JP7510165B2 - 試験器 - Google Patents
試験器 Download PDFInfo
- Publication number
- JP7510165B2 JP7510165B2 JP2020170253A JP2020170253A JP7510165B2 JP 7510165 B2 JP7510165 B2 JP 7510165B2 JP 2020170253 A JP2020170253 A JP 2020170253A JP 2020170253 A JP2020170253 A JP 2020170253A JP 7510165 B2 JP7510165 B2 JP 7510165B2
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- Japan
- Prior art keywords
- test
- float plate
- liquid
- tester
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000012360 testing method Methods 0.000 title claims description 124
- 239000007788 liquid Substances 0.000 claims description 43
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 20
- 239000007853 buffer solution Substances 0.000 claims description 19
- 238000009472 formulation Methods 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 19
- 238000007922 dissolution test Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 238000003756 stirring Methods 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 229920006327 polystyrene foam Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Images
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
項1.
試験液中の製剤を試験するための試験器であって、
試験液を収容するための試験容器を含み、
前記試験容器がフロート板を有する、試験器。
項2.
前記フロート板は平板形状を有し、前記試験器使用時において前記試験液面の90%以上を被覆する、請求項1に記載の試験器。
項3.
前記フロート板は樹脂製である、請求項1又は2に記載の試験器。
項4.
前記製剤試験が、崩壊試験又は溶出試験である、請求項1~3の何れか1項に記載の試験器。
項5.
フロート板を試験液の液面に浮遊させて試験を実施する工程を含む、製剤試験法。
2 試験容器
3 攪拌装置
31 回転軸
32 攪拌翼
4 pHメーター
A 試験対象の製剤(薬剤)
B フロート板
Claims (4)
- 試験液中の製剤を試験するための試験器であって、
試験液を収容するための試験容器を含み、
前記試験容器がフロート板を有し、
前記試験が、崩壊試験又は溶出試験であり、
前記試験液が炭酸緩衝液である、試験器。 - 前記フロート板は平板形状を有し、前記試験器使用時において前記試験液面の90%以上を被覆する、請求項1に記載の試験器。
- 前記フロート板は樹脂製である、請求項1又は2に記載の試験器。
- フロート板を試験液の液面に浮遊させて試験を実施する工程を含む、製剤試験法であって、
該製剤試験が崩壊試験又は溶出試験であり、
前記試験液が炭酸緩衝液である、製剤試験法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020170253A JP7510165B2 (ja) | 2020-10-08 | 2020-10-08 | 試験器 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020170253A JP7510165B2 (ja) | 2020-10-08 | 2020-10-08 | 試験器 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022062327A JP2022062327A (ja) | 2022-04-20 |
JP7510165B2 true JP7510165B2 (ja) | 2024-07-03 |
Family
ID=81210877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020170253A Active JP7510165B2 (ja) | 2020-10-08 | 2020-10-08 | 試験器 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP7510165B2 (ja) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000214171A (ja) | 1999-01-20 | 2000-08-04 | Internatl Reagents Corp | 溶液安定化部材及び溶液の安定化方法 |
JP2006322744A (ja) | 2005-05-17 | 2006-11-30 | Jasco Corp | 溶出試験器 |
JP3144767U (ja) | 2008-06-30 | 2008-09-11 | 富山産業株式会社 | 溶出試験器 |
JP2009058322A (ja) | 2007-08-31 | 2009-03-19 | Hitachi High-Technologies Corp | 液体容器、及び自動分析装置 |
US20090207691A1 (en) | 2008-02-14 | 2009-08-20 | Varian, Inc. | Dissolution test vessel with rotational agitation |
JP2018054535A (ja) | 2016-09-30 | 2018-04-05 | 住鉱テクノリサーチ株式会社 | 溶液の分析方法 |
-
2020
- 2020-10-08 JP JP2020170253A patent/JP7510165B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000214171A (ja) | 1999-01-20 | 2000-08-04 | Internatl Reagents Corp | 溶液安定化部材及び溶液の安定化方法 |
JP2006322744A (ja) | 2005-05-17 | 2006-11-30 | Jasco Corp | 溶出試験器 |
JP2009058322A (ja) | 2007-08-31 | 2009-03-19 | Hitachi High-Technologies Corp | 液体容器、及び自動分析装置 |
US20090207691A1 (en) | 2008-02-14 | 2009-08-20 | Varian, Inc. | Dissolution test vessel with rotational agitation |
JP3144767U (ja) | 2008-06-30 | 2008-09-11 | 富山産業株式会社 | 溶出試験器 |
JP2018054535A (ja) | 2016-09-30 | 2018-04-05 | 住鉱テクノリサーチ株式会社 | 溶液の分析方法 |
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Publication number | Publication date |
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JP2022062327A (ja) | 2022-04-20 |
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