JP7665261B2 - 新規ｌｒｐ１結合ペプチド - Google Patents

新規ｌｒｐ１結合ペプチド Download PDF

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Publication number
JP7665261B2
JP7665261B2 JP2024538862A JP2024538862A JP7665261B2 JP 7665261 B2 JP7665261 B2 JP 7665261B2 JP 2024538862 A JP2024538862 A JP 2024538862A JP 2024538862 A JP2024538862 A JP 2024538862A JP 7665261 B2 JP7665261 B2 JP 7665261B2
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JP
Japan
Prior art keywords
group
peptide
amino acid
acid
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2024538862A
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English (en)
Japanese (ja)
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JPWO2024029242A5 (https=
JPWO2024029242A1 (https=
Inventor
孝太郎 坂元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichimaru Pharcos Co Ltd
Original Assignee
Ichimaru Pharcos Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ichimaru Pharcos Co Ltd filed Critical Ichimaru Pharcos Co Ltd
Publication of JPWO2024029242A1 publication Critical patent/JPWO2024029242A1/ja
Publication of JPWO2024029242A5 publication Critical patent/JPWO2024029242A5/ja
Priority to JP2025061336A priority Critical patent/JP2025102922A/ja
Application granted granted Critical
Publication of JP7665261B2 publication Critical patent/JP7665261B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024538862A 2022-08-05 2023-06-29 新規ｌｒｐ１結合ペプチド Active JP7665261B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025061336A JP2025102922A (ja) 2022-08-05 2025-04-02 新規ｌｒｐ１結合ペプチド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022125238 2022-08-05
JP2022125238 2022-08-05
PCT/JP2023/024137 WO2024029242A1 (ja) 2022-08-05 2023-06-29 新規ｌｒｐ１結合ペプチド

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025061336A Division JP2025102922A (ja) 2022-08-05 2025-04-02 新規ｌｒｐ１結合ペプチド

Publications (3)

Publication Number Publication Date
JPWO2024029242A1 JPWO2024029242A1 (https=) 2024-02-08
JPWO2024029242A5 JPWO2024029242A5 (https=) 2024-10-08
JP7665261B2 true JP7665261B2 (ja) 2025-04-21

Family

ID=89848802

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2024538862A Active JP7665261B2 (ja) 2022-08-05 2023-06-29 新規ｌｒｐ１結合ペプチド
JP2025061336A Pending JP2025102922A (ja) 2022-08-05 2025-04-02 新規ｌｒｐ１結合ペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025061336A Pending JP2025102922A (ja) 2022-08-05 2025-04-02 新規ｌｒｐ１結合ペプチド

Country Status (4)

Country Link
EP (1) EP4541891A1 (https=)
JP (2) JP7665261B2 (https=)
CN (1) CN119630790A (https=)
WO (1) WO2024029242A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7713129B1 (ja) * 2023-12-28 2025-07-24 一丸ファルコス株式会社 組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015526434A (ja) 2012-08-14 2015-09-10 アンジオケム インコーポレーテッド ペプチド−デンドリマーコンジュゲート及びその使用
JP2022033027A (ja) 2020-08-11 2022-02-25 アプライド マテリアルズ イスラエル リミテッド ウエハ分析のための較正データを生成する方法およびシステム

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7110800B2 (ja) 2018-07-31 2022-08-02 株式会社三洋物産 遊技機
CA3128035A1 (en) * 2020-08-13 2022-02-13 Bioasis Technologies, Inc. Combination therapies for delivery across the blood brain barrier

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015526434A (ja) 2012-08-14 2015-09-10 アンジオケム インコーポレーテッド ペプチド−デンドリマーコンジュゲート及びその使用
JP2022033027A (ja) 2020-08-11 2022-02-25 アプライド マテリアルズ イスラエル リミテッド ウエハ分析のための較正データを生成する方法およびシステム

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDRE Severine et al.，Development of an LDL Receptor-Targeted Peptide Susceptible to Facilitate the Brain Access of Diagno，Biology，2020年，Vol.9，161，doi:10.3390/biology9070161
RUAN Huitong et al.，Stapled RAP12 peptide ligand of LRP1 for micelles-based multifunctional glioma-targeted drug deliver，Chemical Engineering Journal，2021年，Vol.403，126296，doi:10.1016/j.cej.2020.126296
SAKAMOTO Kotaro，Generation of KS-487 as a novel LRP1-binding cyclic peptide with higher affinity, higher stability and BBB permeability，Biochemistry and Biophysics Reports，2022年10月08日，Vol.32，101367，doi:10.1016/j.bbrep.2022.101367

Also Published As

Publication number Publication date
EP4541891A1 (en) 2025-04-23
JPWO2024029242A1 (https=) 2024-02-08
WO2024029242A1 (ja) 2024-02-08
JP2025102922A (ja) 2025-07-08
CN119630790A (zh) 2025-03-14

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