EP4171740A4 - HALOALLYLAMIN DOUBLE AMIN OXIDASE INHIBITORS - Google Patents

HALOALLYLAMIN DOUBLE AMIN OXIDASE INHIBITORS Download PDF

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Publication number
EP4171740A4
EP4171740A4 EP21829882.6A EP21829882A EP4171740A4 EP 4171740 A4 EP4171740 A4 EP 4171740A4 EP 21829882 A EP21829882 A EP 21829882A EP 4171740 A4 EP4171740 A4 EP 4171740A4
Authority
EP
European Patent Office
Prior art keywords
haloallylamine
oxidase inhibitors
amine oxidase
dual
dual amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21829882.6A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP4171740A1 (en
Inventor
Alan Duncan Robertson
Alison Dorothy Findlay
Alberto Buson
Craig Ivan Turner
Dieter Wolfgang Hamprecht
Jonathan Stuart Foot
Mandar Deodhar
Wolfgang JAROLIMEK
Serena Becchi
Bernard Walter Balleine
Marcella Canton
Libero VITIELLO
Bert BLAAUW
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmaxis Ltd
Original Assignee
Pharmaxis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2020902152A external-priority patent/AU2020902152A0/en
Application filed by Pharmaxis Ltd filed Critical Pharmaxis Ltd
Publication of EP4171740A1 publication Critical patent/EP4171740A1/en
Publication of EP4171740A4 publication Critical patent/EP4171740A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP21829882.6A 2020-06-26 2021-06-25 HALOALLYLAMIN DOUBLE AMIN OXIDASE INHIBITORS Pending EP4171740A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2020902152A AU2020902152A0 (en) 2020-06-26 Haloallyamine dual amine oxidase inhibitors
PCT/AU2021/050675 WO2021258159A1 (en) 2020-06-26 2021-06-25 Haloallylamine dual amine oxidase inhibitors

Publications (2)

Publication Number Publication Date
EP4171740A1 EP4171740A1 (en) 2023-05-03
EP4171740A4 true EP4171740A4 (en) 2024-01-03

Family

ID=79282315

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21829882.6A Pending EP4171740A4 (en) 2020-06-26 2021-06-25 HALOALLYLAMIN DOUBLE AMIN OXIDASE INHIBITORS

Country Status (5)

Country Link
US (1) US12428370B2 (https=)
EP (1) EP4171740A4 (https=)
JP (1) JP7665122B2 (https=)
CN (1) CN115916337B (https=)
WO (1) WO2021258159A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250022712A (ko) * 2022-05-30 2025-02-17 기초과학연구원 모노아민 산화효소 b에 대한 안티센스 올리고머 및 이의 용도
AU2023331414A1 (en) * 2022-08-29 2025-03-27 Syntara Limited Novel selective inhibitors of lysyl oxidases
KR20250174618A (ko) * 2023-03-22 2025-12-12 쿠보타 비전 인코포레이티드 신경 염증의 치료

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
CN101917845A (zh) * 2007-11-21 2010-12-15 法马克西斯制药公司 Ssao/vap-1的卤代烯丙胺抑制剂及其用途
AU2013255103B2 (en) * 2012-05-02 2016-09-29 Syntara Limited Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
AU2018287777B2 (en) 2017-06-20 2020-05-21 Shandong Danhong Pharmaceutical Co., Ltd. SSAO inhibitor
CN109251166B (zh) * 2017-07-13 2021-11-05 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
WO2019024924A1 (zh) * 2017-08-04 2019-02-07 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用
US20210238192A1 (en) * 2018-06-29 2021-08-05 Blade Therapeutics, Inc. Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
CN115916337B (zh) 2025-04-15
US20230257342A1 (en) 2023-08-17
JP7665122B2 (ja) 2025-04-21
US12428370B2 (en) 2025-09-30
EP4171740A1 (en) 2023-05-03
JP2023531468A (ja) 2023-07-24
CN115916337A (zh) 2023-04-04
WO2021258159A1 (en) 2021-12-30

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