JP7575104B2 - ナチュラルキラー細胞およびキメラ抗原受容体改変された細胞の拡大増殖 - Google Patents
ナチュラルキラー細胞およびキメラ抗原受容体改変された細胞の拡大増殖 Download PDFInfo
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- JP7575104B2 JP7575104B2 JP2021548697A JP2021548697A JP7575104B2 JP 7575104 B2 JP7575104 B2 JP 7575104B2 JP 2021548697 A JP2021548697 A JP 2021548697A JP 2021548697 A JP2021548697 A JP 2021548697A JP 7575104 B2 JP7575104 B2 JP 7575104B2
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
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- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
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- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Toxicology (AREA)
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- Plant Pathology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962808031P | 2019-02-20 | 2019-02-20 | |
| US62/808,031 | 2019-02-20 | ||
| PCT/US2020/018897 WO2020172328A1 (en) | 2019-02-20 | 2020-02-19 | Expansion of natural killer and chimeric antigen receptor-modified cells |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022520871A JP2022520871A (ja) | 2022-04-01 |
| JP2022520871A5 JP2022520871A5 (https=) | 2023-02-10 |
| JPWO2020172328A5 JPWO2020172328A5 (https=) | 2023-02-10 |
| JP7575104B2 true JP7575104B2 (ja) | 2024-10-29 |
Family
ID=72143864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021548697A Active JP7575104B2 (ja) | 2019-02-20 | 2020-02-19 | ナチュラルキラー細胞およびキメラ抗原受容体改変された細胞の拡大増殖 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12453773B2 (https=) |
| EP (1) | EP3927730A4 (https=) |
| JP (1) | JP7575104B2 (https=) |
| CN (1) | CN113710691B (https=) |
| CA (1) | CA3131879A1 (https=) |
| WO (1) | WO2020172328A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| EP3746095A4 (en) | 2018-02-01 | 2021-04-21 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| EP4209586B1 (en) * | 2020-09-04 | 2025-10-29 | Daegu Gyeongbuk Institute Of Science and Technology | Extracellular vesicle expressing cytokine and antibody, method for producing same, and use thereof |
| EP4501336A4 (en) * | 2022-03-24 | 2025-10-15 | Therabest Co Ltd | Pharmaceutical composition for the prevention or treatment of degenerative brain diseases with natural killer cells |
| WO2023205733A1 (en) * | 2022-04-21 | 2023-10-26 | Academia Sinica | Genetically engineered innate lymphoid cells for enhancing lifespan and/or treating cancers |
| CN114736859B (zh) * | 2022-06-13 | 2022-08-19 | 广东先康达生物科技有限公司 | 一种脐带血nk细胞的培养液及培养方法 |
| CN116254230A (zh) * | 2022-09-14 | 2023-06-13 | 卡瑞济(北京)生命科技有限公司 | 用于制备和扩增通用型人源化抗cd19 car-nk细胞的方法及其用途 |
| CN115612673A (zh) * | 2022-12-14 | 2023-01-17 | 卡瑞济(北京)生命科技有限公司 | 一种改善car-t细胞群的持久性的方法 |
| CN116554300B (zh) * | 2023-04-27 | 2023-10-24 | 湖北医药学院 | 一种能与艰难拟梭菌毒素TcdB相互作用的多肽及其应用 |
| AU2024298429A1 (en) * | 2023-07-21 | 2026-01-29 | Gaia Biomedicine Inc. | Method for producing cell population |
| CN117187181B (zh) * | 2023-11-08 | 2024-03-19 | 普华赛尔生物医疗科技有限公司 | 包被组合物的方法及其应用 |
| WO2025178407A1 (ko) * | 2024-02-23 | 2025-08-28 | 마루테라퓨틱스 주식회사 | 고효율 유도 자연살해세포(ink) 증식 방법 |
| WO2025251226A1 (en) * | 2024-06-05 | 2025-12-11 | Nuwacell Biotechnologies Co., Ltd. | Use of interleukin-21 and interleukin-15 for enhancing serial killing of natural killer cell for cell therapy against target cell |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020516238A (ja) | 2017-03-27 | 2020-06-11 | ナショナル ユニヴァーシティ オブ シンガポール | ナチュラルキラー細胞のエクスビボ拡大及び活性化のための刺激細胞株 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7005127B2 (en) | 2002-03-29 | 2006-02-28 | Tissuegene, Inc. | Mixed-cell gene therapy |
| CN102559600A (zh) * | 2011-12-29 | 2012-07-11 | 上海交通大学医学院 | 一种人工抗原递呈细胞及其在nk细胞扩增中的应用 |
| WO2015154012A1 (en) * | 2014-04-03 | 2015-10-08 | Memorial Sloan-Kettering Cancer Center | Clonogenic natural killer (nk) cell populations and methods of producing and using such populations |
| AU2015273501B2 (en) * | 2014-06-11 | 2021-01-21 | Polybiocept Gmbh | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
| CN109844099B (zh) * | 2016-07-25 | 2024-01-02 | 美国政府(由卫生和人类服务部的部长所代表) | 产生经修饰的自然杀伤细胞的方法及使用方法 |
| CA3041831A1 (en) * | 2016-10-27 | 2018-05-03 | Intima Bioscience, Inc. | Viral methods of making genetically modified cells |
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2020
- 2020-02-19 EP EP20758646.2A patent/EP3927730A4/en active Pending
- 2020-02-19 CN CN202080029826.4A patent/CN113710691B/zh active Active
- 2020-02-19 WO PCT/US2020/018897 patent/WO2020172328A1/en not_active Ceased
- 2020-02-19 CA CA3131879A patent/CA3131879A1/en active Pending
- 2020-02-19 US US17/432,380 patent/US12453773B2/en active Active
- 2020-02-19 JP JP2021548697A patent/JP7575104B2/ja active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020516238A (ja) | 2017-03-27 | 2020-06-11 | ナショナル ユニヴァーシティ オブ シンガポール | ナチュラルキラー細胞のエクスビボ拡大及び活性化のための刺激細胞株 |
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| Journal of Leukocyte Biology,2015年,Vol.97,pp.761-767 |
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| JP2022520871A (ja) | 2022-04-01 |
| EP3927730A4 (en) | 2022-12-21 |
| US20220152102A1 (en) | 2022-05-19 |
| US12453773B2 (en) | 2025-10-28 |
| EP3927730A1 (en) | 2021-12-29 |
| WO2020172328A1 (en) | 2020-08-27 |
| CA3131879A1 (en) | 2020-08-27 |
| CN113710691A (zh) | 2021-11-26 |
| CN113710691B (zh) | 2025-03-04 |
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