JP7670834B2 - アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法 - Google Patents

アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法 Download PDF

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JP7670834B2
JP7670834B2 JP2023540087A JP2023540087A JP7670834B2 JP 7670834 B2 JP7670834 B2 JP 7670834B2 JP 2023540087 A JP2023540087 A JP 2023540087A JP 2023540087 A JP2023540087 A JP 2023540087A JP 7670834 B2 JP7670834 B2 JP 7670834B2
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sensor
analyte
certain embodiments
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JP2024501863A (ja
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リウ、ゼンホァ
エス． クロイツ、バリー
ラージ オジャ、ヤグヤ
ジェイ． フェルドマン、ベンジャミン
ピー． リアリー、トーマス
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Abbott Diabetes Care Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
JP2023540087A 2020-12-30 2021-12-23 アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法 Active JP7670834B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025067818A JP2025105651A (ja) 2020-12-30 2025-04-17 アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法

Applications Claiming Priority (3)

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US202063132200P 2020-12-30 2020-12-30
US63/132,200 2020-12-30
PCT/US2021/065141 WO2022146888A1 (en) 2020-12-30 2021-12-23 Analyte sensors for detecting asparagine and aspartate and methods of use thereof

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JP2025067818A Division JP2025105651A (ja) 2020-12-30 2025-04-17 アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法

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JP2024501863A JP2024501863A (ja) 2024-01-16
JP7670834B2 true JP7670834B2 (ja) 2025-04-30

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JP2025067818A Pending JP2025105651A (ja) 2020-12-30 2025-04-17 アスパラギン及びアスパラギン酸塩を検出するための被検物質センサ及びその使用方法

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US (2) US12345671B2 (https=)
EP (1) EP4271825A1 (https=)
JP (2) JP7670834B2 (https=)
CN (1) CN117098852A (https=)
WO (1) WO2022146888A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4655412A2 (en) * 2023-01-25 2025-12-03 Abbott Diabetes Care, Inc. Temperature-insensitive membranes for analyte sensors
WO2024197225A1 (en) * 2023-03-22 2024-09-26 President And Fellows Of Harvard College Redox active antifouling coatings

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US20130324820A1 (en) 2010-12-01 2013-12-05 Pinnacle Technology, Inc. Tissue implantable microbiosensor
US20190090797A1 (en) 2017-09-28 2019-03-28 California Institute Of Technology Switchable low voltage electrochemical sensing for interfering species rejection
US20200237275A1 (en) 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones
JP2020526748A (ja) 2017-06-30 2020-08-31 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 電気化学バイオセンサーを用いた検体検出のための方法及び装置
JP2020202825A (ja) 2019-06-12 2020-12-24 王子ホールディングス株式会社 酵素固定化体及びそれを備えた測定装置ならびにアスパラギン及びｌ−アスパラギン酸の測定方法

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US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
US8268143B2 (en) 1999-11-15 2012-09-18 Abbott Diabetes Care Inc. Oxygen-effect free analyte sensor
DE60035123T2 (de) 1999-11-15 2008-01-31 Therasense, Inc., Alameda Übergangsmetallkomplexe, die über ein bewegliches zwischenglied an ein polymer gebunden sind
US7769420B2 (en) * 2000-05-15 2010-08-03 Silver James H Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US7501053B2 (en) 2002-10-23 2009-03-10 Abbott Laboratories Biosensor having improved hematocrit and oxygen biases
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US20170367627A1 (en) * 2004-07-13 2017-12-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2010033741A1 (en) * 2008-09-19 2010-03-25 Bayer Healthcare Llc Analyte sensors, systems, testing apparatus and manufacturing methods
FI3912551T3 (fi) 2009-02-26 2023-10-31 Abbott Diabetes Care Inc Parannettuja analyyttiantureita ja menetelmiä niiden valmistamiseksi ja käyttämiseksi
FI2720610T3 (fi) * 2011-06-17 2025-09-30 Abbott Diabetes Care Inc Pinottu analyyttianturi, jonka ensimmäinen elektrodi on kapeampi kuin anturin toinen elektrodi
FI3300658T3 (fi) 2011-12-11 2024-03-01 Abbott Diabetes Care Inc Analyyttianturimenetelmiä
WO2014099907A1 (en) 2012-12-18 2014-06-26 Abbott Diabetes Care Inc. Dermal layer analyte sensing devices and methods
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CN119924827A (zh) 2018-06-07 2025-05-06 雅培糖尿病护理公司 用于分析物监测系统的聚焦灭菌和已灭菌的子组件
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130324820A1 (en) 2010-12-01 2013-12-05 Pinnacle Technology, Inc. Tissue implantable microbiosensor
JP2020526748A (ja) 2017-06-30 2020-08-31 アボット ダイアベティス ケア インコーポレイテッドＡｂｂｏｔｔ Ｄｉａｂｅｔｅｓ Ｃａｒｅ Ｉｎｃ． 電気化学バイオセンサーを用いた検体検出のための方法及び装置
US20190090797A1 (en) 2017-09-28 2019-03-28 California Institute Of Technology Switchable low voltage electrochemical sensing for interfering species rejection
US20200237275A1 (en) 2019-01-28 2020-07-30 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones
JP2020202825A (ja) 2019-06-12 2020-12-24 王子ホールディングス株式会社 酵素固定化体及びそれを備えた測定装置ならびにアスパラギン及びｌ−アスパラギン酸の測定方法

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Publication number Publication date
JP2025105651A (ja) 2025-07-10
WO2022146888A9 (en) 2023-08-03
WO2022146888A1 (en) 2022-07-07
US20220205944A1 (en) 2022-06-30
CN117098852A (zh) 2023-11-21
US20250347647A1 (en) 2025-11-13
EP4271825A1 (en) 2023-11-08
US12345671B2 (en) 2025-07-01
JP2024501863A (ja) 2024-01-16

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