JP7690468B2 - 多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ - Google Patents

多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ Download PDF

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JP7690468B2
JP7690468B2 JP2022523456A JP2022523456A JP7690468B2 JP 7690468 B2 JP7690468 B2 JP 7690468B2 JP 2022523456 A JP2022523456 A JP 2022523456A JP 2022523456 A JP2022523456 A JP 2022523456A JP 7690468 B2 JP7690468 B2 JP 7690468B2
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antibody
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car
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JP2022552875A (ja
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ミッチェル ホー，
ルイシュエ ワン，
クロイ， ブラッドリー セント
ダン リー，
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US Department of Health and Human Services
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/54—Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

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JP2022523456A 2019-10-22 2020-10-21 多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ Active JP7690468B2 (ja)

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JP2025089701A JP2025116128A (ja) 2019-10-22 2025-05-29 多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ

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US201962924298P 2019-10-22 2019-10-22
US62/924,298 2019-10-22
PCT/US2020/056601 WO2021081052A1 (en) 2019-10-22 2020-10-21 High affinity nanobodies targeting b7h3 (cd276) for treating multiple solid tumors

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JP2025089701A Pending JP2025116128A (ja) 2019-10-22 2025-05-29 多様な固形腫瘍を処置するためのｂ７ｈ３（ｃｄ２７６）を標的とする高親和性ナノボディ

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WO2023274384A1 (zh) * 2021-07-01 2023-01-05 宁波茂行生物医药科技有限公司 靶向b7h3的抗原结合多肽及其应用
WO2023281445A1 (en) * 2021-07-07 2023-01-12 Technophage, Investigação E Desenvolvimento Em Biotecnologia, S.A. Highly specific rabbit single -domain antibodies for drug delivery in immunotherapy applications
JP2024534263A (ja) * 2021-08-27 2024-09-18 セラノティックス カンパニー リミテッド Ｂ７－Ｈ３及びＴＧＦβに特異的に結合する二重特異性分子、並びにその用途
WO2023173393A1 (zh) * 2022-03-18 2023-09-21 北京天广实生物技术股份有限公司 结合b7-h3的抗体及其用途
JP2025522557A (ja) * 2022-06-23 2025-07-15 フォートビタ バイオロジクス（シンガポール）プライベート リミティド Ｅｇｆｒおよびｂ７－ｈ３に結合する二重特異性抗体
KR20250059415A (ko) * 2022-08-08 2025-05-02 티크바 알로셀 피티이. 엘티디. B7-h3 항원-결합 분자
KR20250075604A (ko) * 2022-09-22 2025-05-28 상하이 헨리우스 바이오테크, 인크. 항-b7h3 항체 및 사용 방법
WO2024061297A1 (en) * 2022-09-22 2024-03-28 Shanghai Henlius Biotech , Inc. Anti-b7h3 antibodies, multispecific antibodies and methods of use
KR20250099721A (ko) * 2022-11-04 2025-07-02 티-맥시멈 파마슈티컬 (수저우) 컴퍼니 리미티드 B7h3을 표적으로 하는 범용형 car-t 세포 및 이의 제조 방법과 응용
IT202200025596A1 (it) * 2022-12-14 2024-06-14 Ospedale Pediatrico Bambino Gesù Cellule effettrici con recettore chimerico di antigene specifico per B7-H3 (B7-H3 CAR) derivate da IgG per il trattamento di tumori CD276+ e delle malattie autoimmuni
IT202200025593A1 (it) * 2022-12-14 2024-06-14 Ospedale Pediatrico Bambino Gesù Cellule effettrici di recettore chimerico di antigene specifico per B7-H3 (B7-H3 CAR) derivate da IgMper il trattamento di tumori CD276+ e malattie autoimmuni
WO2024140932A1 (en) * 2022-12-29 2024-07-04 Beigene, Ltd. Anti-b7h3 antibodies and methods of use
CN116239691B (zh) * 2022-12-30 2024-04-02 兰州大学第二医院 一种抗b7-h3纳米抗体及其应用
TW202438527A (zh) * 2023-03-17 2024-10-01 瑞士商百濟神州瑞士有限責任公司 抗b7h3抗體以及其使用方法
AU2024295016A1 (en) 2023-07-20 2026-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors
CN119371533A (zh) * 2023-07-27 2025-01-28 四川大学 抗b7h3的纳米抗体及其用途
CN117024592B (zh) * 2023-08-24 2024-07-12 四川大学华西医院 抗b7h3抗体及其用途
CN118829656B (zh) * 2023-12-01 2026-04-24 苏州智核生物医药科技有限公司 B7h3结合多肽及其用途
CN120349414A (zh) * 2023-12-28 2025-07-22 博生吉医药科技(苏州)有限公司 抗cd276纳米抗体及其制备方法和应用
WO2025146081A1 (zh) * 2024-01-03 2025-07-10 北京泰德制药股份有限公司 B7-h3结合蛋白
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WO2026002282A1 (zh) * 2024-06-28 2026-01-02 羿尊生物医药（浙江）有限公司 针对和/或特异性结合b7-h3的纳米抗体
CN119306837B (zh) * 2024-10-15 2025-10-24 普飞(郑州高新技术产业开发区)生物科技有限公司 一种抗cd276的纳米抗体及其应用
WO2026086929A1 (zh) * 2024-10-24 2026-04-30 北京科诺信诚科技有限公司 靶向人b7h3的纳米抗体及其应用
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