JP7616665B2 - 誘導平滑筋細胞を得るための方法 - Google Patents

誘導平滑筋細胞を得るための方法 Download PDF

Info

Publication number
JP7616665B2
JP7616665B2 JP2021552231A JP2021552231A JP7616665B2 JP 7616665 B2 JP7616665 B2 JP 7616665B2 JP 2021552231 A JP2021552231 A JP 2021552231A JP 2021552231 A JP2021552231 A JP 2021552231A JP 7616665 B2 JP7616665 B2 JP 7616665B2
Authority
JP
Japan
Prior art keywords
cells
ismcs
smooth muscle
cell
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021552231A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022526229A5 (https=
JP2022526229A (ja
Inventor
トーナー，マルコ
マークシュタイナー，ライナー
Original Assignee
インノヴァセル ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インノヴァセル ゲーエムベーハー filed Critical インノヴァセル ゲーエムベーハー
Publication of JP2022526229A publication Critical patent/JP2022526229A/ja
Publication of JP2022526229A5 publication Critical patent/JP2022526229A5/ja
Priority to JP2024179303A priority Critical patent/JP2025011242A/ja
Application granted granted Critical
Publication of JP7616665B2 publication Critical patent/JP7616665B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1323—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from skeletal muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2021552231A 2019-03-22 2020-03-23 誘導平滑筋細胞を得るための方法 Active JP7616665B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024179303A JP2025011242A (ja) 2019-03-22 2024-10-11 誘導平滑筋細胞を得るための方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19164574.6 2019-03-22
EP19164574 2019-03-22
PCT/EP2020/057940 WO2020193460A1 (en) 2019-03-22 2020-03-23 Methods for obtaining induced smooth muscle cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024179303A Division JP2025011242A (ja) 2019-03-22 2024-10-11 誘導平滑筋細胞を得るための方法

Publications (3)

Publication Number Publication Date
JP2022526229A JP2022526229A (ja) 2022-05-24
JP2022526229A5 JP2022526229A5 (https=) 2023-03-03
JP7616665B2 true JP7616665B2 (ja) 2025-01-17

Family

ID=65904308

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021552231A Active JP7616665B2 (ja) 2019-03-22 2020-03-23 誘導平滑筋細胞を得るための方法
JP2024179303A Pending JP2025011242A (ja) 2019-03-22 2024-10-11 誘導平滑筋細胞を得るための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024179303A Pending JP2025011242A (ja) 2019-03-22 2024-10-11 誘導平滑筋細胞を得るための方法

Country Status (14)

Country Link
US (2) US12312600B2 (https=)
EP (2) EP3942020B1 (https=)
JP (2) JP7616665B2 (https=)
KR (1) KR20220002315A (https=)
CN (2) CN113614223B (https=)
AU (1) AU2020247211B2 (https=)
BR (1) BR112021016264A2 (https=)
CL (1) CL2021002169A1 (https=)
DK (1) DK3942020T3 (https=)
ES (1) ES2987152T3 (https=)
IL (1) IL286509B1 (https=)
MX (1) MX2021009862A (https=)
WO (1) WO2020193460A1 (https=)
ZA (1) ZA202104948B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
US20250114405A1 (en) 2021-08-06 2025-04-10 Innovacell Gmbh Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001103963A (ja) 1999-08-19 2001-04-17 Zen Bio Inc 脂肪組織由来の間質細胞に関する多様な中胚葉系統分化能およびその使用
WO2003027281A2 (en) 2001-09-20 2003-04-03 Kyowa Hakko Kogyo Kk Pluripotent stem cells originating in skeletal muscle intestinal tissue
WO2007010858A1 (ja) 2005-07-15 2007-01-25 Kyoto University 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞
JP2009508511A (ja) 2005-09-19 2009-03-05 アシスタンス ピュブリク−オピトー ドゥ パリ ヒト平滑筋細胞の獲得方法およびヒト平滑筋細胞の適用
US20100273231A1 (en) 2005-09-20 2010-10-28 Andreadis Stelios T Multipotent mesenchymal stem cells from human hair follicles
US20140030236A1 (en) 2010-02-25 2014-01-30 The Johns Hopkins University Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
HK1052645B (en) 2000-04-14 2008-03-20 Universtiy Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
CN103230415B (zh) 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞（mdc）
TW200736399A (en) 2006-01-10 2007-10-01 Theradigm Inc Expansion and differentiation of neural stem cells under low oxygen conditions
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US20080208164A1 (en) 2007-02-28 2008-08-28 Innovacell Biotechnologie Gmbh Methods for the treatment of anal incontinence
CA2722758C (en) 2007-05-29 2017-04-25 Thomas Payne Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
EP2206774A1 (en) 2008-12-23 2010-07-14 Genzyme Corporation Muscle-derived cells having differentiation capacities
US20150030657A1 (en) * 2010-05-03 2015-01-29 Tengion, Inc. Smooth muscle cell constructs
US20150250826A1 (en) * 2012-09-06 2015-09-10 Joslin Diabetes Center, Inc. Isolation and characterization of muscle regenerating cells
EP2898089A1 (en) * 2012-09-24 2015-07-29 Innovacell Biotechnologie AG Potency assay for skeletal muscle derived cells
EP3056562A1 (en) * 2015-02-11 2016-08-17 University College Cork-National University of Ireland, Cork Induced smooth muscle-type cells, methods for the production thereof, and uses thereof in cell-based tissue regeneration and treatment of vascular occlusion
CN106350480B (zh) 2016-08-26 2019-11-08 中国农业科学院北京畜牧兽医研究所 一种纯化牛胎儿骨骼肌组织来源成肌细胞的方法
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
US20250114405A1 (en) 2021-08-06 2025-04-10 Innovacell Gmbh Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001103963A (ja) 1999-08-19 2001-04-17 Zen Bio Inc 脂肪組織由来の間質細胞に関する多様な中胚葉系統分化能およびその使用
WO2003027281A2 (en) 2001-09-20 2003-04-03 Kyowa Hakko Kogyo Kk Pluripotent stem cells originating in skeletal muscle intestinal tissue
WO2007010858A1 (ja) 2005-07-15 2007-01-25 Kyoto University 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞
JP2009508511A (ja) 2005-09-19 2009-03-05 アシスタンス ピュブリク−オピトー ドゥ パリ ヒト平滑筋細胞の獲得方法およびヒト平滑筋細胞の適用
US20100273231A1 (en) 2005-09-20 2010-10-28 Andreadis Stelios T Multipotent mesenchymal stem cells from human hair follicles
US20140030236A1 (en) 2010-02-25 2014-01-30 The Johns Hopkins University Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Gaby Nolazco et al.，BJU INTERNATIONAL，2008年，Vol. 101，pp. 1156-1164
Lu, S et al.，International Journal of Urology，Vol. 19, Suppl 1，2012年，p. 80, OP2305-01
Mitchel Seruya et al.，Cell Transplantation，2004年，Vol. 13，pp. 93-101
Shing-Hwa Lu et al.，International Journal of Urology，2010年，Vol. 17, Suppl 1，p. A348, PP30-26
Shing-Hwa Lu et al.，J. Cell. Mol. Med.，2011年，Vol. 15, No. 3，pp. 587-592
Sophie Le Ricousse-Roussanne et al.，EXPERIMENTAL CELL RESEARCH，2007年，Vol. 313，pp. 1337-1346
Won Sun Park et al.，Am J Physiol Cell Physiol，2013年，Vol. 305，pp. C377-C391
Zhaodi Gong et al.，TISSUE ENGINEERING: Part A，2009年，Vol. 15, No. 2

Also Published As

Publication number Publication date
US12312600B2 (en) 2025-05-27
AU2020247211B2 (en) 2024-07-04
EP4397752A3 (en) 2024-10-02
JP2025011242A (ja) 2025-01-23
CN120738111A (zh) 2025-10-03
US20220145257A1 (en) 2022-05-12
EP3942020B1 (en) 2024-05-15
CL2021002169A1 (es) 2022-02-25
AU2020247211A1 (en) 2021-07-29
EP4397752A2 (en) 2024-07-10
EP3942020A1 (en) 2022-01-26
DK3942020T3 (da) 2024-07-15
IL286509B1 (en) 2026-04-01
ZA202104948B (en) 2024-08-28
CN113614223A (zh) 2021-11-05
CN113614223B (zh) 2025-05-27
NZ778000A (en) 2025-07-25
IL286509A (en) 2021-10-31
WO2020193460A1 (en) 2020-10-01
CA3134213A1 (en) 2020-10-01
US20250207097A1 (en) 2025-06-26
ES2987152T3 (es) 2024-11-14
MX2021009862A (es) 2021-09-14
BR112021016264A2 (pt) 2021-10-13
KR20220002315A (ko) 2022-01-06
JP2022526229A (ja) 2022-05-24

Similar Documents

Publication Publication Date Title
JP2025011242A (ja) 誘導平滑筋細胞を得るための方法
JP7494430B2 (ja) 筋由来細胞を取得する方法
Tamaki et al. Synchronized reconstitution of muscle fibers, peripheral nerves and blood vessels by murine skeletal muscle-derived CD34−/45− cells
Oka et al. Characterization and localization of side population cells in the lens
Sadiasa et al. Steps towards the clinical application of endometrial and menstrual fluid mesenchymal stem cells for the treatment of gynecological disorders
WO2012115298A1 (ko) 양수 유래 줄기세포를 함유하는 요실금 치료제
CA3134213C (en) Methods for obtaining induced smooth muscle cells
RU2815906C9 (ru) Способы получения индуцированных клеток гладких мышц
RU2815906C2 (ru) Способы получения индуцированных клеток гладких мышц
HK40113062A (en) Methods for obtaining induced smooth muscle cells
HK40129485A (zh) 获得诱导性平滑肌细胞的方法
HK40064648B (en) Methods for obtaining induced smooth muscle cells
HK40064648A (en) Methods for obtaining induced smooth muscle cells
HK40063732B (zh) 获得诱导性平滑肌细胞的方法
HK40063732A (en) Methods for obtaining induced smooth muscle cells
RU2796929C2 (ru) Способы получения происходящих из мышц клеток
HK40098352A (en) Methods for obtaining muscle derived cells
KR20210046196A (ko) 말과동물 양막-유래 중간엽 줄기세포 및 이의 용도
HK40033933A (en) Methods for obtaining muscle derived cells
BR112020011853B1 (pt) Métodos para obtenção de células derivadas de músculos

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240104

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240329

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240618

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20241011

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20241016

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20241105

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241217

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241223

R150 Certificate of patent or registration of utility model

Ref document number: 7616665

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150