JP7512272B2 - Ａｌｋ２抗体及びその使用方法 - Google Patents

Ａｌｋ２抗体及びその使用方法 Download PDF

Info

Publication number
JP7512272B2
JP7512272B2 JP2021521976A JP2021521976A JP7512272B2 JP 7512272 B2 JP7512272 B2 JP 7512272B2 JP 2021521976 A JP2021521976 A JP 2021521976A JP 2021521976 A JP2021521976 A JP 2021521976A JP 7512272 B2 JP7512272 B2 JP 7512272B2
Authority
JP
Japan
Prior art keywords
seq
alk2
binding fragment
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021521976A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022505585A (ja
JP2022505585A5 (https=
Inventor
エス． シーラ、ジャスバー
ラシェイ、ジェニファー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keros Therapeutics Inc
Original Assignee
Keros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keros Therapeutics Inc filed Critical Keros Therapeutics Inc
Publication of JP2022505585A publication Critical patent/JP2022505585A/ja
Publication of JP2022505585A5 publication Critical patent/JP2022505585A5/ja
Priority to JP2024102779A priority Critical patent/JP2024114820A/ja
Application granted granted Critical
Publication of JP7512272B2 publication Critical patent/JP7512272B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021521976A 2018-10-23 2019-10-23 Ａｌｋ２抗体及びその使用方法 Active JP7512272B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024102779A JP2024114820A (ja) 2018-10-23 2024-06-26 Ａｌｋ２抗体及びその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862749463P 2018-10-23 2018-10-23
US62/749,463 2018-10-23
PCT/US2019/057679 WO2020086730A1 (en) 2018-10-23 2019-10-23 Alk2 antibodies and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024102779A Division JP2024114820A (ja) 2018-10-23 2024-06-26 Ａｌｋ２抗体及びその使用方法

Publications (3)

Publication Number Publication Date
JP2022505585A JP2022505585A (ja) 2022-01-14
JP2022505585A5 JP2022505585A5 (https=) 2022-10-18
JP7512272B2 true JP7512272B2 (ja) 2024-07-08

Family

ID=70331231

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021521976A Active JP7512272B2 (ja) 2018-10-23 2019-10-23 Ａｌｋ２抗体及びその使用方法
JP2024102779A Pending JP2024114820A (ja) 2018-10-23 2024-06-26 Ａｌｋ２抗体及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024102779A Pending JP2024114820A (ja) 2018-10-23 2024-06-26 Ａｌｋ２抗体及びその使用方法

Country Status (10)

Country Link
US (2) US12331124B2 (https=)
EP (1) EP3870613A4 (https=)
JP (2) JP7512272B2 (https=)
KR (1) KR102919834B1 (https=)
CN (2) CN113366019B (https=)
AU (1) AU2019364415A1 (https=)
BR (1) BR112021007660A2 (https=)
CA (1) CA3116900A1 (https=)
IL (1) IL282424A (https=)
WO (1) WO2020086730A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3870181B1 (en) 2018-10-26 2024-08-14 Keros Therapeutics, Inc. Crystal forms of an alk2 inhibitor
US20220372135A1 (en) 2019-09-27 2022-11-24 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
KR20220140802A (ko) 2020-02-11 2022-10-18 리제너론 파아마슈티컬스, 인크. 항-acvr1 항체 및 이의 용도
US12508262B2 (en) 2020-04-30 2025-12-30 Keros Therapeutics, Inc. Methods of using ALK2 inhibitors
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
US20250282877A1 (en) * 2021-05-11 2025-09-11 Keros Therapeutics, Inc. Methods of using alk2 and alk3 antibodies
US20250034148A1 (en) * 2021-11-02 2025-01-30 Keros Therapeutics, Inc. Methods of using alk2 inhibitors
WO2024092133A1 (en) * 2022-10-27 2024-05-02 Regeneron Pharmaceuticals, Inc. Anti-acvr1 antibodies and their use in the treatment of trauma-induced heterotopic ossification

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015152183A1 (ja) 2014-03-31 2015-10-08 大日本住友製薬株式会社 進行性骨化性線維異形成症の予防剤及び治療剤
WO2016121908A1 (ja) 2015-01-30 2016-08-04 学校法人埼玉医科大学 抗ａｌｋ２抗体
JP2017528476A (ja) 2014-09-12 2017-09-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 進行性骨化性線維異形成症の治療

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2570458C (en) * 2004-06-09 2014-05-20 Technion Research & Development Foundation Ltd. Antibodies for selective apoptosis of cells
CA2662350A1 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
JP5755635B2 (ja) 2009-03-30 2015-07-29 アクセルロン ファーマ， インコーポレイテッド Ｂｍｐ−ａｌｋ３アンタゴニストおよび骨成長促進のためのその使用
WO2011116212A2 (en) 2010-03-17 2011-09-22 Oncomed Pharmaceuticals, Inc. Bone morphogenetic protein receptor binding agents and methods of their use
WO2012065059A2 (en) 2010-11-12 2012-05-18 The General Hospital Corporation Treatment of atherosclerosis with bmp-alk3 antagonists
WO2016154572A1 (en) * 2015-03-26 2016-09-29 Vanderbilt University Antibody-mediated neutralizaton of ebolaviruses
WO2020118011A1 (en) 2018-12-06 2020-06-11 Alexion Pharmaceuticals, Inc. Anti-alk2 antibodies and uses thereof
KR20220140802A (ko) 2020-02-11 2022-10-18 리제너론 파아마슈티컬스, 인크. 항-acvr1 항체 및 이의 용도
WO2021257532A1 (en) 2020-06-16 2021-12-23 Incyte Corporation Alk2 inhibitors for the treatment of anemia
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload
WO2022098821A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating lymphopenia
WO2022099166A1 (en) 2020-11-09 2022-05-12 Keros Therapeutics, Inc. Methods of treating cardiovascular-related disease
US20250282877A1 (en) 2021-05-11 2025-09-11 Keros Therapeutics, Inc. Methods of using alk2 and alk3 antibodies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015152183A1 (ja) 2014-03-31 2015-10-08 大日本住友製薬株式会社 進行性骨化性線維異形成症の予防剤及び治療剤
JP2017528476A (ja) 2014-09-12 2017-09-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 進行性骨化性線維異形成症の治療
WO2016121908A1 (ja) 2015-01-30 2016-08-04 学校法人埼玉医科大学 抗ａｌｋ２抗体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Takenobu Katagiri et al.，Development of blocking monoclonal antibodies against ALK2, which is a type I receptor for BMPs，2017 Annual Meeting of the American Society for Bone and Mineral Research, 2017 Abstracts，2017年，Vol. 32, Issue S1，p.S33, Number 1094

Also Published As

Publication number Publication date
JP2022505585A (ja) 2022-01-14
US20250270333A1 (en) 2025-08-28
CA3116900A1 (en) 2020-04-30
WO2020086730A1 (en) 2020-04-30
EP3870613A1 (en) 2021-09-01
EP3870613A4 (en) 2022-08-03
CN113366019A (zh) 2021-09-07
BR112021007660A2 (pt) 2021-08-03
JP2024114820A (ja) 2024-08-23
CN113366019B (zh) 2024-08-27
IL282424A (en) 2021-06-30
CN118955715A (zh) 2024-11-15
KR102919834B1 (ko) 2026-01-30
US12331124B2 (en) 2025-06-17
AU2019364415A1 (en) 2021-05-20
KR20210088591A (ko) 2021-07-14
US20210253720A1 (en) 2021-08-19

Similar Documents

Publication Publication Date Title
JP7512272B2 (ja) Ａｌｋ２抗体及びその使用方法
JP7757439B2 (ja) アクチビンｉｉｂ型受容体変異体を含むポリペプチドおよび医薬組成物
US12522646B2 (en) Activin receptor type II chimeras and methods of use thereof
US20230372390A1 (en) Methods of treating lymphopenia
US20250270287A1 (en) Activin receptor type ii chimeras and methods of use thereof
US20250282877A1 (en) Methods of using alk2 and alk3 antibodies
US20240228583A1 (en) Activin receptor type ii chimeras and methods of use thereof
CA3153062A1 (en) Treatment of liver disease or disorder comprising actrii receptor antagonists
HK40119616A (zh) Alk2抗体及其使用方法
HK40127518A (zh) 激活素受体iib型变体及其使用方法
WO2010046474A2 (en) Chemoattractants inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221007

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20221007

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230919

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230920

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20231219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240313

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20240528

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20240626