JP7646119B2 - ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 - Google Patents

３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 Download PDF

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JP7646119B2
JP7646119B2 JP2020546516A JP2020546516A JP7646119B2 JP 7646119 B2 JP7646119 B2 JP 7646119B2 JP 2020546516 A JP2020546516 A JP 2020546516A JP 2020546516 A JP2020546516 A JP 2020546516A JP 7646119 B2 JP7646119 B2 JP 7646119B2
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coa
acid
pbbr1mcs
reaction
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匡平 磯部
健司 河村
勝成 山田
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Toray Industries Inc
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01035—3-Hydroxyacyl-CoA dehydrogenase (1.1.1.35)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01049—Phosphoenolpyruvate carboxykinase (ATP) (4.1.1.49)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/425—Serratia

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  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2020546516A 2019-05-10 2020-05-08 ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法 Active JP7646119B2 (ja)

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JP2019089771 2019-05-10
JP2019089771 2019-05-10
PCT/JP2020/018665 WO2020230719A1 (ja) 2019-05-10 2020-05-08 ３－ヒドロキシアジピン酸、α－ヒドロムコン酸および／またはアジピン酸を生産するための遺伝子改変微生物および当該化学品の製造方法

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JPWO2020230719A1 JPWO2020230719A1 (https=) 2020-11-19
JPWO2020230719A5 JPWO2020230719A5 (https=) 2023-05-08
JP7646119B2 true JP7646119B2 (ja) 2025-03-17

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US (1) US20220228178A1 (https=)
EP (1) EP3967763A4 (https=)
JP (1) JP7646119B2 (https=)
CN (1) CN113795589A (https=)
BR (1) BR112021021601A2 (https=)
WO (1) WO2020230719A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12275979B2 (en) * 2017-11-30 2025-04-15 Toray Industries, Inc. Gene-modified microorganism for producing 3-hydroxyadipic acid, alpha-hydromuconic acid, and/or adipic acid, and production method for said chemical products
US20230392112A1 (en) * 2020-11-11 2023-12-07 Toray Industries, Inc. Genetically modified microorganism for producing 3-hydroxyadipic acid and/or alpha-hydromuconic acid, and method for producing chemical product
US20250382643A1 (en) 2022-02-15 2025-12-18 Toray Industries, Inc. GENETICALLY MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID AND/OR Alpha-HYDROXYADIPIC ACID, AND METHOD FOR PRODUCING CHEMICAL PRODUCT

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO2009151728A2 (en) 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
WO2016199856A1 (ja) 2015-06-10 2016-12-15 東レ株式会社 ３－ヒドロキシアジピン酸の製造方法
WO2016199858A1 (ja) 2015-06-10 2016-12-15 東レ株式会社 α－ヒドロムコン酸の製造方法
WO2017209103A1 (ja) 2016-05-31 2017-12-07 東レ株式会社 α－ヒドロムコン酸の製造方法
WO2017209102A1 (ja) 2016-05-31 2017-12-07 東レ株式会社 ３－ヒドロキシアジピン酸の製造方法

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KR100630836B1 (ko) 2005-04-08 2006-10-02 한국과학기술원 인-실리코 분석을 통한 균주 개량방법
DK2427544T3 (da) 2009-05-07 2019-10-07 Genomatica Inc Mikroorganismer og fremgangsmåder til biosyntese af adipat, hexamethylendiamin og 6-aminokapronsyre
WO2011017560A1 (en) 2009-08-05 2011-02-10 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
BR112013001635A2 (pt) 2010-07-26 2016-05-24 Genomatica Inc micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno
ES2663445T3 (es) 2012-01-30 2018-04-12 Myriant Corporation Producción de ácido mucónico a partir de microorganismos modificados genéticamente
TWI716752B (zh) * 2012-12-17 2021-01-21 美商奇諾麥提卡公司 用於增加甲醇存在下之還原當量可利用性及用於製造與其相關己二酸、6-胺基己酸、己二胺或己內醯胺之微生物及方法
EP3741865B1 (en) * 2014-09-18 2024-03-13 Genomatica, Inc. Non-natural microbial organisms with improved energetic efficiency
JP7127987B2 (ja) * 2014-12-23 2022-08-30 ジェノマティカ， インコーポレイテッド ジアミンの製造および処理方法
EP3388525B1 (en) 2015-12-11 2020-09-16 Toray Industries, Inc. Method for producing 3-oxoadipic acid by fermentation
KR20190026851A (ko) * 2016-07-08 2019-03-13 에보니크 데구사 게엠베하 당 포스포트랜스퍼라제 시스템 (pts)을 코딩하는 유전자를 포함하는 미생물에 의한 메티오닌 또는 그의 히드록시 유사체 형태의 발효적 생산을 위한 방법
US12275979B2 (en) * 2017-11-30 2025-04-15 Toray Industries, Inc. Gene-modified microorganism for producing 3-hydroxyadipic acid, alpha-hydromuconic acid, and/or adipic acid, and production method for said chemical products

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Publication number Priority date Publication date Assignee Title
WO2009151728A2 (en) 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
WO2016199856A1 (ja) 2015-06-10 2016-12-15 東レ株式会社 ３－ヒドロキシアジピン酸の製造方法
WO2016199858A1 (ja) 2015-06-10 2016-12-15 東レ株式会社 α－ヒドロムコン酸の製造方法
WO2017209103A1 (ja) 2016-05-31 2017-12-07 東レ株式会社 α－ヒドロムコン酸の製造方法
WO2017209102A1 (ja) 2016-05-31 2017-12-07 東レ株式会社 ３－ヒドロキシアジピン酸の製造方法

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"3-hydroxybutyryl-CoA dehydrogenase [Serratia liquwfaciens]."，[online]，Database GenBank，2016年02月11日，Accession No. AMG98270.1，インターネット <URL: https://www.ncbi. nlm.gov/protein/991935067?sat=4&satkey=158110186>，[検索日 2019.02.06]
"3-hydroxybutyryl-CoA dehydrogenase [Serratia marcescens]."，[online]，Database GenBank，2017年02月28日，Accession No. ALL37524.1，インターネット <URL: https://www.ncbi.nlm.nih.gov/protein/943365850>，[検索日 2019.02.06]
"3-hydroxybutyryl-CoA dehydrogenase [Serratia marcescens]."，[online]，Database GenBank，2017年07月18日，Accession No. ASM11476.1，インターネット <URL: https://www.ncbi.nlm.gov/protein/ASM11476.1>，[検索日 2019.02.06]
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EP3967763A4 (en) 2024-01-03
US20220228178A1 (en) 2022-07-21
WO2020230719A1 (ja) 2020-11-19
JPWO2020230719A1 (https=) 2020-11-19
EP3967763A1 (en) 2022-03-16
BR112021021601A2 (pt) 2021-12-21
CN113795589A (zh) 2021-12-14

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