JP7702654B2 - トリプタミンプロドラッグ - Google Patents

トリプタミンプロドラッグ Download PDF

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Publication number
JP7702654B2
JP7702654B2 JP2022580938A JP2022580938A JP7702654B2 JP 7702654 B2 JP7702654 B2 JP 7702654B2 JP 2022580938 A JP2022580938 A JP 2022580938A JP 2022580938 A JP2022580938 A JP 2022580938A JP 7702654 B2 JP7702654 B2 JP 7702654B2
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alkyl
compounds
compound
depression
drug
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Japanese (ja)
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JP2023531311A (ja
JP2023531311A5 (https=
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ブライソン、ネイサン
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Reunion Neuroscience Inc
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Reunion Neuroscience Inc
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Priority to JP2025094025A priority Critical patent/JP2025143280A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022580938A 2020-06-30 2021-06-30 トリプタミンプロドラッグ Active JP7702654B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025094025A JP2025143280A (ja) 2020-06-30 2025-06-05 トリプタミンプロドラッグ

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063045901P 2020-06-30 2020-06-30
US63/045,901 2020-06-30
US202063109095P 2020-11-03 2020-11-03
US63/109,095 2020-11-03
US17/364,047 US11292765B2 (en) 2020-06-30 2021-06-30 Tryptamine prodrugs
PCT/CA2021/050907 WO2022000091A1 (en) 2020-06-30 2021-06-30 Tryptamine prodrugs
US17/364,047 2021-06-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025094025A Division JP2025143280A (ja) 2020-06-30 2025-06-05 トリプタミンプロドラッグ

Publications (3)

Publication Number Publication Date
JP2023531311A JP2023531311A (ja) 2023-07-21
JP2023531311A5 JP2023531311A5 (https=) 2024-07-09
JP7702654B2 true JP7702654B2 (ja) 2025-07-04

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JP2022580938A Active JP7702654B2 (ja) 2020-06-30 2021-06-30 トリプタミンプロドラッグ
JP2025094025A Pending JP2025143280A (ja) 2020-06-30 2025-06-05 トリプタミンプロドラッグ

Family Applications After (1)

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JP2025094025A Pending JP2025143280A (ja) 2020-06-30 2025-06-05 トリプタミンプロドラッグ

Country Status (10)

Country Link
US (4) US11292765B2 (https=)
EP (1) EP4172145A4 (https=)
JP (2) JP7702654B2 (https=)
KR (2) KR102829078B1 (https=)
CN (3) CN119285527A (https=)
AU (1) AU2021302692A1 (https=)
CA (1) CA3181092A1 (https=)
IL (2) IL299506B2 (https=)
MX (1) MX2022016212A (https=)
WO (1) WO2022000091A1 (https=)

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CA3152752A1 (en) 2019-10-01 2021-04-08 Thomas Henley Genetic engineering of fungi to modulate tryptamine expression
KR20220137081A (ko) 2020-02-04 2022-10-11 마인드셋 파마 인크. Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 실로신 유도체
BR112022015379A2 (pt) 2020-02-04 2022-09-27 Mindset Pharma Inc Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc
WO2021226416A1 (en) 2020-05-08 2021-11-11 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
CN119285527A (zh) * 2020-06-30 2025-01-10 瑞安神经科学公司 色胺前药
WO2022040802A1 (en) * 2020-08-26 2022-03-03 Magicmed Industries Inc. Glycosylated psilocybin derivatives and methods of using
EP4255422A4 (en) * 2020-12-03 2024-12-18 Mydecine Innovations Group Inc. NEW PSILOCIN ANALOGUE COMPOSITIONS AND METHODS OF THEIR SYNTHESIS
JP2024500397A (ja) * 2020-12-18 2024-01-09 コンパス パスファインダー リミテッド 治療用途のための修飾インドールアルカロイド
EP4155306A1 (en) 2021-01-15 2023-03-29 Beckley Psytech Limited Neuroactive ergoline analogue
US12534441B2 (en) 2021-01-15 2026-01-27 Beckley Psytech Limited Tryptamine analogues
US11312684B1 (en) 2021-02-10 2022-04-26 Eleusis Therapeutics Us, Inc. Pharmaceutically acceptable salts of psilocin and uses thereof
MX2023014630A (es) 2021-06-08 2024-01-30 Atai Therapeutics Inc Activadores de dimetoxifenilalquilamina de receptores de serotonina.
AU2022309017A1 (en) 2021-07-07 2024-01-25 Terran Biosciences Inc. N,n-dimethyltryptamine and related psychedlics and uses thereof
KR20240058859A (ko) 2021-08-12 2024-05-03 쿨레온 엘엘씨 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법
JP2024534801A (ja) * 2021-08-20 2024-09-26 テラン バイオサイエンシズ インコーポレイテッド サイロシンのプロドラッグ及び誘導体ならびにその使用
US20250011351A1 (en) 2021-11-12 2025-01-09 Terran Biosciences Inc. Psilocybin and o-acetylpsilocin, salts and solid state forms thereof
EP4444698A4 (en) * 2021-12-10 2025-07-09 Caamtech Inc PSILOCYBIN DERIVATIVES
US20250051278A1 (en) * 2021-12-14 2025-02-13 Reunion Neuroscience, Inc. Tryptamine prodrugs
EP4457203A4 (en) 2021-12-27 2025-12-17 Atai Therapeutics Inc AMINOTETRALINE ACTIVATORS OF SEROTONIN RECEPTORS
WO2023129956A2 (en) 2021-12-30 2023-07-06 ATAI Life Sciences AG Dimethyltryptamine analogues as nitric oxide delivery drugs
CN118984868A (zh) 2021-12-31 2024-11-19 恩派瑞安神经科学公司 用于产生精神药物生物碱的遗传修饰的生物体
WO2023133477A1 (en) * 2022-01-06 2023-07-13 Terran Biosciences, Inc. Salts and solid forms of 4-hydroxy-n,n-diisopropyltryptamine hemi-glutarate and hemi-succinate
WO2023147423A1 (en) * 2022-01-28 2023-08-03 Miralogx Llc Anxiolytic compounds, pharmaceutical compositions, and methods of treating anxiety and other disorders
WO2023168023A1 (en) 2022-03-04 2023-09-07 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
US20250186369A1 (en) * 2022-03-07 2025-06-12 Drexel University Compounds, compositions, and methods for treating, ameliorating, and/or prventing cocaine use disorder
AU2023234202A1 (en) * 2022-03-18 2024-11-07 Enveric Biosciences Canada Inc. Salts of c4-carboxylic acid- and c4-carbonothioate-substituted tryptamine derivatives and methods of using
CA3246245A1 (en) * 2022-03-18 2023-09-21 Enveric Biosciences Canada Inc. C4 CARBOXYLIC ACID SUBSTITUTED TRYPTAMINE DERIVATIVES AND METHODS OF USE
WO2023173196A1 (en) 2022-03-18 2023-09-21 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
EP4493542A4 (en) * 2022-03-18 2026-03-04 Enveric Biosciences Canada Inc C4-CARBONOTHIOATE SUBSTITUTED TRYPTAMINE DERIVATIVES AND METHODS OF USE
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CN115521240B (zh) * 2022-06-01 2024-05-28 杭州奥泰生物技术股份有限公司 一种二甲基色胺半抗原和人工抗原及其制备方法与应用
CA3258595A1 (en) * 2022-07-27 2024-02-01 Reconnect Labs Ag HIGHLY SOLUBBLE FORMULATIONS BASED ON HARMIN
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
CN116283885B (zh) * 2022-12-01 2025-02-14 杭州奥泰生物技术股份有限公司 一种帕罗西汀半抗原和人工抗原及其制备方法与应用
WO2024145719A1 (en) * 2023-01-05 2024-07-11 Reunion Neuroscience Inc. Improved pharmacokinetics of tryptamine prodrugs
WO2024178051A2 (en) * 2023-02-22 2024-08-29 Caamtech, Inc. Tryptamine derivatives
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US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
WO2025099725A1 (en) * 2023-11-09 2025-05-15 Hadasit Medical Research Services And Development Ltd. Conjugates and uses thereof
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JP2024500397A (ja) * 2020-12-18 2024-01-09 コンパス パスファインダー リミテッド 治療用途のための修飾インドールアルカロイド

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Publication number Publication date
IL299506B2 (en) 2025-10-01
CN119285526A (zh) 2025-01-10
IL299506A (en) 2023-02-01
IL299506B1 (en) 2025-06-01
CA3181092A1 (en) 2022-01-06
US20250382267A1 (en) 2025-12-18
KR20250103811A (ko) 2025-07-07
US20250129023A1 (en) 2025-04-24
EP4172145A4 (en) 2024-08-21
AU2021302692A1 (en) 2023-01-19
WO2022000091A1 (en) 2022-01-06
US20210403425A1 (en) 2021-12-30
EP4172145A1 (en) 2023-05-03
JP2025143280A (ja) 2025-10-01
US20220177427A1 (en) 2022-06-09
CN115867533B (zh) 2024-07-23
US11292765B2 (en) 2022-04-05
KR20230028543A (ko) 2023-02-28
IL320601A (en) 2025-07-01
CN119285527A (zh) 2025-01-10
KR102829078B1 (ko) 2025-07-04
MX2022016212A (es) 2023-03-02
JP2023531311A (ja) 2023-07-21
CN115867533A (zh) 2023-03-28

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