JP7695228B2 - ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体 - Google Patents

ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体 Download PDF

Info

Publication number
JP7695228B2
JP7695228B2 JP2022502245A JP2022502245A JP7695228B2 JP 7695228 B2 JP7695228 B2 JP 7695228B2 JP 2022502245 A JP2022502245 A JP 2022502245A JP 2022502245 A JP2022502245 A JP 2022502245A JP 7695228 B2 JP7695228 B2 JP 7695228B2
Authority
JP
Japan
Prior art keywords
seq
canine
amino acid
antibody
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022502245A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022541767A (ja
Inventor
モージー，モハマド
チャン，ユアンチョン
ターピー，イアン
Original Assignee
インターベット インターナショナル ベー． フェー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インターベット インターナショナル ベー． フェー． filed Critical インターベット インターナショナル ベー． フェー．
Publication of JP2022541767A publication Critical patent/JP2022541767A/ja
Priority to JP2025025886A priority Critical patent/JP2025081549A/ja
Application granted granted Critical
Publication of JP7695228B2 publication Critical patent/JP7695228B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022502245A 2019-07-15 2020-07-15 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体 Active JP7695228B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025025886A JP2025081549A (ja) 2019-07-15 2025-02-20 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962874287P 2019-07-15 2019-07-15
US62/874,287 2019-07-15
PCT/EP2020/069924 WO2021009188A1 (en) 2019-07-15 2020-07-15 Caninized antibodies to human and canine ctla-4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025025886A Division JP2025081549A (ja) 2019-07-15 2025-02-20 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体

Publications (2)

Publication Number Publication Date
JP2022541767A JP2022541767A (ja) 2022-09-27
JP7695228B2 true JP7695228B2 (ja) 2025-06-18

Family

ID=71620455

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022502245A Active JP7695228B2 (ja) 2019-07-15 2020-07-15 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体
JP2025025886A Pending JP2025081549A (ja) 2019-07-15 2025-02-20 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025025886A Pending JP2025081549A (ja) 2019-07-15 2025-02-20 ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体

Country Status (8)

Country Link
US (1) US20220251209A1 (enExample)
EP (1) EP3999539A1 (enExample)
JP (2) JP7695228B2 (enExample)
CN (2) CN114174336B (enExample)
AU (1) AU2020312687A1 (enExample)
BR (1) BR112022000604A2 (enExample)
CA (1) CA3145347A1 (enExample)
WO (1) WO2021009188A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022000604A2 (pt) * 2019-07-15 2022-03-03 Intervet Int Bv Anticorpos caninizados para ctla-4 humana
WO2024145278A2 (en) 2022-12-27 2024-07-04 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
WO2024155982A2 (en) 2023-01-20 2024-07-25 Invetx, Inc. Bispecific binding agents for use in companion animals
CN117343185B (zh) * 2023-12-06 2024-03-01 北京伟杰信生物科技有限公司 一种抗犬pd-1抗体及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014512809A (ja) 2011-03-09 2014-05-29 アンチトープ・リミテッド ヒト化抗ｃｔｌａ４抗体
JP2017500867A (ja) 2013-12-20 2017-01-12 インターベット インターナショナル ベー． フェー． ヒトｐｄ−１に対するイヌ化マウス抗体
WO2017062615A2 (en) 2015-10-08 2017-04-13 Macrogenics, Inc. Combination therapy for the treatment of cancer
JP2017534267A (ja) 2014-09-30 2017-11-24 インターベット インターナショナル ベー． フェー． イヌｐｄ−ｌ１と結合するｐｄ−ｌ１抗体
JP2019506146A (ja) 2015-12-18 2019-03-07 インターベット インターナショナル ベー． フェー． ヒトおよびイヌｉｌ−４ｒアルファに対するイヌ化ヒト抗体

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
DE3668186D1 (de) 1985-04-01 1990-02-15 Celltech Ltd Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
CA2356215C (en) 1998-12-23 2015-11-24 Pfizer Inc. Human monoclonal antibodies to ctla-4
ES2568899T3 (es) 1999-04-09 2016-05-05 Kyowa Hakko Kirin Co., Ltd. Procedimiento para controlar la actividad de una molécula inmunofuncional
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
AU2001253282A1 (en) * 2000-04-07 2001-10-23 Heska Corporation Compositions and methods related to canine igg and canine il-13 receptors
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2003060080A2 (en) * 2001-12-21 2003-07-24 Idexx Laboratories, Inc. Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
GB0903325D0 (en) 2009-02-26 2009-04-08 Univ Aberdeen Antibody molecules
CA2754408A1 (en) * 2009-03-30 2010-10-14 Boehringer Ingelheim International Gmbh Fusion proteins comprising canine fc portions
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
HK1201281A1 (en) * 2011-10-13 2015-08-28 Nexvet Australia Pty Ltd Canine/feline cd20 binding epitope and compositions for binding thereto
JP6629069B2 (ja) * 2012-06-06 2020-01-15 ゾエティス・エルエルシー イヌ化抗ｎｇｆ抗体およびその方法
CN113861294B (zh) * 2015-04-02 2024-03-08 英特维特国际股份有限公司 针对犬白介素-4受体α的抗体
AU2017315146A1 (en) * 2016-08-26 2019-04-11 Sanofi Multispecific antibodies facilitating selective light chain pairing
BR112021004723A2 (pt) * 2018-09-14 2021-06-08 Kindred Biosciences, Inc. anticorpos de receptor anti-il4 para uso veterinário
BR112022000604A2 (pt) * 2019-07-15 2022-03-03 Intervet Int Bv Anticorpos caninizados para ctla-4 humana

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014512809A (ja) 2011-03-09 2014-05-29 アンチトープ・リミテッド ヒト化抗ｃｔｌａ４抗体
JP2017500867A (ja) 2013-12-20 2017-01-12 インターベット インターナショナル ベー． フェー． ヒトｐｄ−１に対するイヌ化マウス抗体
JP2017534267A (ja) 2014-09-30 2017-11-24 インターベット インターナショナル ベー． フェー． イヌｐｄ−ｌ１と結合するｐｄ−ｌ１抗体
WO2017062615A2 (en) 2015-10-08 2017-04-13 Macrogenics, Inc. Combination therapy for the treatment of cancer
JP2019506146A (ja) 2015-12-18 2019-03-07 インターベット インターナショナル ベー． フェー． ヒトおよびイヌｉｌ−４ｒアルファに対するイヌ化ヒト抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PLoS ONE，2018年，Vol.13, No.7: e0201222，pp.1-14

Also Published As

Publication number Publication date
BR112022000604A2 (pt) 2022-03-03
CN114174336A (zh) 2022-03-11
EP3999539A1 (en) 2022-05-25
CA3145347A1 (en) 2021-01-21
AU2020312687A1 (en) 2022-01-27
JP2025081549A (ja) 2025-05-27
CN114174336B (zh) 2024-10-11
US20220251209A1 (en) 2022-08-11
JP2022541767A (ja) 2022-09-27
CN119307505A (zh) 2025-01-14
WO2021009188A1 (en) 2021-01-21

Similar Documents

Publication Publication Date Title
US10927172B2 (en) Caninized murine antibodies to human PD-1
JP7695228B2 (ja) ヒト及びイヌｃｔｌａ－４に対するイヌ化抗体
EP3390451B1 (en) Caninized human antibodies to human and canine il-4r alpha
JP2025159730A (ja) イヌｃｔｌａ－４に対するイヌ化抗体
RU2822460C2 (ru) Канинизированные антитела против человеческого ctla-4
RU2818586C2 (ru) Антитела против собачьего ctla-4

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240521

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240820

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20241022

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250220

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250527

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250606

R150 Certificate of patent or registration of utility model

Ref document number: 7695228

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150