JP7738911B2 - ガン治療薬及びガン治療方法 - Google Patents

ガン治療薬及びガン治療方法

Info

Publication number
JP7738911B2
JP7738911B2 JP2022518156A JP2022518156A JP7738911B2 JP 7738911 B2 JP7738911 B2 JP 7738911B2 JP 2022518156 A JP2022518156 A JP 2022518156A JP 2022518156 A JP2022518156 A JP 2022518156A JP 7738911 B2 JP7738911 B2 JP 7738911B2
Authority
JP
Japan
Prior art keywords
salt
cancer
drug
cationic
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022518156A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021221167A1 (https=
Inventor
均 佐々木
友亮 ▲黒▼▲崎▼
幸修 兒玉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nagasaki University NUC
Original Assignee
Nagasaki University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagasaki University NUC filed Critical Nagasaki University NUC
Publication of JPWO2021221167A1 publication Critical patent/JPWO2021221167A1/ja
Application granted granted Critical
Publication of JP7738911B2 publication Critical patent/JP7738911B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022518156A 2020-04-30 2021-04-30 ガン治療薬及びガン治療方法 Active JP7738911B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020080455 2020-04-30
JP2020080455 2020-04-30
PCT/JP2021/017240 WO2021221167A1 (ja) 2020-04-30 2021-04-30 ガン治療薬及びガン治療方法

Publications (2)

Publication Number Publication Date
JPWO2021221167A1 JPWO2021221167A1 (https=) 2021-11-04
JP7738911B2 true JP7738911B2 (ja) 2025-09-16

Family

ID=78332045

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022518156A Active JP7738911B2 (ja) 2020-04-30 2021-04-30 ガン治療薬及びガン治療方法

Country Status (2)

Country Link
JP (1) JP7738911B2 (https=)
WO (1) WO2021221167A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025030598A (ja) * 2023-08-24 2025-03-07 国立大学法人京都工芸繊維大学 イオン性化学種濃縮方法および脂質粒子

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010059064A (ja) 2008-09-01 2010-03-18 Nagasaki Univ 薬物送達複合体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL366025A1 (pl) * 2000-05-03 2005-01-24 Munich Biotech Ag Kationowe środki diagnostyczne, obrazujące i terapeutyczne, zasocjowane z uaktywnionymi miejscami wnaczyniach
EP1553924B1 (en) * 2002-06-26 2010-12-08 MediGene AG Novel method of stabilizing diagnostic and therapeutic compounds in a cationic carrier system
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
WO2019157145A1 (en) * 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Gamma polyglutamated pemetrexed and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010059064A (ja) 2008-09-01 2010-03-18 Nagasaki Univ 薬物送達複合体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Kumiko Sakai-Kato et al.，Effects of lipid composition on the properties of doxorubicin-loaded liposomes，Therapeutic Delivery ，2015年，Vol.6, No.7，Pages 785-794
Marcus Schmitt-Sody et al.，Neovascular Targeting Therapy: Paclitaxel Encapsulated in Cationic Liposomes Improves Antitumoral Efficacy，Clinical Cancer Research，2003年，Vol.9, No.6，Pages 2335-2341
Na Qi et al.，Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors，Nanoscale Research Letters，2017年，Vol.12，Article Number:361, Pages 1-13

Also Published As

Publication number Publication date
WO2021221167A1 (ja) 2021-11-04
JPWO2021221167A1 (https=) 2021-11-04

Similar Documents

Publication Publication Date Title
AU2023263442B2 (en) Polyglutamated Antifolates And Uses Thereof
US11534498B2 (en) Polyglutamated antifolates and uses thereof
CN102114000B (zh) 一种载药的共输送脂质纳米递药系统
US20030166602A1 (en) Targeted drug delivery with a CD44 receptor ligand
BR112017002767B1 (pt) Composição de antifolato lipossomal, seu uso, método de preparação da mesma e kit
JP2006248978A (ja) 新規なリポソーム製剤
WO2018031980A1 (en) Polyglutamated antifolates and uses thereof
US9457082B2 (en) Liposome including complex of hydrophobic active ingredient and polypeptide and use of the liposome
AU2003216445A1 (en) Therapeutic methods for acute myeloid leukemia
JP7738911B2 (ja) ガン治療薬及びガン治療方法
JP2010505880A (ja) ｐＨ感受性リポソーム組成物
CN103393597B (zh) 疏水性肽修饰的注射用长循环脂质体给药系统
US10925831B2 (en) Liposomal formulations of platinum-acridine anticancer agents and methods thereof
JP2011211996A (ja) 腫瘍特異性を有するリポソーム
CN102458365A (zh) 一种用于脑内递送的连接有抗坏血酸的纳米系统
BR112019002495B1 (pt) Composição lipossomal peguilada de antifolatos poliglutamatados, seu uso e método de preparação
BR122024017509A2 (pt) Composições lipossomais de antifolatos poliglutamatados d- glutamil, seu uso e método de preparação
BR122024017509B1 (pt) Composições lipossomais de antifolatos poliglutamatados dglutamil, seu uso e método de preparação
BR112019002497B1 (pt) Composições lipossomais de antifolatos poliglutamatados alfa, seu uso e método de preparação
OA19187A (en) Polyglutamated antifolates and uses thereof.
OA19185A (en) Alpha and Gamma-D polyglutamated antifolates and uses thereof.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220706

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240313

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250519

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250711

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250825

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250827

R150 Certificate of patent or registration of utility model

Ref document number: 7738911

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150