JP7636654B2 - アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 - Google Patents
アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 Download PDFInfo
- Publication number
- JP7636654B2 JP7636654B2 JP2020175649A JP2020175649A JP7636654B2 JP 7636654 B2 JP7636654 B2 JP 7636654B2 JP 2020175649 A JP2020175649 A JP 2020175649A JP 2020175649 A JP2020175649 A JP 2020175649A JP 7636654 B2 JP7636654 B2 JP 7636654B2
- Authority
- JP
- Japan
- Prior art keywords
- phagocytosis
- inhibitor
- epidermal keratinocytes
- fibroblasts
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010057249 Phagocytosis Diseases 0.000 title claims description 112
- 230000008782 phagocytosis Effects 0.000 title claims description 112
- 239000003112 inhibitor Substances 0.000 title claims description 83
- 230000015572 biosynthetic process Effects 0.000 title claims description 27
- 238000002360 preparation method Methods 0.000 title claims description 23
- 102000007469 Actins Human genes 0.000 title description 67
- 108010085238 Actins Proteins 0.000 title description 67
- 230000008521 reorganization Effects 0.000 title description 59
- 230000019612 pigmentation Effects 0.000 title description 13
- 210000005175 epidermal keratinocyte Anatomy 0.000 claims description 156
- 210000002950 fibroblast Anatomy 0.000 claims description 112
- 239000003636 conditioned culture medium Substances 0.000 claims description 110
- 239000000284 extract Substances 0.000 claims description 93
- 230000002401 inhibitory effect Effects 0.000 claims description 46
- 235000006468 Thea sinensis Nutrition 0.000 claims description 41
- 244000269722 Thea sinensis Species 0.000 claims description 34
- 235000018597 common camellia Nutrition 0.000 claims description 27
- 210000003491 skin Anatomy 0.000 claims description 22
- 235000020279 black tea Nutrition 0.000 claims description 16
- 235000020333 oolong tea Nutrition 0.000 claims description 16
- 239000004480 active ingredient Substances 0.000 claims description 13
- 235000020688 green tea extract Nutrition 0.000 claims description 13
- 229940094952 green tea extract Drugs 0.000 claims description 13
- 239000000419 plant extract Substances 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 9
- 241000209507 Camellia Species 0.000 claims 3
- 238000012360 testing method Methods 0.000 description 124
- 239000000126 substance Substances 0.000 description 81
- 210000004027 cell Anatomy 0.000 description 58
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 34
- 239000002609 medium Substances 0.000 description 33
- 240000001548 Camellia japonica Species 0.000 description 27
- 238000004519 manufacturing process Methods 0.000 description 27
- 238000000605 extraction Methods 0.000 description 22
- 230000006698 induction Effects 0.000 description 21
- 239000011324 bead Substances 0.000 description 18
- 239000011859 microparticle Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 14
- 239000002994 raw material Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 208000012641 Pigmentation disease Diseases 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 210000002780 melanosome Anatomy 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 210000004694 pigment cell Anatomy 0.000 description 11
- 238000012216 screening Methods 0.000 description 11
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 238000010998 test method Methods 0.000 description 10
- 206010024217 lentigo Diseases 0.000 description 8
- 241000282412 Homo Species 0.000 description 7
- 238000012258 culturing Methods 0.000 description 7
- 230000015286 negative regulation of phagocytosis Effects 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- 235000013616 tea Nutrition 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- -1 suppressor Substances 0.000 description 6
- 244000060696 Alpinia speciosa Species 0.000 description 5
- 235000013411 Alpinia speciosa Nutrition 0.000 description 5
- 241000209205 Coix Species 0.000 description 5
- 235000007354 Coix lacryma jobi Nutrition 0.000 description 5
- 229960000271 arbutin Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 5
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 5
- 229960004705 kojic acid Drugs 0.000 description 5
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 5
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- 238000000692 Student's t-test Methods 0.000 description 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- SDZRWUKZFQQKKV-JHADDHBZSA-N cytochalasin D Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@H]\3[C@]2([C@@H](/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/3)OC(C)=O)C(=O)N1)=C)C)C1=CC=CC=C1 SDZRWUKZFQQKKV-JHADDHBZSA-N 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 108700038288 rhodamine-phalloidin Proteins 0.000 description 4
- 238000012353 t test Methods 0.000 description 4
- 238000012795 verification Methods 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 235000006467 Camellia japonica Nutrition 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000195480 Fucus Species 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 229940118127 fucus vesiculosus extract Drugs 0.000 description 3
- 235000009569 green tea Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000003061 melanogenesis Effects 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- YJIYWYAMZFVECX-UHFFFAOYSA-N 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=CC=C1OCCOC1=CC=CC=C1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O YJIYWYAMZFVECX-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000062730 Melissa officinalis Species 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000002469 basement membrane Anatomy 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000019225 fermented tea Nutrition 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000008099 melanin synthesis Effects 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- INAAIJLSXJJHOZ-UHFFFAOYSA-N pibenzimol Chemical compound C1CN(C)CCN1C1=CC=C(N=C(N2)C=3C=C4NC(=NC4=CC=3)C=3C=CC(O)=CC=3)C2=C1 INAAIJLSXJJHOZ-UHFFFAOYSA-N 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 230000008707 rearrangement Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 229940122937 Actin inhibitor Drugs 0.000 description 1
- 241000013298 Alpinia <beetle> Species 0.000 description 1
- 244000077995 Coix lacryma jobi Species 0.000 description 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 102400000686 Endothelin-1 Human genes 0.000 description 1
- 101800004490 Endothelin-1 Proteins 0.000 description 1
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 1
- 101001036711 Gallus gallus Heat shock protein beta-1 Proteins 0.000 description 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241000134253 Lanka Species 0.000 description 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000042463 Rho family Human genes 0.000 description 1
- 108091078243 Rho family Proteins 0.000 description 1
- 206010064127 Solar lentigo Diseases 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 102000008230 Toll-like receptor 3 Human genes 0.000 description 1
- 108010060885 Toll-like receptor 3 Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 231100000764 actin inhibitor Toxicity 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- WHLPIOPUASGRQN-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C WHLPIOPUASGRQN-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 238000002991 immunohistochemical analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 108010029560 keratinocyte growth factor receptor Proteins 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000037316 sun-exposed skin Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020175649A JP7636654B2 (ja) | 2020-09-30 | 2020-09-30 | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020175649A JP7636654B2 (ja) | 2020-09-30 | 2020-09-30 | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022058063A JP2022058063A (ja) | 2022-04-11 |
| JP2022058063A5 JP2022058063A5 (enExample) | 2023-12-18 |
| JP7636654B2 true JP7636654B2 (ja) | 2025-02-27 |
Family
ID=81111329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020175649A Active JP7636654B2 (ja) | 2020-09-30 | 2020-09-30 | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7636654B2 (enExample) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002519312A (ja) | 1998-06-30 | 2002-07-02 | エイボン プロダクツ インコーポレーテッド | 皮膚美白組成物 |
| US20030175234A1 (en) | 2002-02-22 | 2003-09-18 | Steven Hernandez | Use of polyphenols to treat skin conditions |
| JP2012102049A (ja) | 2010-11-10 | 2012-05-31 | Nof Corp | 表皮角化細胞賦活剤および皮膚外用剤 |
| US20120156150A1 (en) | 2010-12-17 | 2012-06-21 | Keimyung University Industry Academic Cooperation Foundation | Composition for Improving Skin Condition Comprising Extract from Black Tea as Active Ingredient |
| CN109833276A (zh) | 2019-04-01 | 2019-06-04 | 合肥卡迪尔生物科技有限公司 | 一种美白面膜及其制备方法 |
| JP2020110143A (ja) | 2019-01-15 | 2020-07-27 | アモーレパシフィック コーポレーションAmorepacific Corporation | 成分含量が変化した緑茶抽出物を含む皮膚美白用又は皮膚しわ予防又は改善用組成物 |
-
2020
- 2020-09-30 JP JP2020175649A patent/JP7636654B2/ja active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002519312A (ja) | 1998-06-30 | 2002-07-02 | エイボン プロダクツ インコーポレーテッド | 皮膚美白組成物 |
| US20030175234A1 (en) | 2002-02-22 | 2003-09-18 | Steven Hernandez | Use of polyphenols to treat skin conditions |
| JP2012102049A (ja) | 2010-11-10 | 2012-05-31 | Nof Corp | 表皮角化細胞賦活剤および皮膚外用剤 |
| US20120156150A1 (en) | 2010-12-17 | 2012-06-21 | Keimyung University Industry Academic Cooperation Foundation | Composition for Improving Skin Condition Comprising Extract from Black Tea as Active Ingredient |
| JP2020110143A (ja) | 2019-01-15 | 2020-07-27 | アモーレパシフィック コーポレーションAmorepacific Corporation | 成分含量が変化した緑茶抽出物を含む皮膚美白用又は皮膚しわ予防又は改善用組成物 |
| CN109833276A (zh) | 2019-04-01 | 2019-06-04 | 合肥卡迪尔生物科技有限公司 | 一种美白面膜及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022058063A (ja) | 2022-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3005605C (en) | Topical composition comprising a small rna tiger lily extract and method of cosmetic care to reduce skin signs of aging | |
| JP2025094269A (ja) | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 | |
| KR20120028238A (ko) | 덴드로븀 크리소톡숨 추출물 및 항노화제로서 이의 화장품학적 용도 | |
| Leis Ayres et al. | Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin‐1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation | |
| US8268366B2 (en) | Cosmetic composition containing salt-fermented extract of natural materials | |
| JP6065289B2 (ja) | 抽出方法、美白化粧品を生産する方法及びヘアケア製品を生産する方法 | |
| KR102505275B1 (ko) | 인진쑥 추출물 또는 인진쑥 발효물을 유효성분으로 포함하는 탈모 예방, 개선 또는 방지용 화장료 조성물 | |
| EP2246037A2 (en) | Anti-aging and whitening properties of quercetin, 18a-glycyrrhetinic acid, hederagenin and its derivatives | |
| EP2762131A1 (en) | Use of Salvia Haenkei extracts in compositions for antisenescence | |
| KR20140018666A (ko) | 발효콩 추출물을 함유하는 피부 외용제 조성물 | |
| US8986758B2 (en) | Method for extracting a traditional herbal medicine component using a polished-rice steaming method | |
| KR101813871B1 (ko) | 피부에 대한 주름개선 및 항염증 기능을 갖는 복합 한약재 추출물 함유 화장료 조성물 및 그 제조 방법 | |
| JP7680661B2 (ja) | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 | |
| JP2022058063A (ja) | アクチン再編成阻害剤、ファゴサイトーシス阻害剤、該阻害剤を含有するシミ形成抑制剤、並びに該抑制剤を含有する皮膚外用剤 | |
| KR100762287B1 (ko) | 해양 심층수와 복숭아꽃 추출물을 함유하는 고미네랄 화장료 조성물 | |
| US9668961B2 (en) | Screening method and substances for contrasting aging | |
| KR20150085991A (ko) | 한방 약재성분의 복합추출물이 함유된 피부미백용 화장료 조성물 | |
| KR102106813B1 (ko) | 양파 추출물을 포함하는 피부 손상 예방 및 피부 재생 촉진용 조성물 및 그 제조방법 | |
| KR20030086933A (ko) | 잘피 추출물을 주요 활성성분으로 하는 화장료 조성물 | |
| KR102789270B1 (ko) | 베르게닌 함량이 증강된 예덕나무 및 코나루스 세미데칸드러스의 프로바이오틱스 발효물을 함유하는 피부톤 개선 및 에너지 부스팅 화장료 조성물 | |
| KR102869177B1 (ko) | 해당화 유래 엑소좀을 유효성분으로 포함하는 피부상태 개선용 조성물 | |
| JP2021092534A (ja) | 抗老化成分のスクリーニング方法 | |
| CN118852358B (zh) | 一种促进皮肤微生态平衡的活性肽的制备方法 | |
| CN115715750B (zh) | 一种桂花提取物及其制备方法和护肤应用 | |
| TWI830382B (zh) | 秋姬李發酵物、其製作方法和其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201016 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20230831 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20231024 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20240717 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20240910 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20241018 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20250114 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20250123 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7636654 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |