JP7547215B2 - テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 - Google Patents
テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 Download PDFInfo
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- JP7547215B2 JP7547215B2 JP2020566737A JP2020566737A JP7547215B2 JP 7547215 B2 JP7547215 B2 JP 7547215B2 JP 2020566737 A JP2020566737 A JP 2020566737A JP 2020566737 A JP2020566737 A JP 2020566737A JP 7547215 B2 JP7547215 B2 JP 7547215B2
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| JP2024146283A JP7855033B2 (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| US201862677926P | 2018-05-30 | 2018-05-30 | |
| US62/677,926 | 2018-05-30 | ||
| US201862771397P | 2018-11-26 | 2018-11-26 | |
| US62/771,397 | 2018-11-26 | ||
| US201962822365P | 2019-03-22 | 2019-03-22 | |
| US62/822,365 | 2019-03-22 | ||
| GC201937662 | 2019-05-28 | ||
| GC2019-37662 | 2019-05-28 | ||
| PCT/US2019/034515 WO2019232126A1 (en) | 2018-05-30 | 2019-05-30 | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
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| JP2024146283A Division JP7855033B2 (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| JP2021525746A5 JP2021525746A5 (cg-RX-API-DMAC10.html) | 2022-06-03 |
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| JP2020566737A Active JP7547215B2 (ja) | 2018-05-30 | 2019-05-30 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
| JP2024146283A Active JP7855033B2 (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110312721A (zh) | 2016-11-29 | 2019-10-08 | 显莎制药公司 | 墨蝶呤的多晶型物 |
| WO2018102315A1 (en) | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymoprhs of sepiapterin and salts thereof |
| MX2020002271A (es) | 2017-09-01 | 2020-10-05 | Ptc Therapeutics Mp Inc | Composiciones farmaceuticas que comprenden sepiapterina y sus usos de las mismas. |
| CA3102105A1 (en) | 2018-05-30 | 2019-12-05 | Ptc Therapeutics Mp, Inc. | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
| JP7778477B2 (ja) | 2018-05-30 | 2025-12-02 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンの薬学的に許容される塩 |
| JP7502197B2 (ja) * | 2018-05-30 | 2024-06-18 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリン血漿曝露を増加させるための方法 |
| LT4009978T (lt) | 2019-08-05 | 2024-11-25 | Ptc Therapeutics Mp, Inc. | Sepiapterino ir jo metabolitų panaudojimas spinduliuotės poveikio gydymui |
| CA3165636A1 (en) * | 2020-01-24 | 2021-07-29 | Neil Smith | Methods for treating parkinson's disease with sepiapterin |
| US12691119B2 (en) | 2021-02-09 | 2026-07-28 | Ptc Therapeutics Mp, Inc. | Methods for treating covid-19 with sepiapterin |
| US12298026B1 (en) | 2021-04-12 | 2025-05-13 | W. L. Gore & Associates, Inc. | Latent energy transfer laminate for plate pack core |
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| CA3102105A1 (en) | 2018-05-30 | 2019-12-05 | Ptc Therapeutics Mp, Inc. | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
| JP7502197B2 (ja) | 2018-05-30 | 2024-06-18 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリン血漿曝露を増加させるための方法 |
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2019
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Patent Citations (3)
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|---|---|---|---|---|
| JP2010523708A (ja) | 2007-04-11 | 2010-07-15 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
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| 医薬品の臨床薬物動態試験について，医薬審発第七九六号，各都道府県衛生主管部（局）長あて厚生労働省医薬局審査管理課長通知，2001年06月01日 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3102105A1 (en) | 2019-12-05 |
| EP4748370A2 (en) | 2026-05-27 |
| PL3801534T3 (pl) | 2026-07-06 |
| FR26C1028I1 (fr) | 2026-07-17 |
| JP2021525746A (ja) | 2021-09-27 |
| EP4748370A3 (en) | 2026-07-29 |
| ES3068414T3 (en) | 2026-05-29 |
| EP3801534A1 (en) | 2021-04-14 |
| SMT202600220T1 (it) | 2026-07-16 |
| JP7855033B2 (ja) | 2026-05-07 |
| US20210161901A1 (en) | 2021-06-03 |
| SI3801534T1 (sl) | 2026-06-30 |
| LTPA2026521I1 (cg-RX-API-DMAC10.html) | 2026-06-10 |
| US20250195529A1 (en) | 2025-06-19 |
| JP2024178188A (ja) | 2024-12-24 |
| NO2026028I1 (no) | 2026-05-29 |
| MX2020012980A (es) | 2021-04-29 |
| CN112654356A (zh) | 2021-04-13 |
| FI3801534T3 (fi) | 2026-04-14 |
| LT3801534T (lt) | 2026-05-25 |
| NL301382I2 (nl) | 2026-07-16 |
| EP3801534B1 (en) | 2026-02-18 |
| MD3801534T2 (en) | 2026-07-31 |
| US12257252B2 (en) | 2025-03-25 |
| EP3801534A4 (en) | 2022-03-16 |
| WO2019232126A1 (en) | 2019-12-05 |
| RS68045B1 (sr) | 2026-05-29 |
| HRP20260360T1 (hr) | 2026-06-05 |
| DK3801534T3 (da) | 2026-03-30 |
| BR112020024329A2 (pt) | 2021-02-23 |
| PT3801534T (pt) | 2026-04-28 |
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