JP7601359B2 - 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法 - Google Patents

血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法 Download PDF

Info

Publication number
JP7601359B2
JP7601359B2 JP2023524251A JP2023524251A JP7601359B2 JP 7601359 B2 JP7601359 B2 JP 7601359B2 JP 2023524251 A JP2023524251 A JP 2023524251A JP 2023524251 A JP2023524251 A JP 2023524251A JP 7601359 B2 JP7601359 B2 JP 7601359B2
Authority
JP
Japan
Prior art keywords
collection container
blood collection
blood
plasma
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023524251A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022250142A5 (https=
JPWO2022250142A1 (https=
Inventor
邦哉 駒井
嵩也 内山
まりか 神田
智雅 井上
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sekisui Medical Co Ltd
Original Assignee
Sekisui Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Medical Co Ltd filed Critical Sekisui Medical Co Ltd
Publication of JPWO2022250142A1 publication Critical patent/JPWO2022250142A1/ja
Publication of JPWO2022250142A5 publication Critical patent/JPWO2022250142A5/ja
Application granted granted Critical
Publication of JP7601359B2 publication Critical patent/JP7601359B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2023524251A 2021-05-28 2022-05-27 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法 Active JP7601359B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021090433 2021-05-28
JP2021090433 2021-05-28
PCT/JP2022/021743 WO2022250142A1 (ja) 2021-05-28 2022-05-27 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法

Publications (3)

Publication Number Publication Date
JPWO2022250142A1 JPWO2022250142A1 (https=) 2022-12-01
JPWO2022250142A5 JPWO2022250142A5 (https=) 2023-11-01
JP7601359B2 true JP7601359B2 (ja) 2024-12-17

Family

ID=84228957

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023524251A Active JP7601359B2 (ja) 2021-05-28 2022-05-27 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法

Country Status (7)

Country Link
US (1) US20240245844A1 (https=)
EP (1) EP4350348A4 (https=)
JP (1) JP7601359B2 (https=)
KR (1) KR20240013088A (https=)
CN (1) CN117413181A (https=)
CA (1) CA3218292A1 (https=)
WO (1) WO2022250142A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2024204675A1 (https=) * 2023-03-29 2024-10-03
JP7670408B1 (ja) 2024-03-22 2025-04-30 積水メディカル株式会社 血液採取容器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005017189A (ja) 2003-06-27 2005-01-20 Srl Inc 血中インスリン濃度測定用添加剤組成物及びそれを含む採血管
WO2016159236A1 (ja) 2015-03-31 2016-10-06 積水メディカル株式会社 血清または血漿分離用組成物、並びに血液採取容器
JP2021500585A (ja) 2017-10-19 2021-01-07 ストレック， インコーポレイテッド 溶血、凝固調節および細胞外小胞の安定化のための組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4260303B2 (ja) * 1999-09-09 2009-04-30 旭化成ファーマ株式会社 血液処理方法および組成物
EP2360470A4 (en) * 2008-11-07 2013-01-02 Hitachi Chemical Co Ltd BLOOD SERUM OR BLOOD PLASMA SEPARATOR MATERIAL AND BLOOD COLLECTION TUBE USING THE SAME
PL3006109T3 (pl) 2009-05-15 2019-12-31 Becton, Dickinson And Company Urządzenie do rozdzielania faz gęstości
CN109266531A (zh) * 2018-10-08 2019-01-25 陈琼娣 一种外周血单个核细胞分离管及其制备方法
WO2020132747A1 (en) 2018-12-24 2020-07-02 Deltadna Biosciences Inc Composition and method for segregating extracellular dna in blood

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005017189A (ja) 2003-06-27 2005-01-20 Srl Inc 血中インスリン濃度測定用添加剤組成物及びそれを含む採血管
WO2016159236A1 (ja) 2015-03-31 2016-10-06 積水メディカル株式会社 血清または血漿分離用組成物、並びに血液採取容器
JP2021500585A (ja) 2017-10-19 2021-01-07 ストレック， インコーポレイテッド 溶血、凝固調節および細胞外小胞の安定化のための組成物

Also Published As

Publication number Publication date
US20240245844A1 (en) 2024-07-25
EP4350348A1 (en) 2024-04-10
WO2022250142A1 (ja) 2022-12-01
KR20240013088A (ko) 2024-01-30
JPWO2022250142A1 (https=) 2022-12-01
CA3218292A1 (en) 2022-12-01
CN117413181A (zh) 2024-01-16
EP4350348A4 (en) 2025-06-04

Similar Documents

Publication Publication Date Title
JP6901194B1 (ja) 血液採取容器及び血漿の分離方法
JP7803493B2 (ja) 白血球濃縮分離デバイス、血液採取容器及び白血球の分離方法
JP7169608B1 (ja) 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法
JP7601359B2 (ja) 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法
EP3734273B1 (en) Composition for separating blood serum or blood plasma, use of the composition, blood collection container, and method for separating blood serum or blood plasma
US20250073703A1 (en) Blood collection container, method for separating plasma, method for separating extracellular free nucleic acid, and method for separating extracellular vesicle
JP7768638B1 (ja) 血液採取容器、血漿の分離方法、細胞外遊離核酸の分離方法及び細胞外小胞の分離方法
JP7355473B1 (ja) 循環腫瘍細胞分離キット、循環腫瘍細胞分離容器及び循環腫瘍細胞の分離方法
JPWO2020235544A1 (ja) 単核球含有血漿分離用組成物及び血液採取容器
CA3157473C (en) Blood collection container and plasma separation method
JP7779617B1 (ja) 血液採取容器及び血漿の分離方法
WO2024204675A1 (ja) 血液採取容器及び血漿の分離方法
JP7670408B1 (ja) 血液採取容器
JP7609510B1 (ja) 血液採取容器及び単核球の分離方法
US20250331750A1 (en) Separating gel for blood collection tubes
WO2026054038A1 (ja) 血球分離用水溶液、血液採取容器及び単核球の分離方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230804

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230804

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241105

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241127

R150 Certificate of patent or registration of utility model

Ref document number: 7601359

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150