JP7545726B2 - ｔＲＮＡ／プレｍｉＲＮＡ組成物およびがん治療における使用 - Google Patents

ｔＲＮＡ／プレｍｉＲＮＡ組成物およびがん治療における使用 Download PDF

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JP7545726B2
JP7545726B2 JP2020564923A JP2020564923A JP7545726B2 JP 7545726 B2 JP7545726 B2 JP 7545726B2 JP 2020564923 A JP2020564923 A JP 2020564923A JP 2020564923 A JP2020564923 A JP 2020564923A JP 7545726 B2 JP7545726 B2 JP 7545726B2
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mir
hsa
rna
trna
polynucleotide
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JP2021524245A5 (https=
JP2021524245A (ja
JPWO2019226603A5 (https=
Inventor
エイミン ユ、
プイ ヤン ホ、
メイジャン ツ、
ジョセフ エル． ジレク、
キャンユ ツァン、
ハンナ イー． ペトレク、
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/16—Aptamers
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3519—Fusion with another nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020564923A 2018-05-22 2019-05-21 ｔＲＮＡ／プレｍｉＲＮＡ組成物およびがん治療における使用 Active JP7545726B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862674939P 2018-05-22 2018-05-22
US62/674,939 2018-05-22
PCT/US2019/033232 WO2019226603A1 (en) 2018-05-22 2019-05-21 Trna/pre-mirna compositions and use in treating cancer

Publications (4)

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JP2021524245A JP2021524245A (ja) 2021-09-13
JP2021524245A5 JP2021524245A5 (https=) 2022-05-23
JPWO2019226603A5 JPWO2019226603A5 (https=) 2022-05-23
JP7545726B2 true JP7545726B2 (ja) 2024-09-05

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US (1) US11946049B2 (https=)
EP (1) EP3796920A4 (https=)
JP (1) JP7545726B2 (https=)
WO (1) WO2019226603A1 (https=)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
US11702657B2 (en) 2018-04-20 2023-07-18 The Regents Of The University Of California TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma
GB201919021D0 (en) 2019-12-20 2020-02-05 Reneuron Ltd Nucleic acid constructs for delivering polynucleotides into exosomes
CN110946872B (zh) * 2019-12-30 2022-11-04 北京大学深圳医院 miR-4491在制备治疗乳腺癌的药物中的应用
AU2021255583A1 (en) * 2020-04-14 2022-11-10 Flagship Pioneering Innovations Vi, Llc Trem compositions and uses thereof
CN114058697B (zh) * 2020-07-29 2023-08-18 四川大学华西医院 检测外泌体miR-6774-3p或miR-6776-5p的试剂的用途
US20230407297A1 (en) * 2020-11-03 2023-12-21 The Regents Of The University Of California Bioengineered wnt5a therapeutics for advanced cancers
WO2023164285A1 (en) * 2022-02-28 2023-08-31 Northwestern University DISE-INDUCING sRNA-POLYPLEXES AND sRNA-LIPOPOLYPLEXES AND METHODS OF USING THE SAME TO TREAT CANCER
CN115323057A (zh) * 2022-09-01 2022-11-11 浙江医院 肺癌治疗疗效相关的生物标志物
CN115896295A (zh) * 2022-12-30 2023-04-04 中国科学技术大学 辅助诊断胆囊炎或预测胆囊炎合并肝损伤的miRNA标志物
CN117126938A (zh) * 2023-10-08 2023-11-28 常州市第一人民医院 一种用于诊断膜性肾病的生物标志物及其应用方法
WO2025155837A1 (en) * 2024-01-19 2025-07-24 Massachusetts Institute Of Technology Modular microrna expression from self-replicating rna (replicons)
CN121406635A (zh) * 2024-05-08 2026-01-27 西安艾领克生物科技有限公司 一种利用活性tRNA在大肠杆菌中嵌合表达重组小RNA的方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015523856A (ja) 2012-05-25 2015-08-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフ Ｒｎａ依存性標的ｄｎａ修飾およびｒｎａ依存性転写調節のための方法および組成物
JP2016533760A (ja) 2013-09-06 2016-11-04 プレジデント アンド フェローズ オブ ハーバード カレッジ スイッチ可能ｃａｓ９ヌクレアーゼおよびその使用
JP2017524341A (ja) 2014-05-28 2017-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法

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WO2016153880A2 (en) * 2015-03-23 2016-09-29 The Regents Of The University Of California Methods for detection of rnase activity
US11702657B2 (en) * 2018-04-20 2023-07-18 The Regents Of The University Of California TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015523856A (ja) 2012-05-25 2015-08-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフ Ｒｎａ依存性標的ｄｎａ修飾およびｒｎａ依存性転写調節のための方法および組成物
JP2016533760A (ja) 2013-09-06 2016-11-04 プレジデント アンド フェローズ オブ ハーバード カレッジ スイッチ可能ｃａｓ９ヌクレアーゼおよびその使用
JP2017524341A (ja) 2014-05-28 2017-08-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ハイブリッドｔＲＮＡ／プレｍｉＲＮＡ分子および使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Pharmacol. Exp. Ther.，Vol.365，p.494-506，Epub 2018.03.30

Also Published As

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WO2019226603A1 (en) 2019-11-28
EP3796920A1 (en) 2021-03-31
EP3796920A4 (en) 2023-03-01
US20210246446A1 (en) 2021-08-12
US11946049B2 (en) 2024-04-02
JP2021524245A (ja) 2021-09-13

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