BR112021016264A2 - Métodos para obter células musculares lisas induzidas - Google Patents

Métodos para obter células musculares lisas induzidas Download PDF

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Publication number
BR112021016264A2
BR112021016264A2 BR112021016264-0A BR112021016264A BR112021016264A2 BR 112021016264 A2 BR112021016264 A2 BR 112021016264A2 BR 112021016264 A BR112021016264 A BR 112021016264A BR 112021016264 A2 BR112021016264 A2 BR 112021016264A2
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BR
Brazil
Prior art keywords
cells
ismcs
smooth muscle
mpcs
derived
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BR112021016264-0A
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English (en)
Portuguese (pt)
Inventor
Marco Thurner
Rainer Marksteiner
Original Assignee
Innovacell Ag
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Publication date
Application filed by Innovacell Ag filed Critical Innovacell Ag
Publication of BR112021016264A2 publication Critical patent/BR112021016264A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1323—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from skeletal muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
BR112021016264-0A 2019-03-22 2020-03-23 Métodos para obter células musculares lisas induzidas BR112021016264A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19164574 2019-03-22
EM19164574.6 2019-03-22
PCT/EP2020/057940 WO2020193460A1 (en) 2019-03-22 2020-03-23 Methods for obtaining induced smooth muscle cells

Publications (1)

Publication Number Publication Date
BR112021016264A2 true BR112021016264A2 (pt) 2021-10-13

Family

ID=65904308

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021016264-0A BR112021016264A2 (pt) 2019-03-22 2020-03-23 Métodos para obter células musculares lisas induzidas

Country Status (14)

Country Link
US (2) US12312600B2 (https=)
EP (2) EP3942020B1 (https=)
JP (2) JP7616665B2 (https=)
KR (1) KR20220002315A (https=)
CN (2) CN113614223B (https=)
AU (1) AU2020247211B2 (https=)
BR (1) BR112021016264A2 (https=)
CL (1) CL2021002169A1 (https=)
DK (1) DK3942020T3 (https=)
ES (1) ES2987152T3 (https=)
IL (1) IL286509B1 (https=)
MX (1) MX2021009862A (https=)
WO (1) WO2020193460A1 (https=)
ZA (1) ZA202104948B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
US20250114405A1 (en) 2021-08-06 2025-04-10 Innovacell Gmbh Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
HK1052645B (en) 2000-04-14 2008-03-20 Universtiy Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
JPWO2003027281A1 (ja) 2001-09-20 2005-01-06 協和醗酵工業株式会社 骨格筋間質由来多分化能幹細胞
CN103230415B (zh) 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞（mdc）
US20080213231A1 (en) 2005-07-15 2008-09-04 Kyoto University Pluripotent Stem Cell Cloned From Single Cell Derived From Skeletal Muscle Tissue
FR2890977A1 (fr) 2005-09-19 2007-03-23 Assist Publ Hopitaux De Paris Procede d'obtention de cellules musculaires lisses humaines et leurs applications
US20100273231A1 (en) 2005-09-20 2010-10-28 Andreadis Stelios T Multipotent mesenchymal stem cells from human hair follicles
TW200736399A (en) 2006-01-10 2007-10-01 Theradigm Inc Expansion and differentiation of neural stem cells under low oxygen conditions
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US20080208164A1 (en) 2007-02-28 2008-08-28 Innovacell Biotechnologie Gmbh Methods for the treatment of anal incontinence
CA2722758C (en) 2007-05-29 2017-04-25 Thomas Payne Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
EP2206774A1 (en) 2008-12-23 2010-07-14 Genzyme Corporation Muscle-derived cells having differentiation capacities
US20140030236A1 (en) 2010-02-25 2014-01-30 The Johns Hopkins University Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells
US20150030657A1 (en) * 2010-05-03 2015-01-29 Tengion, Inc. Smooth muscle cell constructs
US20150250826A1 (en) * 2012-09-06 2015-09-10 Joslin Diabetes Center, Inc. Isolation and characterization of muscle regenerating cells
EP2898089A1 (en) * 2012-09-24 2015-07-29 Innovacell Biotechnologie AG Potency assay for skeletal muscle derived cells
EP3056562A1 (en) * 2015-02-11 2016-08-17 University College Cork-National University of Ireland, Cork Induced smooth muscle-type cells, methods for the production thereof, and uses thereof in cell-based tissue regeneration and treatment of vascular occlusion
CN106350480B (zh) 2016-08-26 2019-11-08 中国农业科学院北京畜牧兽医研究所 一种纯化牛胎儿骨骼肌组织来源成肌细胞的方法
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
US20250114405A1 (en) 2021-08-06 2025-04-10 Innovacell Gmbh Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

Also Published As

Publication number Publication date
US12312600B2 (en) 2025-05-27
AU2020247211B2 (en) 2024-07-04
EP4397752A3 (en) 2024-10-02
JP2025011242A (ja) 2025-01-23
CN120738111A (zh) 2025-10-03
US20220145257A1 (en) 2022-05-12
EP3942020B1 (en) 2024-05-15
CL2021002169A1 (es) 2022-02-25
AU2020247211A1 (en) 2021-07-29
EP4397752A2 (en) 2024-07-10
EP3942020A1 (en) 2022-01-26
DK3942020T3 (da) 2024-07-15
JP7616665B2 (ja) 2025-01-17
IL286509B1 (en) 2026-04-01
ZA202104948B (en) 2024-08-28
CN113614223A (zh) 2021-11-05
CN113614223B (zh) 2025-05-27
NZ778000A (en) 2025-07-25
IL286509A (en) 2021-10-31
WO2020193460A1 (en) 2020-10-01
CA3134213A1 (en) 2020-10-01
US20250207097A1 (en) 2025-06-26
ES2987152T3 (es) 2024-11-14
MX2021009862A (es) 2021-09-14
KR20220002315A (ko) 2022-01-06
JP2022526229A (ja) 2022-05-24

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