CN113614223B - 获得诱导性平滑肌细胞的方法 - Google Patents

获得诱导性平滑肌细胞的方法 Download PDF

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CN113614223B
CN113614223B CN202080021489.4A CN202080021489A CN113614223B CN 113614223 B CN113614223 B CN 113614223B CN 202080021489 A CN202080021489 A CN 202080021489A CN 113614223 B CN113614223 B CN 113614223B
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cells
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smooth muscle
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CN113614223A (zh
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M.瑟纳
R.马克斯坦纳
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Inova Cell Co ltd
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1323—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from skeletal muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Engineering & Computer Science (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN202080021489.4A 2019-03-22 2020-03-23 获得诱导性平滑肌细胞的方法 Active CN113614223B (zh)

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CN202510688777.XA CN120738111A (zh) 2019-03-22 2020-03-23 获得诱导性平滑肌细胞的方法

Applications Claiming Priority (3)

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EP19164574.6 2019-03-22
EP19164574 2019-03-22
PCT/EP2020/057940 WO2020193460A1 (en) 2019-03-22 2020-03-23 Methods for obtaining induced smooth muscle cells

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US (2) US12312600B2 (https=)
EP (2) EP3942020B1 (https=)
JP (2) JP7616665B2 (https=)
KR (1) KR20220002315A (https=)
CN (2) CN113614223B (https=)
AU (1) AU2020247211B2 (https=)
BR (1) BR112021016264A2 (https=)
CL (1) CL2021002169A1 (https=)
DK (1) DK3942020T3 (https=)
ES (1) ES2987152T3 (https=)
IL (1) IL286509B1 (https=)
MX (1) MX2021009862A (https=)
WO (1) WO2020193460A1 (https=)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
US20250114405A1 (en) 2021-08-06 2025-04-10 Innovacell Gmbh Myogenic progenitor cells for use in an optimized method for the prevention and treatment of anal incontinence

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US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
HK1052645B (en) 2000-04-14 2008-03-20 Universtiy Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
JPWO2003027281A1 (ja) 2001-09-20 2005-01-06 協和醗酵工業株式会社 骨格筋間質由来多分化能幹細胞
CN103230415B (zh) 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞（mdc）
US20080213231A1 (en) 2005-07-15 2008-09-04 Kyoto University Pluripotent Stem Cell Cloned From Single Cell Derived From Skeletal Muscle Tissue
FR2890977A1 (fr) 2005-09-19 2007-03-23 Assist Publ Hopitaux De Paris Procede d'obtention de cellules musculaires lisses humaines et leurs applications
US20100273231A1 (en) 2005-09-20 2010-10-28 Andreadis Stelios T Multipotent mesenchymal stem cells from human hair follicles
TW200736399A (en) 2006-01-10 2007-10-01 Theradigm Inc Expansion and differentiation of neural stem cells under low oxygen conditions
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
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"Influence of Culture Medium on Smooth Muscle Cell Differentiation from Human Bone Marrow- Derived Mesenchymal Stem Cells";Zhaodi Gong 等;《Tissue Eng Part A.》;20091231;第15卷(第2期);摘要 *
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US12312600B2 (en) 2025-05-27
AU2020247211B2 (en) 2024-07-04
EP4397752A3 (en) 2024-10-02
JP2025011242A (ja) 2025-01-23
CN120738111A (zh) 2025-10-03
US20220145257A1 (en) 2022-05-12
EP3942020B1 (en) 2024-05-15
CL2021002169A1 (es) 2022-02-25
AU2020247211A1 (en) 2021-07-29
EP4397752A2 (en) 2024-07-10
EP3942020A1 (en) 2022-01-26
DK3942020T3 (da) 2024-07-15
JP7616665B2 (ja) 2025-01-17
IL286509B1 (en) 2026-04-01
ZA202104948B (en) 2024-08-28
CN113614223A (zh) 2021-11-05
NZ778000A (en) 2025-07-25
IL286509A (en) 2021-10-31
WO2020193460A1 (en) 2020-10-01
CA3134213A1 (en) 2020-10-01
US20250207097A1 (en) 2025-06-26
ES2987152T3 (es) 2024-11-14
MX2021009862A (es) 2021-09-14
BR112021016264A2 (pt) 2021-10-13
KR20220002315A (ko) 2022-01-06
JP2022526229A (ja) 2022-05-24

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