JP7689116B2 - Ｐｄ１およびｖｅｇｆｒ２二重結合剤 - Google Patents

Ｐｄ１およびｖｅｇｆｒ２二重結合剤 Download PDF

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Publication number
JP7689116B2
JP7689116B2 JP2022521074A JP2022521074A JP7689116B2 JP 7689116 B2 JP7689116 B2 JP 7689116B2 JP 2022521074 A JP2022521074 A JP 2022521074A JP 2022521074 A JP2022521074 A JP 2022521074A JP 7689116 B2 JP7689116 B2 JP 7689116B2
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seq
amino acid
acid sequence
antibody
sequence comprises
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JP2022553908A (ja
JP2022553908A5 (https=
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ジェームズ ジョナサン フィンレー，ウィリアム
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オッティモ ファーマ リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/528—CH4 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2022521074A 2019-10-11 2020-10-09 Ｐｄ１およびｖｅｇｆｒ２二重結合剤 Active JP7689116B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025087525A JP2025134713A (ja) 2019-10-11 2025-05-26 Ｐｄ１およびｖｅｇｆｒ２二重結合剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1914747.9 2019-10-11
GB201914747A GB201914747D0 (en) 2019-10-11 2019-10-11 PD1 and vegfr2 dual-binding agents
GBGB2013180.1A GB202013180D0 (en) 2019-10-11 2020-08-24 Pd1 and vegfr2 dual-binding agents
GB2013180.1 2020-08-24
PCT/EP2020/078427 WO2021069670A1 (en) 2019-10-11 2020-10-09 Pd1 and vegfr2 dual-binding agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025087525A Division JP2025134713A (ja) 2019-10-11 2025-05-26 Ｐｄ１およびｖｅｇｆｒ２二重結合剤

Publications (3)

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JP2022553908A JP2022553908A (ja) 2022-12-27
JP2022553908A5 JP2022553908A5 (https=) 2023-10-17
JP7689116B2 true JP7689116B2 (ja) 2025-06-05

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JP2022521074A Active JP7689116B2 (ja) 2019-10-11 2020-10-09 Ｐｄ１およびｖｅｇｆｒ２二重結合剤
JP2025087525A Pending JP2025134713A (ja) 2019-10-11 2025-05-26 Ｐｄ１およびｖｅｇｆｒ２二重結合剤

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JP2025087525A Pending JP2025134713A (ja) 2019-10-11 2025-05-26 Ｐｄ１およびｖｅｇｆｒ２二重結合剤

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Country Link
US (2) US20240101674A1 (https=)
EP (3) EP4041763B1 (https=)
JP (2) JP7689116B2 (https=)
KR (1) KR20220091490A (https=)
CN (2) CN114981301B (https=)
AU (1) AU2020365021A1 (https=)
CA (2) CA3289307A1 (https=)
DK (1) DK4041763T3 (https=)
ES (1) ES3027238T3 (https=)
FI (1) FI4041763T3 (https=)
GB (2) GB201914747D0 (https=)
HR (1) HRP20250523T1 (https=)
HU (1) HUE071341T2 (https=)
IL (1) IL292158A (https=)
LT (1) LT4041763T (https=)
PL (1) PL4041763T3 (https=)
PT (1) PT4041763T (https=)
RS (1) RS66837B1 (https=)
SI (1) SI4041763T1 (https=)
WO (1) WO2021069670A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109053895B (zh) 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
GB201914747D0 (en) 2019-10-11 2019-11-27 Ultrahuman Eight Ltd PD1 and vegfr2 dual-binding agents
CN116143935A (zh) * 2021-11-22 2023-05-23 杭州翰思生物医药有限公司 重组抗体及其应用
WO2024032662A1 (zh) * 2022-08-09 2024-02-15 上海济煜医药科技有限公司 一种靶向pd-1和vegf的抗体及其应用
CN118620082A (zh) * 2023-03-10 2024-09-10 南京维立志博生物科技有限公司 靶向vegf途径和pd-1的双特异性抗原结合蛋白、其组合物和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085847A1 (zh) 2013-12-12 2015-06-18 上海恒瑞医药有限公司 Pd-1抗体、其抗原结合片段及其医药用途
WO2019170885A1 (en) 2018-03-08 2019-09-12 Ultrahuman Eight Limited Pd1 binding agents

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DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
RU2689760C2 (ru) * 2012-05-31 2019-05-30 Дженентек, Инк. Способы лечения рака с применением антагонистов аксиального связывания pd-1 и vegf антагонистов
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
WO2017055404A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific antibodies specific for pd1 and tim3
CN109893654B (zh) * 2017-12-11 2021-07-27 江苏恒瑞医药股份有限公司 Vegfr抑制剂治疗肿瘤的方法
GB201803746D0 (en) 2018-03-08 2018-04-25 Ultrahuman Eight Ltd PD1 binding agents
CN109053895B (zh) * 2018-08-30 2020-06-09 中山康方生物医药有限公司 抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
TWI822897B (zh) 2018-11-06 2023-11-21 大陸商江蘇恆瑞醫藥股份有限公司 一種抗pd-1抗體和法米替尼聯合在製備治療腫瘤的藥物中的用途
GB201914747D0 (en) 2019-10-11 2019-11-27 Ultrahuman Eight Ltd PD1 and vegfr2 dual-binding agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085847A1 (zh) 2013-12-12 2015-06-18 上海恒瑞医药有限公司 Pd-1抗体、其抗原结合片段及其医药用途
WO2019170885A1 (en) 2018-03-08 2019-09-12 Ultrahuman Eight Limited Pd1 binding agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cancer Res.，2016年，Vol. 76, Suupl. 14，Abstract No. 572

Also Published As

Publication number Publication date
PT4041763T (pt) 2025-05-16
EP4570824A2 (en) 2025-06-18
EP4671279A2 (en) 2025-12-31
EP4570824A3 (en) 2025-06-25
CN121758618A (zh) 2026-03-31
DK4041763T3 (da) 2025-05-19
RS66837B1 (sr) 2025-06-30
US20250243276A1 (en) 2025-07-31
AU2020365021A1 (en) 2022-05-26
US12479920B2 (en) 2025-11-25
SI4041763T1 (sl) 2025-08-29
WO2021069670A1 (en) 2021-04-15
KR20220091490A (ko) 2022-06-30
CN114981301A (zh) 2022-08-30
CA3289307A1 (en) 2026-03-02
EP4041763B1 (en) 2025-02-26
HUE071341T2 (hu) 2025-08-28
JP2025134713A (ja) 2025-09-17
HRP20250523T1 (hr) 2025-07-04
EP4041763A1 (en) 2022-08-17
GB201914747D0 (en) 2019-11-27
ES3027238T3 (en) 2025-06-13
GB202013180D0 (en) 2020-10-07
LT4041763T (lt) 2025-06-10
CA3156096A1 (en) 2021-04-15
IL292158A (en) 2022-06-01
FI4041763T3 (fi) 2025-05-15
US20240101674A1 (en) 2024-03-28
PL4041763T3 (pl) 2025-07-07
JP2022553908A (ja) 2022-12-27
CN114981301B (zh) 2026-04-14
CA3156096C (en) 2026-03-17

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