JP7539374B2 - ボロン酸ポリマーおよび使用方法 - Google Patents

ボロン酸ポリマーおよび使用方法 Download PDF

Info

Publication number
JP7539374B2
JP7539374B2 JP2021516652A JP2021516652A JP7539374B2 JP 7539374 B2 JP7539374 B2 JP 7539374B2 JP 2021516652 A JP2021516652 A JP 2021516652A JP 2021516652 A JP2021516652 A JP 2021516652A JP 7539374 B2 JP7539374 B2 JP 7539374B2
Authority
JP
Japan
Prior art keywords
polymer
pharmaceutical composition
cationic polymer
solution
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021516652A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022501483A (ja
JPWO2020061430A5 (https=
JP2022501483A5 (https=
Inventor
トーマス ヘンリー ジョゼフィアック，
アシシュ ニムガオンカー，
スティーブン シー． ポロモスカニク，
Original Assignee
グライセンド， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グライセンド， インコーポレイテッド filed Critical グライセンド， インコーポレイテッド
Publication of JP2022501483A publication Critical patent/JP2022501483A/ja
Priority to JP2024073800A priority Critical patent/JP2024096280A/ja
Publication of JPWO2020061430A5 publication Critical patent/JPWO2020061430A5/ja
Publication of JP2022501483A5 publication Critical patent/JP2022501483A5/ja
Application granted granted Critical
Publication of JP7539374B2 publication Critical patent/JP7539374B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L43/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
    • C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
    • C08F230/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing boron

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
JP2021516652A 2018-09-20 2019-09-20 ボロン酸ポリマーおよび使用方法 Active JP7539374B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024073800A JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862734054P 2018-09-20 2018-09-20
US62/734,054 2018-09-20
PCT/US2019/052110 WO2020061430A1 (en) 2018-09-20 2019-09-20 Boronic acid polymers and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024073800A Division JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Publications (4)

Publication Number Publication Date
JP2022501483A JP2022501483A (ja) 2022-01-06
JPWO2020061430A5 JPWO2020061430A5 (https=) 2024-05-15
JP2022501483A5 JP2022501483A5 (https=) 2024-05-15
JP7539374B2 true JP7539374B2 (ja) 2024-08-23

Family

ID=69887916

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021516652A Active JP7539374B2 (ja) 2018-09-20 2019-09-20 ボロン酸ポリマーおよび使用方法
JP2024073800A Pending JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024073800A Pending JP2024096280A (ja) 2018-09-20 2024-04-30 ボロン酸ポリマーおよび使用方法

Country Status (4)

Country Link
US (1) US20210403625A1 (https=)
EP (1) EP3852768A4 (https=)
JP (2) JP7539374B2 (https=)
WO (1) WO2020061430A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220233583A1 (en) * 2019-06-06 2022-07-28 Shanghai Jiaotong University Method for treating or preventing saccharide-related diseases or disorders
WO2021055759A1 (en) 2019-09-20 2021-03-25 Glyscend, Inc. Substituted phenyl boronic acid containing polymers and methods of use
CN116333197A (zh) * 2023-04-12 2023-06-27 厦门君德医药科技有限公司 胃肠道粘膜性聚合物、组合物及制备方法和应用
WO2026053928A1 (ja) * 2024-09-03 2026-03-12 株式会社シード 重合性ボロン酸化合物及び重合性カチオン性化合物を構成単位として含む高分子化合物及びその利用
CN120005104B (zh) * 2025-01-23 2025-10-31 武汉理工大学 一种pH响应型聚氨酯纳米材料、药物递送系统及制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134062A1 (en) 2002-11-19 2006-06-22 Huval Chad C Polymeric boronic acid derivatives as lipase inhibitors
WO2009066746A1 (ja) 2007-11-22 2009-05-28 The University Of Tokyo 組織癒着防止材および関節拘縮防止材
JP2016209372A (ja) 2015-05-11 2016-12-15 国立大学法人 東京医科歯科大学 インスリン送達用デバイス

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310844A (ja) * 1992-05-08 1993-11-22 Nippon Oil & Fats Co Ltd フェニルボロン酸基含有重合体
JPH07304971A (ja) * 1994-05-09 1995-11-21 Nippon Oil & Fats Co Ltd 糖応答性高分子材料
JP3867400B2 (ja) * 1998-05-08 2007-01-10 日本油脂株式会社 ボロン酸基含有単量体およびその重合体
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7662360B2 (en) * 2002-07-22 2010-02-16 Psimei Pharmaceuticals Plc Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds
WO2011106542A2 (en) * 2010-02-24 2011-09-01 Relypsa, Inc. Crosslinked polyvrnylamine, poly all ylamine, and polyethyleneimine for use as bile acid sequestrants
US9730637B2 (en) * 2011-08-19 2017-08-15 The Regents Of The University Of California Layered particles for retrieving DNA released from cells from a gastrointestinal tract sample and methods for making and using them
WO2017024237A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Composition and method for treatment of metabolic disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134062A1 (en) 2002-11-19 2006-06-22 Huval Chad C Polymeric boronic acid derivatives as lipase inhibitors
WO2009066746A1 (ja) 2007-11-22 2009-05-28 The University Of Tokyo 組織癒着防止材および関節拘縮防止材
JP2016209372A (ja) 2015-05-11 2016-12-15 国立大学法人 東京医科歯科大学 インスリン送達用デバイス

Also Published As

Publication number Publication date
JP2022501483A (ja) 2022-01-06
EP3852768A1 (en) 2021-07-28
EP3852768A4 (en) 2022-09-14
WO2020061430A1 (en) 2020-03-26
JP2024096280A (ja) 2024-07-12
US20210403625A1 (en) 2021-12-30

Similar Documents

Publication Publication Date Title
JP7539374B2 (ja) ボロン酸ポリマーおよび使用方法
JP2025019142A (ja) ベンゾオキサボロールポリマーおよび使用方法
JP2025168413A (ja) 置換フェニルボロン酸含有ポリマーおよび使用方法
US10905711B2 (en) Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
KR101547925B1 (ko) 아민 중합체에 대한 샤셋 제형
HU229292B1 (en) New pharmaceutical composition
CN101321519A (zh) 制备含有交联壳的核-壳型复合物的方法及其得到的核-壳型复合物
BRPI0209134B1 (pt) uso de um sevelamer ou um sal do mesmo e uso de um colesevelam ou um sal do mesmo
US20050239901A1 (en) Crosslinked amine polymers
US20150011645A1 (en) Amine dendrimers
US20080107737A1 (en) Crosslinked Amine Polymers
CN104204082B (zh) 高分子化氮氧化合物与无机颗粒的有机-无机杂合复合物
Fujii et al. Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form
HK1106133B (en) Ion binding compositions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220920

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220920

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20231025

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20231027

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20240321

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20240430

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240501

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240726

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240813

R150 Certificate of patent or registration of utility model

Ref document number: 7539374

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150