JP7514078B2 - 新規な組成物、組み合わせ及びその方法を用いた標的薬物救済 - Google Patents

新規な組成物、組み合わせ及びその方法を用いた標的薬物救済 Download PDF

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JP7514078B2
JP7514078B2 JP2019560216A JP2019560216A JP7514078B2 JP 7514078 B2 JP7514078 B2 JP 7514078B2 JP 2019560216 A JP2019560216 A JP 2019560216A JP 2019560216 A JP2019560216 A JP 2019560216A JP 7514078 B2 JP7514078 B2 JP 7514078B2
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formula
propan
phenoxy
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JP2020518617A (ja
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ヴェパチェドゥ,シュリーニヴァーサラオ
ジェイ. メビウス,ハンス
ベスパーロフ,アントン
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019560216A 2017-05-04 2018-05-03 新規な組成物、組み合わせ及びその方法を用いた標的薬物救済 Active JP7514078B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023119151A JP2023143940A (ja) 2017-05-04 2023-07-21 新規な組成物、組み合わせ及びその方法を用いた標的薬物救済

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201762501696P 2017-05-04 2017-05-04
US62/501,696 2017-05-04
PCT/US2017/048748 WO2018039642A1 (en) 2016-08-26 2017-08-25 Compositions and methods thereof
USPCT/US2017/048748 2017-08-25
TW106129169 2017-08-28
TW106129169A TW201815387A (zh) 2016-08-26 2017-08-28 組成物及其方法
US201862634162P 2018-02-22 2018-02-22
US62/634,162 2018-02-22
US201862636099P 2018-02-27 2018-02-27
US201862635554P 2018-02-27 2018-02-27
US62/635,554 2018-02-27
US62/636,099 2018-02-27
US201862636171P 2018-02-28 2018-02-28
US62/636,171 2018-02-28
PCT/US2018/030978 WO2018204713A1 (en) 2017-05-04 2018-05-03 Targeted drug rescue with novel compositions, combinations, and methods thereof

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JP2023119151A Division JP2023143940A (ja) 2017-05-04 2023-07-21 新規な組成物、組み合わせ及びその方法を用いた標的薬物救済

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JP2020518617A JP2020518617A (ja) 2020-06-25
JP7514078B2 true JP7514078B2 (ja) 2024-07-10

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JP2023119151A Pending JP2023143940A (ja) 2017-05-04 2023-07-21 新規な組成物、組み合わせ及びその方法を用いた標的薬物救済

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EP (1) EP3618819A4 (enrdf_load_stackoverflow)
JP (2) JP7514078B2 (enrdf_load_stackoverflow)
KR (2) KR102444803B1 (enrdf_load_stackoverflow)
CN (1) CN110831584B (enrdf_load_stackoverflow)
AU (2) AU2018261654A1 (enrdf_load_stackoverflow)
BR (1) BR112019022902A2 (enrdf_load_stackoverflow)
CA (2) CA3062452C (enrdf_load_stackoverflow)
IL (1) IL270326B2 (enrdf_load_stackoverflow)
MA (1) MA49464A (enrdf_load_stackoverflow)
RU (1) RU2760558C9 (enrdf_load_stackoverflow)
TW (1) TWI787260B (enrdf_load_stackoverflow)
WO (1) WO2018204713A1 (enrdf_load_stackoverflow)
ZA (1) ZA201908006B (enrdf_load_stackoverflow)

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WO2018204713A1 (en) * 2017-05-04 2018-11-08 Exciva Ug (Haftungsbeschränkt) Targeted drug rescue with novel compositions, combinations, and methods thereof
BR112021018564A2 (pt) * 2019-03-18 2021-11-30 Avanir Pharmaceuticals Inc Métodos de tratamento de sintomas negativos de esquizofrenia usando dextrometorfano deuterado e quinidina
JP7400818B2 (ja) * 2019-06-06 2023-12-19 Jsr株式会社 感放射線性樹脂組成物、レジストパターン形成方法及び化合物
CA3177454A1 (en) 2020-05-19 2021-11-25 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
CN116473077B (zh) * 2023-05-08 2025-04-11 广东方中高新材料有限公司 一种n,n配位的镓配合物抗菌剂的合成和应用
CN116473073A (zh) * 2023-05-08 2023-07-25 广东方中高新材料有限公司 一种含镓配合物的吡唑醚菌酯增效悬浮制剂及其制备方法

Citations (6)

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JP2000508341A (ja) 1996-10-09 2000-07-04 アルゴス ファーマシューティカル コーポレーション 片頭痛の治療法及び薬効の強化組成物
JP2003518063A (ja) 1999-12-22 2003-06-03 スミス,リチャード・アラン 麻薬および抗鬱剤から患者を離脱させるためのデキストロメトルファンおよびオキシダーゼ阻害剤の用法
JP2005537268A (ja) 2002-07-17 2005-12-08 アバニール・ファーマシューティカルズ 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物
JP2009525343A (ja) 2006-02-03 2009-07-09 アバニール・ファーマシューティカルズ 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物
JP2016510762A (ja) 2013-03-07 2016-04-11 マインドラブ・エルエルシー 鎮痛薬の組合せおよびその使用
JP2016516202A (ja) 2013-03-15 2016-06-02 キネメッド, インコーポレイテッド バイオマーカー

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US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4950658A (en) * 1988-12-06 1990-08-21 Board Of Trustees Of Southern Illinois Univ. Method of medical treatment of Alzheimer's disease
US6335371B1 (en) * 2000-11-28 2002-01-01 Orion Corporation Method for inducing cognition enhancement
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
NZ582124A (en) * 2007-05-21 2012-07-27 Reviva Pharmaceuticals Inc Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents
US8017623B2 (en) * 2008-07-03 2011-09-13 Trinity Laboratories, Inc. Dextromethorphan hydrochloride
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EP3708168A3 (en) * 2014-09-14 2020-12-09 Avanir Pharmaceuticals, Inc. Combinations of deuterated dextromethorphan and quinidine for the treatment of agitation in dementia
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JP2000508341A (ja) 1996-10-09 2000-07-04 アルゴス ファーマシューティカル コーポレーション 片頭痛の治療法及び薬効の強化組成物
JP2003518063A (ja) 1999-12-22 2003-06-03 スミス,リチャード・アラン 麻薬および抗鬱剤から患者を離脱させるためのデキストロメトルファンおよびオキシダーゼ阻害剤の用法
JP2005537268A (ja) 2002-07-17 2005-12-08 アバニール・ファーマシューティカルズ 神経疾患治療のためのデキストロメトルファンおよびキニジンを含む薬剤組成物
JP2009525343A (ja) 2006-02-03 2009-07-09 アバニール・ファーマシューティカルズ 鬱病、不安および神経変性疾患を治療するためのデキストロメトルファンおよびキニジンを含む薬剤組成物
JP2016510762A (ja) 2013-03-07 2016-04-11 マインドラブ・エルエルシー 鎮痛薬の組合せおよびその使用
JP2016516202A (ja) 2013-03-15 2016-06-02 キネメッド, インコーポレイテッド バイオマーカー

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Publication number Publication date
IL270326B (en) 2022-10-01
ZA201908006B (en) 2021-04-28
EP3618819A1 (en) 2020-03-11
CA3062452C (en) 2023-10-24
CA3138116A1 (en) 2018-11-08
JP2020518617A (ja) 2020-06-25
IL270326A (enrdf_load_stackoverflow) 2018-05-03
KR20200062078A (ko) 2020-06-03
CN110831584B (zh) 2023-03-10
CA3062452A1 (en) 2018-11-08
AU2018261654A1 (en) 2019-11-14
RU2019137004A3 (enrdf_load_stackoverflow) 2021-06-04
RU2019137004A (ru) 2021-06-04
RU2760558C2 (ru) 2021-11-29
IL270326B2 (en) 2023-02-01
RU2760558C9 (ru) 2022-02-22
AU2021215274B2 (en) 2022-11-03
JP2023143940A (ja) 2023-10-06
MA49464A (fr) 2020-04-29
BR112019022902A2 (pt) 2020-05-19
TW201842902A (zh) 2018-12-16
CN110831584A (zh) 2020-02-21
KR20210130827A (ko) 2021-11-01
WO2018204713A1 (en) 2018-11-08
EP3618819A4 (en) 2021-01-20
TWI787260B (zh) 2022-12-21
AU2021215274A1 (en) 2021-09-02
KR102444803B1 (ko) 2022-09-19

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