JP7685833B2 - 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 - Google Patents
翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 Download PDFInfo
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- JP7685833B2 JP7685833B2 JP2020517843A JP2020517843A JP7685833B2 JP 7685833 B2 JP7685833 B2 JP 7685833B2 JP 2020517843 A JP2020517843 A JP 2020517843A JP 2020517843 A JP2020517843 A JP 2020517843A JP 7685833 B2 JP7685833 B2 JP 7685833B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07—ORGANIC CHEMISTRY
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023077454A JP2023113641A (ja) | 2017-09-27 | 2023-05-09 | 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762564095P | 2017-09-27 | 2017-09-27 | |
| US62/564,095 | 2017-09-27 | ||
| US201762574657P | 2017-10-19 | 2017-10-19 | |
| US62/574,657 | 2017-10-19 | ||
| US201762579682P | 2017-10-31 | 2017-10-31 | |
| US62/579,682 | 2017-10-31 | ||
| US201862632812P | 2018-02-20 | 2018-02-20 | |
| US62/632,812 | 2018-02-20 | ||
| PCT/US2018/052855 WO2019067540A1 (en) | 2017-09-27 | 2018-09-26 | TREATMENT OF OCULAR DISEASES WITH A TOTALLY HUMAN POST-TRANSLATIONAL MODIFICATION ANTI-VEGF FAB |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023077454A Division JP2023113641A (ja) | 2017-09-27 | 2023-05-09 | 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535184A JP2020535184A (ja) | 2020-12-03 |
| JP2020535184A5 JP2020535184A5 (https=) | 2021-09-30 |
| JP7685833B2 true JP7685833B2 (ja) | 2025-05-30 |
Family
ID=65903176
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517843A Active JP7685833B2 (ja) | 2017-09-27 | 2018-09-26 | 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 |
| JP2023077454A Pending JP2023113641A (ja) | 2017-09-27 | 2023-05-09 | 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023077454A Pending JP2023113641A (ja) | 2017-09-27 | 2023-05-09 | 翻訳後修飾された完全ヒト抗VEGF Fabによる眼疾患の治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20200277364A1 (https=) |
| EP (1) | EP3687464A4 (https=) |
| JP (2) | JP7685833B2 (https=) |
| KR (2) | KR20250040754A (https=) |
| AU (2) | AU2018342094B2 (https=) |
| CA (1) | CA3076905A1 (https=) |
| IL (1) | IL273403A (https=) |
| SG (1) | SG11202002396TA (https=) |
| WO (1) | WO2019067540A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2916827B1 (en) | 2012-11-08 | 2020-06-10 | Clearside Biomedical Inc. | Methods for the treatment of ocular disease in human subjects |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| JP7046828B2 (ja) | 2016-04-15 | 2022-04-04 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 滲出型加齢性黄斑変性の治療のための組成物 |
| MX2020006435A (es) | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| US12558434B2 (en) | 2018-02-20 | 2026-02-24 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| US20220133908A1 (en) * | 2019-02-08 | 2022-05-05 | Curevac Ag | Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases |
| EP4667578A3 (en) * | 2019-04-03 | 2026-04-01 | REGENXBIO Inc. | Gene therapy for eye pathologies |
| CN118718181A (zh) | 2019-06-05 | 2024-10-01 | 里珍纳龙药品有限公司 | 用于精确剂量递送的装置及方法 |
| CN110423281B (zh) * | 2019-07-31 | 2021-04-30 | 成都金唯科生物科技有限公司 | 用于治疗老年性黄斑变性的融合蛋白、病毒载体和药物 |
| WO2021041373A1 (en) | 2019-08-26 | 2021-03-04 | Regenxbio Inc. | Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab |
| AU2020362119A1 (en) | 2019-10-07 | 2022-05-26 | Regenxbio Inc. | Adeno-associated virus vector pharmaceutical composition and methods |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20230201371A1 (en) * | 2020-03-19 | 2023-06-29 | Clearside Biomedical, Inc. | Compositions and methods for treating ocular disorders |
| CN116234917A (zh) | 2020-07-27 | 2023-06-06 | 安杰瑞姆生物科学公司 | Dna分子组合物及其制备方法和使用方法 |
| US20230372538A1 (en) * | 2020-10-07 | 2023-11-23 | Regenxbio Inc. | Formulations for suprachoroidal administration such as formulations with aggregate formation |
| IL303317A (en) | 2020-12-01 | 2023-07-01 | Akouos Inc | ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA |
| WO2022165313A1 (en) | 2021-02-01 | 2022-08-04 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
| EP4401836A1 (en) * | 2021-09-18 | 2024-07-24 | Skyline Therapeutics Limited | Aav for the gene therapy of wet-amd |
| CN116925234B (zh) * | 2022-04-02 | 2024-05-31 | 合肥星眸生物科技有限公司 | 一种编码抗vegf-a和ang-2双特异性抗体的aav载体 |
| IL319873A (en) | 2022-09-30 | 2025-05-01 | Regenxbio Inc | Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
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| US6943153B1 (en) * | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US20070202186A1 (en) * | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| KR20140014405A (ko) * | 2009-05-28 | 2014-02-06 | 글락소 그룹 리미티드 | 안구 질병을 치료하거나 예방하는데 사용되는 tnf-알파 길항제 및 vegf 길항제의 조합물 |
| PE20120622A1 (es) * | 2009-06-17 | 2012-05-26 | Abbott Biotherapeutics Corp | Anticuerpos anti-vegf y sus usos |
| EP2559443A1 (en) * | 2011-08-16 | 2013-02-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject |
| TWI775096B (zh) * | 2012-05-15 | 2022-08-21 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| JP2016531149A (ja) * | 2013-09-11 | 2016-10-06 | ニューロテック ユーエスエー, インコーポレイテッド | カプセル化細胞療法カートリッジ |
| US10064752B2 (en) * | 2014-09-11 | 2018-09-04 | Orbit Biomedical Limited | Motorized suprachoroidal injection of therapeutic agent |
| CN108778330A (zh) * | 2016-01-08 | 2018-11-09 | 科尼尔赛德生物医学公司 | 用阿柏西普和其他生物制品治疗后眼部障碍的方法和装置 |
| WO2017181021A1 (en) * | 2016-04-15 | 2017-10-19 | Regenxbio Inc. | Treatment of ocular diseases with fully-human post-translationally modified anti-vegf fab |
| JP7046828B2 (ja) * | 2016-04-15 | 2022-04-04 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 滲出型加齢性黄斑変性の治療のための組成物 |
| US12558434B2 (en) * | 2018-02-20 | 2026-02-24 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US20230201371A1 (en) * | 2020-03-19 | 2023-06-29 | Clearside Biomedical, Inc. | Compositions and methods for treating ocular disorders |
-
2018
- 2018-09-26 SG SG11202002396TA patent/SG11202002396TA/en unknown
- 2018-09-26 CA CA3076905A patent/CA3076905A1/en active Pending
- 2018-09-26 EP EP18862872.1A patent/EP3687464A4/en active Pending
- 2018-09-26 JP JP2020517843A patent/JP7685833B2/ja active Active
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Non-Patent Citations (9)
| Title |
|---|
| 12 Drug Delivery to the Suprachoroidal Space, Ocular Drug Delivery Systems, 2012, 235-258 |
| Invest Ophthalmol Vis Sci, 2014, Vol. 55, pp. 2714-2730 |
| Investigative Ophthalmology & Visual Science, 2012, Vol. 53, No. 8, pp. 4433-4441 |
| Investigative Ophthalmology & Visual Science, ARVO Annual Meeting Abstract, 2012, Vol. 53, 1931 |
| Investigative Ophthalmology & Visual Science, ARVO Annual Meeting Abstract, 2015, Vol. 56, 259 |
| Investigative Ophthalmology & Visual Science, June 2017, Vol. 58, p.4509, ARVO annual meeting abstract |
| Molecular Therapy, 2012, Volume 20, Supplement 1, S31 |
| Molecular Therapy, 2016, Volume 24, Supplement 1, S217-218, 544 |
| PLos One, 2011, Vol. 6, Issue. 2, e17140 |
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| US20240254214A1 (en) | 2024-08-01 |
| IL273403A (en) | 2020-05-31 |
| KR20250040754A (ko) | 2025-03-24 |
| US20250320287A1 (en) | 2025-10-16 |
| AU2018342094A1 (en) | 2020-04-02 |
| KR20200060456A (ko) | 2020-05-29 |
| EP3687464A1 (en) | 2020-08-05 |
| JP2020535184A (ja) | 2020-12-03 |
| SG11202002396TA (en) | 2020-04-29 |
| CA3076905A1 (en) | 2019-04-04 |
| AU2025203154A1 (en) | 2025-05-22 |
| EP3687464A4 (en) | 2021-09-29 |
| WO2019067540A1 (en) | 2019-04-04 |
| AU2018342094B2 (en) | 2025-02-06 |
| US20200277364A1 (en) | 2020-09-03 |
| JP2023113641A (ja) | 2023-08-16 |
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