JP7636334B2 - 治療物質の眼投与のための薬物送達組成物及びその使用法 - Google Patents

治療物質の眼投与のための薬物送達組成物及びその使用法 Download PDF

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JP7636334B2
JP7636334B2 JP2021546362A JP2021546362A JP7636334B2 JP 7636334 B2 JP7636334 B2 JP 7636334B2 JP 2021546362 A JP2021546362 A JP 2021546362A JP 2021546362 A JP2021546362 A JP 2021546362A JP 7636334 B2 JP7636334 B2 JP 7636334B2
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capsules
drug delivery
agents
bevacizumab
vegf
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JPWO2020163871A5 (enExample
JP2022520183A (ja
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ジャン，ポンフェイ
エリザベス ライリー，ケイトリン
ピー オー，マシュー
ラヌッティ，ジョン
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オハイオ・ステイト・イノベーション・ファウンデーション
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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JP2021546362A 2019-02-08 2020-02-10 治療物質の眼投与のための薬物送達組成物及びその使用法 Active JP7636334B2 (ja)

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021262645A1 (en) * 2020-06-22 2021-12-30 Ohio State Innovation Foundation Redox-responsive nanoparticle compositions for ocular delivery of therapeutics
EP4230226A4 (en) * 2020-10-13 2024-09-11 The Asan Foundation Composition for treating retinal or choroidal diseases, containing acta2 inhibitor as active ingredient
US20240197637A1 (en) 2021-04-16 2024-06-20 Fondazione Istituto Italiano Di Tecnologia Polymeric microparticles for the local treatment of chronic inflammatory diseases
EP4358944A4 (en) * 2021-06-21 2025-03-12 William Marsh Rice University HIGH-YIELD PREPARATION OF PULSATILE-RELEASE MICROPARTICLES
CN113737393B (zh) * 2021-09-15 2022-06-07 陕西环保产业研究院有限公司 一种静电纺丝纳米纤维膜及其制备方法
CN120478308B (zh) * 2025-07-17 2025-09-09 乐比(广州)健康产业有限公司 一种基于天然提取物的护眼组合物及其制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516522A (en) * 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US7838037B2 (en) * 1999-11-17 2010-11-23 Tagra Biotechnologies Ltd. Method of microencapsulation
US20080102114A1 (en) * 2004-04-23 2008-05-01 Panduranga Rao Koritala Microparticles and Nanoparticles for the Transmucosal Delivery of Therapeutic and Diagnostic Agents
CN101137370B (zh) * 2005-02-09 2014-08-13 参天制药株式会社 用于治疗疾病或病症的液体制剂
US20110038939A1 (en) * 2007-07-16 2011-02-17 Northeastern University Therapeutic stable nanoparticles
EP2560576B1 (en) * 2010-04-22 2018-07-18 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US9636309B2 (en) * 2010-09-09 2017-05-02 Micell Technologies, Inc. Macrolide dosage forms
CA2865132A1 (en) * 2012-02-22 2013-08-29 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
EP3078384A1 (en) * 2012-02-22 2016-10-12 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions
JP2015510818A (ja) * 2012-03-20 2015-04-13 トラスティーズ オブ タフツ カレッジ 薬物送達のための絹リザーバー
US20170080030A1 (en) * 2014-03-17 2017-03-23 University Of Virginia Patent Foundation Compositions and methods for treating retinopathy

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jiang, P，Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration [Master's thesis, Ohio State University]，OhioLINK Electronic Theses and Dissertations Center，2018年，http://rave.ohiolink.edu/etdc/view?acc_num=osu1523875289847083

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