JP7734487B2 - 新規抗トロポニンｔ抗体 - Google Patents

新規抗トロポニンｔ抗体

Info

Publication number
JP7734487B2
JP7734487B2 JP2020547412A JP2020547412A JP7734487B2 JP 7734487 B2 JP7734487 B2 JP 7734487B2 JP 2020547412 A JP2020547412 A JP 2020547412A JP 2020547412 A JP2020547412 A JP 2020547412A JP 7734487 B2 JP7734487 B2 JP 7734487B2
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
antibody
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020547412A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021515567A (ja
Inventor
クロナー，フランク
シュレームル，ミヒャエル
リートケ，サラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2021515567A publication Critical patent/JP2021515567A/ja
Priority to JP2023104991A priority Critical patent/JP2023126845A/ja
Priority to JP2025092477A priority patent/JP2025166830A/ja
Application granted granted Critical
Publication of JP7734487B2 publication Critical patent/JP7734487B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
JP2020547412A 2018-03-14 2019-03-12 新規抗トロポニンｔ抗体 Active JP7734487B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023104991A JP2023126845A (ja) 2018-03-14 2023-06-27 新規抗トロポニンｔ抗体
JP2025092477A JP2025166830A (ja) 2018-03-14 2025-06-03 新規抗トロポニンｔ抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18161697 2018-03-14
EP18161697.0 2018-03-14
PCT/EP2019/056069 WO2019175127A1 (en) 2018-03-14 2019-03-12 Novel anti-troponint antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023104991A Division JP2023126845A (ja) 2018-03-14 2023-06-27 新規抗トロポニンｔ抗体

Publications (2)

Publication Number Publication Date
JP2021515567A JP2021515567A (ja) 2021-06-24
JP7734487B2 true JP7734487B2 (ja) 2025-09-05

Family

ID=61655635

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020547412A Active JP7734487B2 (ja) 2018-03-14 2019-03-12 新規抗トロポニンｔ抗体
JP2023104991A Pending JP2023126845A (ja) 2018-03-14 2023-06-27 新規抗トロポニンｔ抗体
JP2025092477A Pending JP2025166830A (ja) 2018-03-14 2025-06-03 新規抗トロポニンｔ抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023104991A Pending JP2023126845A (ja) 2018-03-14 2023-06-27 新規抗トロポニンｔ抗体
JP2025092477A Pending JP2025166830A (ja) 2018-03-14 2025-06-03 新規抗トロポニンｔ抗体

Country Status (7)

Country Link
US (1) US12275778B2 (enExample)
EP (1) EP3765497A1 (enExample)
JP (3) JP7734487B2 (enExample)
KR (1) KR20200133229A (enExample)
CN (1) CN111971300B (enExample)
BR (1) BR112020017941A2 (enExample)
WO (1) WO2019175127A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114206920B (zh) * 2019-08-09 2024-06-07 豪夫迈·罗氏有限公司 新型抗肌钙蛋白t抗体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010527920A (ja) 2007-05-08 2010-08-19 アボット・ラボラトリーズ ヒトｂｎｐ免疫特異的抗体
JP2012518418A (ja) 2009-02-24 2012-08-16 アボット・ラボラトリーズ トロポニンｉに対する抗体およびこれらの使用法
JP2013513108A (ja) 2009-12-03 2013-04-18 アボット・ラボラトリーズ 心筋細胞損傷の診断のためのアッセイ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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US5342606A (en) 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US5316757A (en) 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE3922873A1 (de) * 1989-04-25 1990-10-31 Boehringer Mannheim Gmbh Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen
US6333397B1 (en) 1989-04-25 2001-12-25 Roche Diagnostics Gmbh Monoclonal antibodies to troponin T and their production
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5739294A (en) 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5428139A (en) 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
US5385893A (en) 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5462725A (en) 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5403482A (en) 1993-10-12 1995-04-04 Gelman Sciences Inc. Self-supporting, pleated, spirally wound filter and the corresponding process of making
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US5834456A (en) 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
AU2012215497B2 (en) 2011-02-09 2016-07-28 F. Hoffmann-La Roche Ag New iridium-based complexes for ECL
CN102565422B (zh) * 2011-12-29 2014-05-07 深圳康美生物科技股份有限公司 一种定量检测心肌肌钙蛋白t的荧光免疫层析方法及其试剂盒
CN106124771A (zh) * 2016-06-13 2016-11-16 南京普朗医疗设备有限公司 一种一步均相cTnT检测试剂盒及其应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010527920A (ja) 2007-05-08 2010-08-19 アボット・ラボラトリーズ ヒトｂｎｐ免疫特異的抗体
JP2012518418A (ja) 2009-02-24 2012-08-16 アボット・ラボラトリーズ トロポニンｉに対する抗体およびこれらの使用法
JP2013513108A (ja) 2009-12-03 2013-04-18 アボット・ラボラトリーズ 心筋細胞損傷の診断のためのアッセイ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Affinity Maturation of Monoclonal Antibodies by Multi-Site-Directed Mutagenesis, Monoclonal Antibodies: Methods and Protocols, Methods in Molecular Biology, 2014年, Vol. 1131, pp. 407-420
Latest technologies for the enhancement of antibody affinity, Advanced Drug Delivery Reivews, 2006年, Vol. 58, pp. 657-670

Also Published As

Publication number Publication date
CN111971300B (zh) 2024-10-29
US12275778B2 (en) 2025-04-15
BR112020017941A2 (pt) 2021-02-17
KR20200133229A (ko) 2020-11-26
EP3765497A1 (en) 2021-01-20
JP2025166830A (ja) 2025-11-06
JP2023126845A (ja) 2023-09-12
CN111971300A (zh) 2020-11-20
US20210009668A1 (en) 2021-01-14
JP2021515567A (ja) 2021-06-24
WO2019175127A1 (en) 2019-09-19

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