JP7649962B2 - 葉酸塩製剤 - Google Patents
葉酸塩製剤 Download PDFInfo
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- JP7649962B2 JP7649962B2 JP2021510406A JP2021510406A JP7649962B2 JP 7649962 B2 JP7649962 B2 JP 7649962B2 JP 2021510406 A JP2021510406 A JP 2021510406A JP 2021510406 A JP2021510406 A JP 2021510406A JP 7649962 B2 JP7649962 B2 JP 7649962B2
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title claims description 133
- 235000019152 folic acid Nutrition 0.000 title claims description 83
- 239000011724 folic acid Substances 0.000 title claims description 80
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- 238000002360 preparation method Methods 0.000 title claims description 5
- 239000000203 mixture Substances 0.000 claims description 79
- 238000009472 formulation Methods 0.000 claims description 72
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 53
- 229960000304 folic acid Drugs 0.000 claims description 53
- 230000002829 reductive effect Effects 0.000 claims description 33
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 31
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 27
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- 230000004410 intraocular pressure Effects 0.000 claims description 25
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 24
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 20
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- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 17
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 17
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- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims description 14
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 12
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 12
- 235000019192 riboflavin Nutrition 0.000 claims description 12
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- 229910052711 selenium Inorganic materials 0.000 claims description 12
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- 229940091258 selenium supplement Drugs 0.000 claims description 12
- 150000003464 sulfur compounds Chemical class 0.000 claims description 12
- ZNOVTXRBGFNYRX-STQMWFEESA-N (6S)-5-methyltetrahydrofolic acid Chemical compound C([C@@H]1N(C=2C(=O)N=C(N)NC=2NC1)C)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-STQMWFEESA-N 0.000 claims description 11
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 11
- VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 claims description 10
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 10
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 10
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 10
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- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 9
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- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 8
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- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 8
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- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims description 8
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- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 6
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18191572.9 | 2018-08-29 | ||
| EP18191572.9A EP3616700A1 (en) | 2018-08-29 | 2018-08-29 | Folate preparations for use in the treatment of eye diseases |
| PCT/EP2019/073118 WO2020043840A1 (en) | 2018-08-29 | 2019-08-29 | Folate preparations |
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| JP2021535131A JP2021535131A (ja) | 2021-12-16 |
| JP2021535131A5 JP2021535131A5 (https=) | 2022-10-24 |
| JP7649962B2 true JP7649962B2 (ja) | 2025-03-24 |
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| JP2021510406A Active JP7649962B2 (ja) | 2018-08-29 | 2019-08-29 | 葉酸塩製剤 |
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| JP (1) | JP7649962B2 (https=) |
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| CA (1) | CA3110285A1 (https=) |
| WO (1) | WO2020043840A1 (https=) |
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| EP3461826A1 (en) * | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
| EP3646873A1 (en) * | 2018-10-31 | 2020-05-06 | Aprofol AG | Folate salts |
| EP3875094A1 (en) * | 2020-03-02 | 2021-09-08 | Aprofol AG | Folate preparations for the treatment of ocular diseases |
| CN117561065A (zh) * | 2021-06-24 | 2024-02-13 | 连云港金康和信药业有限公司 | 叶酸类衍生物在制备治疗隐形眼镜不适及干眼症药物的应用 |
| GB202302379D0 (en) * | 2023-02-20 | 2023-04-05 | Upl Mauritius Ltd | Agrochemical composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080113900A1 (en) | 2006-09-22 | 2008-05-15 | Brasch Nicola E | Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin |
| US20110319356A1 (en) | 2010-06-25 | 2011-12-29 | Buell Brian W | Methods Of Treating Optic Disorders |
| JP2013544275A (ja) | 2010-12-03 | 2013-12-12 | ラオフ・レキク | 葉酸−ラミプリルの組合せ：細胞保護性、神経保護性、および網膜保護性の眼科用組成物 |
| WO2014177274A1 (en) | 2013-04-30 | 2014-11-06 | Aprofol Ag | Stable pharmaceutical composition containing folates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103756A (en) * | 1999-08-11 | 2000-08-15 | Vitacost Inc. | Ocular orally ingested composition for prevention and treatment of individuals |
| US20040087479A1 (en) * | 2001-04-30 | 2004-05-06 | Sosnowski Robert E. | Composition and method for reducing the risk or progression of cardiovascular, glaucoma, tardive dyskinesia and other diseases |
| EP1962618A2 (en) * | 2005-12-20 | 2008-09-03 | Alcon Research, Ltd. | Composition and methods for inhibiting the progression macular degeneration and promoting healthy vision |
| DE202015105351U1 (de) * | 2015-10-09 | 2016-01-07 | Apotheke am Schlossplatz Inh. Mario Ganster e.K. | Diätetische Zusammensetzung |
-
2018
- 2018-08-29 EP EP18191572.9A patent/EP3616700A1/en not_active Withdrawn
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2019
- 2019-08-29 CA CA3110285A patent/CA3110285A1/en active Pending
- 2019-08-29 US US17/271,468 patent/US12048702B2/en active Active
- 2019-08-29 JP JP2021510406A patent/JP7649962B2/ja active Active
- 2019-08-29 EP EP19759594.5A patent/EP3843744A1/en active Pending
- 2019-08-29 AU AU2019331652A patent/AU2019331652B2/en active Active
- 2019-08-29 WO PCT/EP2019/073118 patent/WO2020043840A1/en not_active Ceased
- 2019-08-29 CN CN201980056865.0A patent/CN112672745A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080113900A1 (en) | 2006-09-22 | 2008-05-15 | Brasch Nicola E | Pharmaceutical compositions and therapeutic applications for the use of a synthetic vitamin B12 derivative, glutathionylcobalamin |
| US20110319356A1 (en) | 2010-06-25 | 2011-12-29 | Buell Brian W | Methods Of Treating Optic Disorders |
| JP2013544275A (ja) | 2010-12-03 | 2013-12-12 | ラオフ・レキク | 葉酸−ラミプリルの組合せ：細胞保護性、神経保護性、および網膜保護性の眼科用組成物 |
| WO2014177274A1 (en) | 2013-04-30 | 2014-11-06 | Aprofol Ag | Stable pharmaceutical composition containing folates |
Non-Patent Citations (4)
| Title |
|---|
| Clinical Interventions in Aging，2010年，Vol. 5，pp. 133-139 |
| International Medical Case Reports Journal，2016年，Vol.9，pp.29-34 |
| JAMA OPHTHALMOLOGY，2014年04月30日，VOL:132, NR:5，PAGE(S):549-559，https://doi.org/10.1001/jamaophthalmol.2014.100 |
| XENOBIOTICA，2014年05月31日，VOL:44, NR:5，PAGE(S):1-9(480-488)，https://doi.org/10.3109/00498254.2013.845705 |
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| AU2019331652A1 (en) | 2021-03-18 |
| AU2019331652B2 (en) | 2025-01-23 |
| US20210308139A1 (en) | 2021-10-07 |
| US12048702B2 (en) | 2024-07-30 |
| WO2020043840A1 (en) | 2020-03-05 |
| EP3616700A1 (en) | 2020-03-04 |
| CA3110285A1 (en) | 2020-03-05 |
| EP3843744A1 (en) | 2021-07-07 |
| JP2021535131A (ja) | 2021-12-16 |
| CN112672745A (zh) | 2021-04-16 |
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