JP7659553B2 - アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト - Google Patents

アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト Download PDF

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JP7659553B2
JP7659553B2 JP2022525958A JP2022525958A JP7659553B2 JP 7659553 B2 JP7659553 B2 JP 7659553B2 JP 2022525958 A JP2022525958 A JP 2022525958A JP 2022525958 A JP2022525958 A JP 2022525958A JP 7659553 B2 JP7659553 B2 JP 7659553B2
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cancer
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JP2023513655A5 (https=
JP2023513655A (ja
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コスフォード，ニコラス，デイビッド，ピーター
ハイマン，ドミニク
テリーテ，ピーター
クマール チャンダー，スミト
パシュ，ラーズ
バタ，ニコル
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サンフォード バーンハム プレビス メディカル ディスカバリー インスティテュート
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/20—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022525958A 2019-11-08 2020-11-06 アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト Active JP7659553B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025054317A JP2025118594A (ja) 2019-11-08 2025-03-27 アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962933190P 2019-11-08 2019-11-08
US62/933,190 2019-11-08
PCT/US2020/059552 WO2021092500A1 (en) 2019-11-08 2020-11-06 Inhibitor of apoptosis (iap) protein antagonists

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JP2025054317A Division JP2025118594A (ja) 2019-11-08 2025-03-27 アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト

Publications (3)

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JP2023513655A JP2023513655A (ja) 2023-04-03
JP2023513655A5 JP2023513655A5 (https=) 2023-10-18
JP7659553B2 true JP7659553B2 (ja) 2025-04-09

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JP2022525958A Active JP7659553B2 (ja) 2019-11-08 2020-11-06 アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト
JP2025054317A Pending JP2025118594A (ja) 2019-11-08 2025-03-27 アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト

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Country Status (6)

Country Link
US (1) US20230115837A1 (https=)
EP (1) EP4058454A4 (https=)
JP (2) JP7659553B2 (https=)
AU (1) AU2020380818A1 (https=)
CA (1) CA3160666A1 (https=)
WO (1) WO2021092500A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025118594A (ja) * 2019-11-08 2025-08-13 サンフォード バーンハム プレビス メディカル ディスカバリー インスティテュート アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020110056A1 (en) * 2018-11-30 2020-06-04 Glaxosmithkline Intellectual Property Development Limited Compounds useful in hiv therapy
AU2021265826B2 (en) * 2020-04-30 2026-03-19 Sanford Burnham Prebys Medical Discovery Institute Inhibitor of apoptosis (IAP) protein antagonists
CN117304253A (zh) * 2022-06-22 2023-12-29 中国药科大学 一种二氮杂双环拟肽衍生物的制备方法及应用

Citations (6)

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Publication number Priority date Publication date Assignee Title
JP2009536204A (ja) 2006-05-05 2009-10-08 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 二価ｓｍａｃ模倣物およびその使用
JP2012529482A (ja) 2009-06-12 2012-11-22 アストラゼネカ アクチボラグ ２，３−ジヒドロ−１ｈ−インデン化合物および癌を治療するためのその使用
JP2013509429A (ja) 2009-10-28 2013-03-14 ジョイアント ファーマスーティカルズ、インク． 二量体Ｓｍａｃ模倣薬
JP2016501223A (ja) 2012-11-30 2016-01-18 サンフォード−バーンハム メディカル リサーチ インスティテュート アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト
JP2017522273A (ja) 2014-06-04 2017-08-10 サンフォード−バーンハム メディカル リサーチ インスティテュート Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用
JP2022509869A (ja) 2018-11-30 2022-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｈｉｖ療法に有用な化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
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US8202902B2 (en) * 2006-05-05 2012-06-19 The Regents Of The University Of Michigan Bivalent SMAC mimetics and the uses thereof
KR20180107261A (ko) * 2016-02-16 2018-10-01 메사추세츠 인스티튜트 오브 테크놀로지 Myc 조정제로서의 MAX 결합제 및 그의 용도
US10870663B2 (en) * 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
CA3160666A1 (en) * 2019-11-08 2021-05-14 Sanford Burnham Prebys Medical Discovery Institute Inhibitor of apoptosis (iap) protein antagonists

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009536204A (ja) 2006-05-05 2009-10-08 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 二価ｓｍａｃ模倣物およびその使用
JP2012529482A (ja) 2009-06-12 2012-11-22 アストラゼネカ アクチボラグ ２，３−ジヒドロ−１ｈ−インデン化合物および癌を治療するためのその使用
JP2013509429A (ja) 2009-10-28 2013-03-14 ジョイアント ファーマスーティカルズ、インク． 二量体Ｓｍａｃ模倣薬
JP2016501223A (ja) 2012-11-30 2016-01-18 サンフォード−バーンハム メディカル リサーチ インスティテュート アポトーシス阻害タンパク質（ｉａｐ）のアンタゴニスト
JP2017522273A (ja) 2014-06-04 2017-08-10 サンフォード−バーンハム メディカル リサーチ インスティテュート Ｈｉｖ治療におけるアポトーシスタンパク質阻害剤（ｉａｐ）のアンタゴニストの使用
JP2022509869A (ja) 2018-11-30 2022-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｈｉｖ療法に有用な化合物

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Title
Haiying Sun, Liu Liu, Jianfeng Lu, Longchuan Bai, Xiaoqin Li, Zaneta Nikolovska-Coleska, Donna McEachern, Chao-Yie Yang, Su Qiu, Han Yi, Duxin Sun and Shaomeng Wang，Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity，Journal of Medicinal Chemistry，米国，American Chemical Society，2011年04月04日，54(9)，3306-3318
Jianfeng Lu, Longchuan Bai, Haiying Sun, Zaneta Nikolovska-Coleska, Donna McEachern, Su Qiu, Rebecca S. Miller, Han Yi, Sanjeev Shangary, Yi Sun, Jennifer L. Meagher, Jeanne A. Stuckey, and Shaomeng Wang，SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP，Cancer Research，米国，American Association for Cancer Research，2008年11月15日，68(22)，9384-9393
MITCHELL VAMOS; ET AL，EXPEDIENT SYNTHESIS OF HIGHLY POTENT ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS (IAPS) WITH UNIQ，ACS CHEMICAL BIOLOGY，2013年04月19日，VOL:8, NR:4，PAGE(S):725-732，https://doi.org/10.1021/cb3005512

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025118594A (ja) * 2019-11-08 2025-08-13 サンフォード バーンハム プレビス メディカル ディスカバリー インスティテュート アポトーシス阻害（ｉａｐ）タンパク質アンタゴニスト

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CA3160666A1 (en) 2021-05-14
JP2023513655A (ja) 2023-04-03
AU2020380818A1 (en) 2022-06-02
JP2025118594A (ja) 2025-08-13
EP4058454A4 (en) 2023-12-13
WO2021092500A1 (en) 2021-05-14
US20230115837A1 (en) 2023-04-13
EP4058454A1 (en) 2022-09-21

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