zh) * 2022-09-06 2023-08-11 江南大学 一种立体选择性羧酯酶、编码基因、载体及其应用

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WO2019118557A1 (en) 2017-12-13 2019-06-20 Codexis, Inc. Carboxyesterase polypeptides for amide coupling

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Also Published As

Publication number Publication date
EP4133065A1 (en) 2023-02-15
JP2023521972A (ja) 2023-05-26
US20230159904A1 (en) 2023-05-25
CA3179679A1 (en) 2021-10-14
WO2021207208A1 (en) 2021-10-14
CN115397978A (zh) 2022-11-25
IL296983A (en) 2022-12-01
EP4133065A4 (en) 2024-07-10
US12612605B2 (en) 2026-04-28

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