JP7611136B2 - 別の薬理学的に活性な薬剤と組み合わせた長時間作用型インターロイキン－１５受容体作動薬 - Google Patents

別の薬理学的に活性な薬剤と組み合わせた長時間作用型インターロイキン－１５受容体作動薬 Download PDF

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JP7611136B2
JP7611136B2 JP2021524370A JP2021524370A JP7611136B2 JP 7611136 B2 JP7611136 B2 JP 7611136B2 JP 2021524370 A JP2021524370 A JP 2021524370A JP 2021524370 A JP2021524370 A JP 2021524370A JP 7611136 B2 JP7611136 B2 JP 7611136B2
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宇広 宮崎
ルイ マダカムティル，
サウル キヴィメイ，
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ネクター セラピューティクス
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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JP2021524370A 2018-11-09 2019-11-08 別の薬理学的に活性な薬剤と組み合わせた長時間作用型インターロイキン－１５受容体作動薬 Active JP7611136B2 (ja)

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JP2024226179A JP2025041784A (ja) 2018-11-09 2024-12-23 別の薬理学的に活性な薬剤と組み合わせた長時間作用型インターロイキン－１５受容体作動薬

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US201862758344P 2018-11-09 2018-11-09
US62/758,344 2018-11-09
US201962789924P 2019-01-08 2019-01-08
US62/789,924 2019-01-08
US201962818003P 2019-03-13 2019-03-13
US62/818,003 2019-03-13
US201962825437P 2019-03-28 2019-03-28
US62/825,437 2019-03-28
US201962843036P 2019-05-03 2019-05-03
US62/843,036 2019-05-03
US201962848372P 2019-05-15 2019-05-15
US62/848,372 2019-05-15
US201962924015P 2019-10-21 2019-10-21
US62/924,015 2019-10-21
PCT/US2019/060609 WO2020097556A1 (en) 2018-11-09 2019-11-08 Long-acting interleukin-15 receptor agonist in combination with another pharmacologically active agent

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Families Citing this family (7)

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IT201900022590A1 (it) 2019-11-29 2021-05-29 Italtractor Sistema di monitoraggio per sottocarro cingolato
WO2022200525A1 (en) 2021-03-26 2022-09-29 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
EP4346904A1 (en) * 2021-06-03 2024-04-10 Synthorx, Inc. Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014521594A (ja) 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2014534250A (ja) 2011-11-25 2014-12-18 ロシュ グリクアート アーゲー 抗ｃｄ２０抗体とヒトｉｌ−１５を用いる併用療法
JP2017511322A (ja) 2014-04-03 2017-04-20 ネクター セラピューティクス Ｉｌ−１５部分とポリマーとのコンジュゲート
JP2017521410A (ja) 2014-06-30 2017-08-03 アルター・バイオサイエンス・コーポレーション Ｉｌ−１５ベース分子及びその使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
CN101743249B (zh) * 2007-05-11 2017-08-08 阿尔托生物科学有限公司 融合分子与il‑15变异体
EA201892619A1 (ru) * 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
WO2016060996A2 (en) * 2014-10-14 2016-04-21 Armo Biosciences, Inc. Interleukin-15 compositions and uses thereof
MX2018007304A (es) * 2015-12-21 2019-03-14 Armo Biosciences Inc Composiciones de interleucina-15 y sus usos.
IL270634B2 (en) * 2017-05-15 2025-06-01 Nektar Therapeutics Long-acting interleukin-15 receptor agonists and related immunotherapeutic compositions and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014521594A (ja) 2011-05-25 2014-08-28 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー 長持続期間デュアルホルモンコンジュゲート
JP2014534250A (ja) 2011-11-25 2014-12-18 ロシュ グリクアート アーゲー 抗ｃｄ２０抗体とヒトｉｌ−１５を用いる併用療法
JP2017511322A (ja) 2014-04-03 2017-04-20 ネクター セラピューティクス Ｉｌ−１５部分とポリマーとのコンジュゲート
JP2017521410A (ja) 2014-06-30 2017-08-03 アルター・バイオサイエンス・コーポレーション Ｉｌ−１５ベース分子及びその使用方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Breast Cancer Research and Treatment，2011年，Vol.130，pp.465-475
CELLULAR IMMUNOLOGY，1998年，Vol.185，pp.83-92
Drug Delivery System，2016年，Vol.31, No.4，pp.268-274
PNAS，2018年10月29日，vol.115, No.46，E10915-E10924
医学のあゆみ，2000年，Vol.195, No.1，pp.91-95

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EP3876974A4 (en) 2022-11-23
WO2020097556A1 (en) 2020-05-14
MX2021005485A (es) 2021-06-18
JP2022512944A (ja) 2022-02-07
US20210393742A1 (en) 2021-12-23
AU2019376164B2 (en) 2025-10-16
AU2019376164A1 (en) 2021-05-27
EP3876974A1 (en) 2021-09-15
CA3119049A1 (en) 2020-05-14
JP2025041784A (ja) 2025-03-26
CN112955168A (zh) 2021-06-11
KR20210090203A (ko) 2021-07-19

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