JP7665122B2 - ハロアリルアミン系二重アミンオキシダーゼ阻害剤 - Google Patents

ハロアリルアミン系二重アミンオキシダーゼ阻害剤 Download PDF

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JP7665122B2
JP7665122B2 JP2022578773A JP2022578773A JP7665122B2 JP 7665122 B2 JP7665122 B2 JP 7665122B2 JP 2022578773 A JP2022578773 A JP 2022578773A JP 2022578773 A JP2022578773 A JP 2022578773A JP 7665122 B2 JP7665122 B2 JP 7665122B2
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disease
mao
compound
vap
ssao
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JP2023531468A5 (https=
JP2023531468A (ja
Inventor
ダンカン ロバートソン，アラン
ドロシー フィンドレー，アリソン
ブソン，アルベルト
イヴァン ターナー，クレイグ
ウルフギャング ハンプレヒト，ディーター
スチュアート フット，ジョナサン
デオダール，マンダル
ジャロリメック，ウルフギャング
ベッキ，セレーナ
ウォルター バレイン，バーナード
カントン，マルチェッラ
ヴィティエッロ，リベロ
ブラウ，バート
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シンタラ リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022578773A 2020-06-26 2021-06-25 ハロアリルアミン系二重アミンオキシダーゼ阻害剤 Active JP7665122B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020902152A AU2020902152A0 (en) 2020-06-26 Haloallyamine dual amine oxidase inhibitors
AU2020902152 2020-06-26
PCT/AU2021/050675 WO2021258159A1 (en) 2020-06-26 2021-06-25 Haloallylamine dual amine oxidase inhibitors

Publications (3)

Publication Number Publication Date
JP2023531468A JP2023531468A (ja) 2023-07-24
JP2023531468A5 JP2023531468A5 (https=) 2024-06-11
JP7665122B2 true JP7665122B2 (ja) 2025-04-21

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JP2022578773A Active JP7665122B2 (ja) 2020-06-26 2021-06-25 ハロアリルアミン系二重アミンオキシダーゼ阻害剤

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Country Link
US (1) US12428370B2 (https=)
EP (1) EP4171740A4 (https=)
JP (1) JP7665122B2 (https=)
CN (1) CN115916337B (https=)
WO (1) WO2021258159A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250022712A (ko) * 2022-05-30 2025-02-17 기초과학연구원 모노아민 산화효소 b에 대한 안티센스 올리고머 및 이의 용도
AU2023331414A1 (en) * 2022-08-29 2025-03-27 Syntara Limited Novel selective inhibitors of lysyl oxidases
KR20250174618A (ko) * 2023-03-22 2025-12-12 쿠보타 비전 인코포레이티드 신경 염증의 치료

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504485A (ja) 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
JP2015521167A (ja) 2012-05-02 2015-07-27 ファームアクシス・リミテッドＰｈａｒｍａｘｉｓ Ｌｔｄ Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用
CN109251166A (zh) 2017-07-13 2019-01-22 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2019024924A1 (zh) 2017-08-04 2019-02-07 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2020006177A1 (en) 2018-06-29 2020-01-02 Blade Therapeutics, Inc. Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof
JP2020524158A (ja) 2017-06-20 2020-08-13 山東丹紅制薬有限公司Ｓｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． Ｓｓａｏ阻害剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504485A (ja) 2007-11-21 2011-02-10 ファーマクシス リミテッド Ｓｓａｏ／ｖａｐ−１のハロアリルアミン阻害剤およびその用途
JP2015521167A (ja) 2012-05-02 2015-07-27 ファームアクシス・リミテッドＰｈａｒｍａｘｉｓ Ｌｔｄ Ｓｓａｏの置換３−ハロアリルアミン阻害剤およびその使用
JP2020524158A (ja) 2017-06-20 2020-08-13 山東丹紅制薬有限公司Ｓｈａｎｄｏｎｇ Ｄａｎｈｏｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． Ｓｓａｏ阻害剤
CN109251166A (zh) 2017-07-13 2019-01-22 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2019024924A1 (zh) 2017-08-04 2019-02-07 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2020006177A1 (en) 2018-06-29 2020-01-02 Blade Therapeutics, Inc. Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof

Also Published As

Publication number Publication date
CN115916337B (zh) 2025-04-15
US20230257342A1 (en) 2023-08-17
US12428370B2 (en) 2025-09-30
EP4171740A1 (en) 2023-05-03
EP4171740A4 (en) 2024-01-03
JP2023531468A (ja) 2023-07-24
CN115916337A (zh) 2023-04-04
WO2021258159A1 (en) 2021-12-30

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