JP7590737B2 - CD1a陽性癌の治療のためのCAR T細胞 - Google Patents

CD1a陽性癌の治療のためのCAR T細胞 Download PDF

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JP7590737B2
JP7590737B2 JP2021547571A JP2021547571A JP7590737B2 JP 7590737 B2 JP7590737 B2 JP 7590737B2 JP 2021547571 A JP2021547571 A JP 2021547571A JP 2021547571 A JP2021547571 A JP 2021547571A JP 7590737 B2 JP7590737 B2 JP 7590737B2
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JP2022520455A (ja
JP2022520455A5 (https=
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ブハン パブロ メネンデス
マルティネス ディエゴ サンチェス
ウロス クララ ブエノ
アグエラ フランシスコ グティエレス
ヘレイア ロカ-オ
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フンダシオン インスティテュート デ インヴェスティガシオン コントラ ラ レウセミア ジュゼップ カレラス (アイジェイシー)
インスティトゥシオ カタラーナ デ レセルカ イ エストゥディス アバンカツ (アイシーアールイーエー)
フンダシオ インスティテュート ディンベスティガシオ エン シエンシエス デ ラ サリュ ジャーマンス トライアス アイ プジョル
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JP2021547571A 2019-02-14 2020-02-13 CD1a陽性癌の治療のためのCAR T細胞 Active JP7590737B2 (ja)

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JP2024195152A JP2025024031A (ja) 2019-02-14 2024-11-07 CD1a陽性癌の治療のためのCAR T細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382104.8 2019-02-14
EP19382104.8A EP3696191A1 (en) 2019-02-14 2019-02-14 Car t-cells for the treatment of cd1a-positive cancer
PCT/EP2020/053769 WO2020165350A1 (en) 2019-02-14 2020-02-13 Car t-cells for the treatment of cd1a-positive cancer

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JP2022520455A JP2022520455A (ja) 2022-03-30
JP2022520455A5 JP2022520455A5 (https=) 2023-02-21
JPWO2020165350A5 JPWO2020165350A5 (https=) 2023-02-21
JP7590737B2 true JP7590737B2 (ja) 2024-11-27

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JP2021547571A Active JP7590737B2 (ja) 2019-02-14 2020-02-13 CD1a陽性癌の治療のためのCAR T細胞
JP2024195152A Pending JP2025024031A (ja) 2019-02-14 2024-11-07 CD1a陽性癌の治療のためのCAR T細胞

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US (1) US12215158B2 (https=)
EP (2) EP3696191A1 (https=)
JP (2) JP7590737B2 (https=)
CN (2) CN118436770A (https=)
AU (1) AU2020222239B2 (https=)
CA (1) CA3128955A1 (https=)
MX (1) MX2021009798A (https=)
WO (1) WO2020165350A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3696191A1 (en) * 2019-02-14 2020-08-19 Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) Car t-cells for the treatment of cd1a-positive cancer
US11746154B2 (en) 2020-10-09 2023-09-05 Pfizer Inc. CD1a antibodies and uses thereof
AU2022282828A1 (en) * 2021-05-26 2023-12-14 Oxford University Innovation Limited Antibodies
IT202100027929A1 (it) * 2021-11-02 2023-05-02 Univ Degli Studi Magna Graecia Di Catanzaro Un nuovo anticorpo bispecifico asimmetrico(UMG2/CD1a-CD3e) per il trattamento immunologico della forma corticale di leucemia linfoblastica acuta T (T-ALL) pediatrica e dell’adulto
EP4234582A1 (en) * 2022-02-28 2023-08-30 Onechain Immunotherapeutics SL Humanized cd1a targeting moiety for the treatment of cd1a-positive cancer
CA3251493A1 (en) * 2022-02-28 2023-08-31 Onechain Immunotherapeutics S.L Humanized CD1A Targeting Fraction for Treating CD1A-Positive Cancer
GB202217923D0 (en) * 2022-11-29 2023-01-11 Univ Oxford Innovation Ltd Antibodies
EP4417623A1 (en) * 2023-02-15 2024-08-21 Fundació Institut de Recerca Contra la Leucèmia Josep Carreras Ccr9 targeting moiety for the treatment of ccr9-positive cancer
EP4545085A1 (en) * 2023-10-26 2025-04-30 Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz Car t-cells against cd79b for the treatment of non-hodgkin lymphoma
CN119685260B (zh) * 2024-12-17 2026-01-13 上海交通大学医学院附属瑞金医院 一种具有新型穿膜区的嵌合抗原受体t细胞及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522833A (ja) 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドImmunomedics, Inc. キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
EP0575485A1 (en) 1991-03-01 1993-12-29 Dyax Corp. Process for the development of binding mini-proteins
DK0580737T3 (da) 1991-04-10 2004-11-01 Scripps Research Inst Heterodimere receptorbiblioteker ved anvendelse af phagemider
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
GB0717101D0 (en) * 2007-09-03 2007-10-10 Cambridge Entpr Ltd Tumour marker
AU2015327868A1 (en) 2014-10-03 2017-04-20 Novartis Ag Combination therapies
EP3696191A1 (en) * 2019-02-14 2020-08-19 Fundación Instituto de Investigación contra la Leucemia Josep Carreras (IJC) Car t-cells for the treatment of cd1a-positive cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522833A (ja) 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドImmunomedics, Inc. キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EXPERIMENTAL HEMATOLOGY,2018年08月22日,Vol. 64, No. 22,p. S85, 3107
JOURNAL OF INVESTIGATIVE DERMATOLOGY,2000年,Vol . 114, No. 1,p. 127-134
KLINISCHE PAEDIATRIE,2018年04月01日,Vol. 230, No. 3,p. 174, 39

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Publication number Publication date
JP2022520455A (ja) 2022-03-30
US12215158B2 (en) 2025-02-04
MX2021009798A (es) 2021-11-17
AU2020222239A1 (en) 2021-10-07
JP2025024031A (ja) 2025-02-19
AU2020222239B2 (en) 2024-12-05
EP3696191A1 (en) 2020-08-19
CN113795506A (zh) 2021-12-14
CN118436770A (zh) 2024-08-06
EP3924374A1 (en) 2021-12-22
CA3128955A1 (en) 2020-08-20
US20220143085A1 (en) 2022-05-12
WO2020165350A1 (en) 2020-08-20

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