JP7682859B2 - 前立腺幹細胞抗原（ｐｓｃａ）キメラ抗原受容体（ｃａｒ）を含む組成物および方法 - Google Patents

前立腺幹細胞抗原（ｐｓｃａ）キメラ抗原受容体（ｃａｒ）を含む組成物および方法 Download PDF

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JP7682859B2
JP7682859B2 JP2022515826A JP2022515826A JP7682859B2 JP 7682859 B2 JP7682859 B2 JP 7682859B2 JP 2022515826 A JP2022515826 A JP 2022515826A JP 2022515826 A JP2022515826 A JP 2022515826A JP 7682859 B2 JP7682859 B2 JP 7682859B2
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ヤンビン チャオ
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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JP2022515826A 2019-09-11 2020-09-10 前立腺幹細胞抗原（ｐｓｃａ）キメラ抗原受容体（ｃａｒ）を含む組成物および方法 Active JP7682859B2 (ja)

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US201962898896P 2019-09-11 2019-09-11
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US202062985808P 2020-03-05 2020-03-05
US62/985,808 2020-03-05
PCT/US2020/050090 WO2021050656A1 (en) 2019-09-11 2020-09-10 Compositions and methods comprising prostate stem cell antigen (psca) chimeric antigen receptors (cars)

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CN117843812A (zh) * 2020-05-22 2024-04-09 重庆精准生物技术有限公司 逆转肿瘤微环境的融合蛋白及其应用
CA3231670A1 (en) * 2021-09-10 2023-03-16 Kite Pharma, Inc. Alternative generation of allogeneic human t cells
EP4479068A4 (en) * 2022-02-18 2026-01-07 Univ California ENHANCED MULTIPLICATION AND FUNCTION OF PRIMARY HUMAN NK CELLS BY A CHIMERICAL CYTOKINE RECEPTOR
WO2024040195A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向ｐｓｍａ及ｃａ９之系統
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025235801A1 (en) 2024-05-08 2025-11-13 City Of Hope Antibodies targeted to osteopontin and uses thereof for reducing resistance of solid tumors immune cell therapy

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008529556A (ja) 2005-02-18 2008-08-07 メダレックス， インク． 前立腺特異的膜抗原（ｐｓｍａ）に対するヒトモノクローナル抗体
JP2010538080A (ja) 2007-09-04 2010-12-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体
JP2012504402A (ja) 2008-10-01 2012-02-23 マイクロメット アーゲー ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体
JP2015513399A (ja) 2012-02-22 2015-05-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌の治療のために有用なｔ細胞の存続的集団を作製するための組成物および方法
JP2015524255A (ja) 2012-07-13 2015-08-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法
JP2015531242A (ja) 2012-10-10 2015-11-02 サンガモ バイオサイエンシーズ， インコーポレイテッド Ｔ細胞を修飾する化合物およびその使用
JP2016515810A (ja) 2013-03-15 2016-06-02 アントフロゲネシス コーポレーション 修飾されたｔリンパ球
JP2017513818A (ja) 2014-03-15 2017-06-01 ノバルティス アーゲー キメラ抗原受容体を使用する癌の処置
JP2018530333A (ja) 2015-10-06 2018-10-18 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Ｐｓｃａを標的とするキメラ抗原レセプター
US20190055297A1 (en) 2017-04-13 2019-02-21 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy
CN109593726A (zh) 2018-12-26 2019-04-09 重庆精准生物技术有限公司 增强car-t细胞归巢到实体肿瘤组织能力的试剂及其应用
US20190247432A1 (en) 2017-12-12 2019-08-15 The Trustees Of The University Of Pennsylvania Genetically Modified Immune Cells Targeting NY-ESO-1 and Methods of Use Thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3212225T3 (pl) * 2014-10-31 2026-03-30 The Trustees Of The University Of Pennsylvania Sposoby i kompozycje zmodyfikowanych limfocytów t
CN117534764A (zh) 2016-06-06 2024-02-09 阿布泽纳(英国)有限公司 抗体、其用途及其缀合物
GB201614162D0 (en) 2016-08-18 2016-10-05 Polytherics Ltd Antibodies, uses thereof and conjugates thereof
CN108395480A (zh) 2017-02-08 2018-08-14 广州百尼夫生物科技有限公司 嵌合抗原受体及其基因和重组表达载体、carher2-nkt细胞及其制备方法和应用
SG11201908784TA (en) * 2017-03-27 2019-10-30 Hoffmann La Roche Improved antigen binding receptor formats

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008529556A (ja) 2005-02-18 2008-08-07 メダレックス， インク． 前立腺特異的膜抗原（ｐｓｍａ）に対するヒトモノクローナル抗体
JP2010538080A (ja) 2007-09-04 2010-12-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原（ｐｓｃａ）抗体
JP2012504402A (ja) 2008-10-01 2012-02-23 マイクロメット アーゲー ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体
JP2015513399A (ja) 2012-02-22 2015-05-14 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌の治療のために有用なｔ細胞の存続的集団を作製するための組成物および方法
JP2015524255A (ja) 2012-07-13 2015-08-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 二重特異性抗体を共導入することによってｃａｒｔ細胞の活性を強化する方法
JP2015531242A (ja) 2012-10-10 2015-11-02 サンガモ バイオサイエンシーズ， インコーポレイテッド Ｔ細胞を修飾する化合物およびその使用
JP2016515810A (ja) 2013-03-15 2016-06-02 アントフロゲネシス コーポレーション 修飾されたｔリンパ球
JP2017513818A (ja) 2014-03-15 2017-06-01 ノバルティス アーゲー キメラ抗原受容体を使用する癌の処置
JP2018530333A (ja) 2015-10-06 2018-10-18 シティ・オブ・ホープＣｉｔｙ ｏｆ Ｈｏｐｅ Ｐｓｃａを標的とするキメラ抗原レセプター
US20190055297A1 (en) 2017-04-13 2019-02-21 The Trustees Of The University Of Pennsylvania Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy
US20190247432A1 (en) 2017-12-12 2019-08-15 The Trustees Of The University Of Pennsylvania Genetically Modified Immune Cells Targeting NY-ESO-1 and Methods of Use Thereof
CN109593726A (zh) 2018-12-26 2019-04-09 重庆精准生物技术有限公司 增强car-t细胞归巢到实体肿瘤组织能力的试剂及其应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Human Gene Therapy，2014年，Vol.25，pp.1003-1012

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EP4028414A4 (en) 2024-01-17
US20210069239A1 (en) 2021-03-11
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