JP7513604B2 - 皮膚がんを治療するためのｐｄ－１阻害剤の病変内投与 - Google Patents

皮膚がんを治療するためのｐｄ－１阻害剤の病変内投与 Download PDF

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JP7513604B2
JP7513604B2 JP2021526256A JP2021526256A JP7513604B2 JP 7513604 B2 JP7513604 B2 JP 7513604B2 JP 2021526256 A JP2021526256 A JP 2021526256A JP 2021526256 A JP2021526256 A JP 2021526256A JP 7513604 B2 JP7513604 B2 JP 7513604B2
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amino acid
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マシュー・ジー・フュリー
イザレル・ロウィ
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Regeneron Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
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JP2021526256A 2018-11-14 2019-11-13 皮膚がんを治療するためのｐｄ－１阻害剤の病変内投与 Active JP7513604B2 (ja)

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JP2024102591A JP2024123216A (ja) 2018-11-14 2024-06-26 皮膚がんを治療するためのｐｄ－１阻害剤の病変内投与

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US201862767218P 2018-11-14 2018-11-14
US62/767,218 2018-11-14
PCT/US2019/061212 WO2020102375A1 (en) 2018-11-14 2019-11-13 Intralesional administration of pd-1 inhibitors for treating skin cancer

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JP2022513029A JP2022513029A (ja) 2022-02-07
JPWO2020102375A5 JPWO2020102375A5 (https=) 2022-11-07
JP2022513029A5 JP2022513029A5 (https=) 2022-11-07
JP7513604B2 true JP7513604B2 (ja) 2024-07-09

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JP2024102591A Pending JP2024123216A (ja) 2018-11-14 2024-06-26 皮膚がんを治療するためのｐｄ－１阻害剤の病変内投与

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US (2) US12473364B2 (https=)
EP (2) EP3880186B1 (https=)
JP (2) JP7513604B2 (https=)
CN (1) CN113038939A (https=)
DK (1) DK3880186T3 (https=)
ES (1) ES2980363T3 (https=)
FI (1) FI3880186T3 (https=)
HR (1) HRP20240825T1 (https=)
HU (1) HUE067601T2 (https=)
LT (1) LT3880186T (https=)
PL (1) PL3880186T3 (https=)
PT (1) PT3880186T (https=)
RS (1) RS65627B1 (https=)
SI (1) SI3880186T1 (https=)
SM (1) SMT202400252T1 (https=)
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TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
JP7126941B2 (ja) 2015-12-22 2022-08-29 リジェネロン・ファーマシューティカルズ・インコーポレイテッド がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ
EP4313123A1 (en) * 2021-03-23 2024-02-07 Regeneron Pharmaceuticals, Inc. Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor

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EP4382168A3 (en) 2024-08-28
US12473364B2 (en) 2025-11-18
WO2020102375A1 (en) 2020-05-22
US20210388091A1 (en) 2021-12-16
JP2022513029A (ja) 2022-02-07
EP3880186A1 (en) 2021-09-22
FI3880186T3 (fi) 2024-05-30
US20260042841A1 (en) 2026-02-12
EP4382168A2 (en) 2024-06-12
JP2024123216A (ja) 2024-09-10
DK3880186T3 (da) 2024-06-03
SMT202400252T1 (it) 2024-07-09
PL3880186T3 (pl) 2024-07-22
CN113038939A (zh) 2021-06-25
SI3880186T1 (sl) 2024-07-31
HRP20240825T1 (hr) 2024-09-27
RS65627B1 (sr) 2024-07-31
LT3880186T (lt) 2024-06-10
PT3880186T (pt) 2024-05-28
HUE067601T2 (hu) 2024-10-28
EP3880186B1 (en) 2024-04-03
ES2980363T3 (es) 2024-10-01

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