JP7605825B2 - 併用療法のための化合物 - Google Patents

併用療法のための化合物 Download PDF

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JP7605825B2
JP7605825B2 JP2022506360A JP2022506360A JP7605825B2 JP 7605825 B2 JP7605825 B2 JP 7605825B2 JP 2022506360 A JP2022506360 A JP 2022506360A JP 2022506360 A JP2022506360 A JP 2022506360A JP 7605825 B2 JP7605825 B2 JP 7605825B2
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compound
pharmaceutical composition
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erectile dysfunction
depression
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Japanese (ja)
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JP2022544463A5 (https=
JP2022544463A (ja
Inventor
シモンセン，ウルフ
コメルマ－ステッフェンセン，シモン
ピータース，ダン
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イニシエーター ファーマ エー／エス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
JP2022506360A 2019-08-06 2020-08-06 併用療法のための化合物 Active JP7605825B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19190224.6 2019-08-06
EP19190224 2019-08-06
PCT/EP2020/072092 WO2021023805A1 (en) 2019-08-06 2020-08-06 Compound for combination treatment

Publications (3)

Publication Number Publication Date
JP2022544463A JP2022544463A (ja) 2022-10-19
JP2022544463A5 JP2022544463A5 (https=) 2023-08-15
JP7605825B2 true JP7605825B2 (ja) 2024-12-24

Family

ID=67551141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022506360A Active JP7605825B2 (ja) 2019-08-06 2020-08-06 併用療法のための化合物

Country Status (16)

Country Link
US (1) US20220288052A1 (https=)
EP (2) EP4009942B1 (https=)
JP (1) JP7605825B2 (https=)
KR (1) KR20220054593A (https=)
CN (1) CN114430679A (https=)
AU (1) AU2020326244B2 (https=)
BR (1) BR112022002169A2 (https=)
CA (1) CA3146837A1 (https=)
DK (1) DK4009942T3 (https=)
ES (1) ES2962648T3 (https=)
FI (1) FI4009942T3 (https=)
IL (1) IL290319B2 (https=)
MX (1) MX2022000356A (https=)
PL (1) PL4009942T3 (https=)
WO (1) WO2021023805A1 (https=)
ZA (1) ZA202200723B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4646204A1 (en) * 2023-01-03 2025-11-12 Initiator Pharma A/S Compound for treatment of erectile dysfunction
WO2025051846A1 (en) 2023-09-05 2025-03-13 Initiator Pharma A/S Compound for treatment of female sexual dysfunction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514676A (ja) 2004-09-30 2008-05-08 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用
JP2010513392A (ja) 2006-12-20 2010-04-30 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2012500248A (ja) 2008-08-21 2012-01-05 ノイロサーチ アクティーゼルスカブ 不安障害の治療
US20140235669A1 (en) 2010-01-29 2014-08-21 Aniona Aps Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04012693A (es) * 2002-06-20 2005-03-23 Lundbeck & Co As H Terapia de combinacion en donde se utiliza un inhibidor de recaptacion de serotonina.
RU2354377C2 (ru) * 2003-07-11 2009-05-10 Берингер Ингельхайм Ветмедика Гмбх Способ лечения или предупреждения заболеваний центральной нервной системы с использованием соединений, обладающих селективностью в отношении альфа-3-субъединицы бензодиазепинового рецептора

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514676A (ja) 2004-09-30 2008-05-08 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのその使用
JP2010513392A (ja) 2006-12-20 2010-04-30 ノイロサーチ アクティーゼルスカブ 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用
JP2012500248A (ja) 2008-08-21 2012-01-05 ノイロサーチ アクティーゼルスカブ 不安障害の治療
US20140235669A1 (en) 2010-01-29 2014-08-21 Aniona Aps Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ulf SIMONSEN et al.，"Modulation of Dopaminergic Pathways to Treat Erectile Dysfunction"，Basic & Clinical Pharmacology & Toxicology，2016年，Vol.119，p.63-74，DOI: 10.1111/bcpt.12653
Yasuyuki ICHIMARU et al.，"5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice"，Japanese Journal of Pharmacology，1995年，Vol.68，p.65-70，DOI: 10.1254/jjp.68.65

Also Published As

Publication number Publication date
WO2021023805A1 (en) 2021-02-11
MX2022000356A (es) 2022-05-11
FI4009942T3 (fi) 2023-09-26
CN114430679A (zh) 2022-05-03
ES2962648T3 (es) 2024-03-20
BR112022002169A2 (pt) 2022-06-07
AU2020326244B2 (en) 2025-06-05
AU2020326244A1 (en) 2022-03-17
IL290319A (en) 2022-04-01
IL290319B2 (en) 2023-06-01
DK4009942T3 (da) 2023-10-23
EP4009942B1 (en) 2023-08-09
EP4009942A1 (en) 2022-06-15
CA3146837A1 (en) 2021-02-11
ZA202200723B (en) 2022-08-31
EP4241839A2 (en) 2023-09-13
US20220288052A1 (en) 2022-09-15
JP2022544463A (ja) 2022-10-19
PL4009942T3 (pl) 2024-04-08
EP4241839A3 (en) 2023-11-15
KR20220054593A (ko) 2022-05-03

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