CN117098852A - 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 - Google Patents

用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 Download PDF

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Publication number
CN117098852A
CN117098852A CN202180094850.0A CN202180094850A CN117098852A CN 117098852 A CN117098852 A CN 117098852A CN 202180094850 A CN202180094850 A CN 202180094850A CN 117098852 A CN117098852 A CN 117098852A
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CN
China
Prior art keywords
sensor
analyte
certain embodiments
asparagine
active region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180094850.0A
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English (en)
Chinese (zh)
Inventor
刘增何
B·S·克鲁兹
Y·R·奥贾哈
B·J·弗尔德曼
T·P·利瑞
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Abbott Diabetes Care Co
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Abbott Diabetes Care Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Diabetes Care Co filed Critical Abbott Diabetes Care Co
Publication of CN117098852A publication Critical patent/CN117098852A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CN202180094850.0A 2020-12-30 2021-12-23 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法 Pending CN117098852A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063132200P 2020-12-30 2020-12-30
US63/132,200 2020-12-30
PCT/US2021/065141 WO2022146888A1 (en) 2020-12-30 2021-12-23 Analyte sensors for detecting asparagine and aspartate and methods of use thereof

Publications (1)

Publication Number Publication Date
CN117098852A true CN117098852A (zh) 2023-11-21

Family

ID=80225723

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180094850.0A Pending CN117098852A (zh) 2020-12-30 2021-12-23 用于检测天冬酰胺和天冬氨酸的分析物传感器及其使用方法

Country Status (5)

Country Link
US (2) US12345671B2 (https=)
EP (1) EP4271825A1 (https=)
JP (2) JP7670834B2 (https=)
CN (1) CN117098852A (https=)
WO (1) WO2022146888A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4655412A2 (en) * 2023-01-25 2025-12-03 Abbott Diabetes Care, Inc. Temperature-insensitive membranes for analyte sensors
WO2024197225A1 (en) * 2023-03-22 2024-09-26 President And Fellows Of Harvard College Redox active antifouling coatings

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6736957B1 (en) 1997-10-16 2004-05-18 Abbott Laboratories Biosensor electrode mediators for regeneration of cofactors and process for using
US6134461A (en) 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US8444834B2 (en) 1999-11-15 2013-05-21 Abbott Diabetes Care Inc. Redox polymers for use in analyte monitoring
US8268143B2 (en) 1999-11-15 2012-09-18 Abbott Diabetes Care Inc. Oxygen-effect free analyte sensor
DE60035123T2 (de) 1999-11-15 2008-01-31 Therasense, Inc., Alameda Übergangsmetallkomplexe, die über ein bewegliches zwischenglied an ein polymer gebunden sind
US7769420B2 (en) * 2000-05-15 2010-08-03 Silver James H Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
US6932894B2 (en) 2001-05-15 2005-08-23 Therasense, Inc. Biosensor membranes composed of polymers containing heterocyclic nitrogens
US7501053B2 (en) 2002-10-23 2009-03-10 Abbott Laboratories Biosensor having improved hematocrit and oxygen biases
US8165651B2 (en) 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US20170367627A1 (en) * 2004-07-13 2017-12-28 Dexcom, Inc. Transcutaneous analyte sensor
WO2010033741A1 (en) * 2008-09-19 2010-03-25 Bayer Healthcare Llc Analyte sensors, systems, testing apparatus and manufacturing methods
FI3912551T3 (fi) 2009-02-26 2023-10-31 Abbott Diabetes Care Inc Parannettuja analyyttiantureita ja menetelmiä niiden valmistamiseksi ja käyttämiseksi
US9468402B2 (en) 2010-12-01 2016-10-18 Pinnacle Technology, Inc. Tissue implantable microbiosensor
FI2720610T3 (fi) * 2011-06-17 2025-09-30 Abbott Diabetes Care Inc Pinottu analyyttianturi, jonka ensimmäinen elektrodi on kapeampi kuin anturin toinen elektrodi
FI3300658T3 (fi) 2011-12-11 2024-03-01 Abbott Diabetes Care Inc Analyyttianturimenetelmiä
WO2014099907A1 (en) 2012-12-18 2014-06-26 Abbott Diabetes Care Inc. Dermal layer analyte sensing devices and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
CA3050721A1 (en) 2017-01-23 2018-07-26 Abbott Diabetes Care Inc. Systems, devices and methods for analyte sensor insertion
EP4538692A3 (en) 2017-06-30 2025-06-18 Abbott Diabetes Care Method and apparatus for analyte detection using an electrochemical biosensor
DE202018006591U1 (de) 2017-08-18 2021-07-21 Abbott Diabetes Care, Inc. Systeme und Vorrichtungen betreffend die individualisierte Kalibrierung und/oder Herstellung von medizinischen Vorrichtungen
US11903708B2 (en) 2017-09-28 2024-02-20 California Institute Of Technology Switchable low voltage electrochemical sensing for interfering species rejection
DE202019005660U1 (de) 2018-06-07 2021-07-12 Abbott Diabetes Care, Inc. Fokussierte Sterilisation und sterilisierte Teilanordnungen für Analytüberwachungssysteme
CN119924827A (zh) 2018-06-07 2025-05-06 雅培糖尿病护理公司 用于分析物监测系统的聚焦灭菌和已灭菌的子组件
CN113195022A (zh) 2018-12-21 2021-07-30 雅培糖尿病护理公司 用于分析物传感器插入的系统、装置和方法
CA3126240A1 (en) 2019-01-28 2020-08-06 Abbott Diabetes Cares Inc. Analyte sensors employing multiple enzymes and methods associated therewith
EP4574038A3 (en) 2019-01-28 2025-08-27 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones
JP7748059B2 (ja) 2019-06-12 2025-10-02 王子ホールディングス株式会社 酵素固定化体及びそれを備えた測定装置ならびにアスパラギン及びｌ－アスパラギン酸の測定方法

Also Published As

Publication number Publication date
JP2025105651A (ja) 2025-07-10
WO2022146888A9 (en) 2023-08-03
WO2022146888A1 (en) 2022-07-07
US20220205944A1 (en) 2022-06-30
US20250347647A1 (en) 2025-11-13
EP4271825A1 (en) 2023-11-08
JP7670834B2 (ja) 2025-04-30
US12345671B2 (en) 2025-07-01
JP2024501863A (ja) 2024-01-16

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