JP7590737B2 - CD1a陽性癌の治療のためのCAR T細胞 - Google Patents
CD1a陽性癌の治療のためのCAR T細胞 Download PDFInfo
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- JP7590737B2 JP7590737B2 JP2021547571A JP2021547571A JP7590737B2 JP 7590737 B2 JP7590737 B2 JP 7590737B2 JP 2021547571 A JP2021547571 A JP 2021547571A JP 2021547571 A JP2021547571 A JP 2021547571A JP 7590737 B2 JP7590737 B2 JP 7590737B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4213—CD74, Ii, MHC class II invariant chain or MHC class II gamma chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024195152A JP2025024031A (ja) | 2019-02-14 | 2024-11-07 | CD1a陽性癌の治療のためのCAR T細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382104.8 | 2019-02-14 | ||
| EP19382104.8A EP3696191A1 (en) | 2019-02-14 | 2019-02-14 | Car t-cells for the treatment of cd1a-positive cancer |
| PCT/EP2020/053769 WO2020165350A1 (en) | 2019-02-14 | 2020-02-13 | Car t-cells for the treatment of cd1a-positive cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195152A Division JP2025024031A (ja) | 2019-02-14 | 2024-11-07 | CD1a陽性癌の治療のためのCAR T細胞 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022520455A JP2022520455A (ja) | 2022-03-30 |
| JP2022520455A5 JP2022520455A5 (https=) | 2023-02-21 |
| JPWO2020165350A5 JPWO2020165350A5 (https=) | 2023-02-21 |
| JP7590737B2 true JP7590737B2 (ja) | 2024-11-27 |
Family
ID=65685281
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021547571A Active JP7590737B2 (ja) | 2019-02-14 | 2020-02-13 | CD1a陽性癌の治療のためのCAR T細胞 |
| JP2024195152A Pending JP2025024031A (ja) | 2019-02-14 | 2024-11-07 | CD1a陽性癌の治療のためのCAR T細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024195152A Pending JP2025024031A (ja) | 2019-02-14 | 2024-11-07 | CD1a陽性癌の治療のためのCAR T細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12215158B2 (https=) |
| EP (2) | EP3696191A1 (https=) |
| JP (2) | JP7590737B2 (https=) |
| CN (2) | CN118436770A (https=) |
| AU (1) | AU2020222239B2 (https=) |
| CA (1) | CA3128955A1 (https=) |
| MX (1) | MX2021009798A (https=) |
| WO (1) | WO2020165350A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3696191A1 (en) * | 2019-02-14 | 2020-08-19 | Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) | Car t-cells for the treatment of cd1a-positive cancer |
| US11746154B2 (en) | 2020-10-09 | 2023-09-05 | Pfizer Inc. | CD1a antibodies and uses thereof |
| AU2022282828A1 (en) * | 2021-05-26 | 2023-12-14 | Oxford University Innovation Limited | Antibodies |
| IT202100027929A1 (it) * | 2021-11-02 | 2023-05-02 | Univ Degli Studi Magna Graecia Di Catanzaro | Un nuovo anticorpo bispecifico asimmetrico(UMG2/CD1a-CD3e) per il trattamento immunologico della forma corticale di leucemia linfoblastica acuta T (T-ALL) pediatrica e dell’adulto |
| EP4234582A1 (en) * | 2022-02-28 | 2023-08-30 | Onechain Immunotherapeutics SL | Humanized cd1a targeting moiety for the treatment of cd1a-positive cancer |
| CA3251493A1 (en) * | 2022-02-28 | 2023-08-31 | Onechain Immunotherapeutics S.L | Humanized CD1A Targeting Fraction for Treating CD1A-Positive Cancer |
| GB202217923D0 (en) * | 2022-11-29 | 2023-01-11 | Univ Oxford Innovation Ltd | Antibodies |
| EP4417623A1 (en) * | 2023-02-15 | 2024-08-21 | Fundació Institut de Recerca Contra la Leucèmia Josep Carreras | Ccr9 targeting moiety for the treatment of ccr9-positive cancer |
| EP4545085A1 (en) * | 2023-10-26 | 2025-04-30 | Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | Car t-cells against cd79b for the treatment of non-hodgkin lymphoma |
| CN119685260B (zh) * | 2024-12-17 | 2026-01-13 | 上海交通大学医学院附属瑞金医院 | 一种具有新型穿膜区的嵌合抗原受体t细胞及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018522833A (ja) | 2015-06-12 | 2018-08-16 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| GB0717101D0 (en) * | 2007-09-03 | 2007-10-10 | Cambridge Entpr Ltd | Tumour marker |
| AU2015327868A1 (en) | 2014-10-03 | 2017-04-20 | Novartis Ag | Combination therapies |
| EP3696191A1 (en) * | 2019-02-14 | 2020-08-19 | Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) | Car t-cells for the treatment of cd1a-positive cancer |
-
2019
- 2019-02-14 EP EP19382104.8A patent/EP3696191A1/en not_active Withdrawn
-
2020
- 2020-02-13 EP EP20706418.9A patent/EP3924374A1/en active Pending
- 2020-02-13 MX MX2021009798A patent/MX2021009798A/es unknown
- 2020-02-13 US US17/430,705 patent/US12215158B2/en active Active
- 2020-02-13 WO PCT/EP2020/053769 patent/WO2020165350A1/en not_active Ceased
- 2020-02-13 CA CA3128955A patent/CA3128955A1/en active Pending
- 2020-02-13 JP JP2021547571A patent/JP7590737B2/ja active Active
- 2020-02-13 AU AU2020222239A patent/AU2020222239B2/en active Active
- 2020-02-13 CN CN202410679216.9A patent/CN118436770A/zh active Pending
- 2020-02-13 CN CN202080028333.9A patent/CN113795506A/zh active Pending
-
2024
- 2024-11-07 JP JP2024195152A patent/JP2025024031A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018522833A (ja) | 2015-06-12 | 2018-08-16 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療 |
Non-Patent Citations (3)
| Title |
|---|
| EXPERIMENTAL HEMATOLOGY,2018年08月22日,Vol. 64, No. 22,p. S85, 3107 |
| JOURNAL OF INVESTIGATIVE DERMATOLOGY,2000年,Vol . 114, No. 1,p. 127-134 |
| KLINISCHE PAEDIATRIE,2018年04月01日,Vol. 230, No. 3,p. 174, 39 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022520455A (ja) | 2022-03-30 |
| US12215158B2 (en) | 2025-02-04 |
| MX2021009798A (es) | 2021-11-17 |
| AU2020222239A1 (en) | 2021-10-07 |
| JP2025024031A (ja) | 2025-02-19 |
| AU2020222239B2 (en) | 2024-12-05 |
| EP3696191A1 (en) | 2020-08-19 |
| CN113795506A (zh) | 2021-12-14 |
| CN118436770A (zh) | 2024-08-06 |
| EP3924374A1 (en) | 2021-12-22 |
| CA3128955A1 (en) | 2020-08-20 |
| US20220143085A1 (en) | 2022-05-12 |
| WO2020165350A1 (en) | 2020-08-20 |
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