JP7500548B2 - 局所用組成物 - Google Patents
局所用組成物 Download PDFInfo
- Publication number
- JP7500548B2 JP7500548B2 JP2021514608A JP2021514608A JP7500548B2 JP 7500548 B2 JP7500548 B2 JP 7500548B2 JP 2021514608 A JP2021514608 A JP 2021514608A JP 2021514608 A JP2021514608 A JP 2021514608A JP 7500548 B2 JP7500548 B2 JP 7500548B2
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- JP
- Japan
- Prior art keywords
- peg
- weight
- emulsifier
- topical composition
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 102
- 230000000699 topical effect Effects 0.000 title claims description 52
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 51
- 239000003995 emulsifying agent Substances 0.000 claims description 49
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 40
- 239000011726 vitamin B6 Substances 0.000 claims description 34
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 33
- 235000019158 vitamin B6 Nutrition 0.000 claims description 33
- 229940011671 vitamin b6 Drugs 0.000 claims description 33
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 16
- 238000002845 discoloration Methods 0.000 claims description 15
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 15
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 15
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 15
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 13
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 12
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- 229940075529 glyceryl stearate Drugs 0.000 claims description 11
- 229940100460 peg-100 stearate Drugs 0.000 claims description 11
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- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 8
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- 239000012071 phase Substances 0.000 claims description 7
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 claims description 7
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 229960003581 pyridoxal Drugs 0.000 claims description 3
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- 239000011674 pyridoxal Substances 0.000 claims description 3
- 235000008151 pyridoxamine Nutrition 0.000 claims description 3
- 239000011699 pyridoxamine Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 30
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 19
- 239000002537 cosmetic Substances 0.000 description 19
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- 229920001577 copolymer Polymers 0.000 description 5
- ZUVCYFMOHFTGDM-UHFFFAOYSA-N hexadecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(O)=O ZUVCYFMOHFTGDM-UHFFFAOYSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
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- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 125000000129 anionic group Chemical group 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007957 coemulsifier Substances 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 150000002191 fatty alcohols Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 229940032067 peg-20 stearate Drugs 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000012049 topical pharmaceutical composition Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 description 2
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000195940 Bryophyta Species 0.000 description 2
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
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- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
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- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- OFUHPGMOWVHNPN-QWZFGMNQSA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] (9z,12z)-octadeca-9,12-dienoate Chemical group O1[C@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CCC2=C(C)C(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)=C(C)C(C)=C21 OFUHPGMOWVHNPN-QWZFGMNQSA-N 0.000 description 2
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Description
表1に概要を示す配合物を調製し、40℃で3ヵ月間保管した。参照用として、リン酸セチル乳化剤を含む同じ組成物を調製した。t0及び3ヵ月保管後の色安定性を、試料の変色の指標値であるb値(L*a*b*値/CIELAB系)(b値が高いほど変色が大きい)を測定することにより評価した。
表2及び3に概要を示す配合物を調製し、膳板の上で6週間保管した。PEG乳化剤に替えてリン酸セチル乳化剤を含むものを参照用とした。表2は、2重量%の乳化剤及び0.5重量%のビタミンB6を含む実施例の概要を示し、表3は、2重量%の乳化剤及び0.1重量%のビタミンB6を含む実施例の概要を示す。
さらなる実施形態は以下のとおりである。
[実施形態1]
ビタミンB6又はその誘導体を含む局所用組成物の変色を抑制するための、任意選択的にヒアルロン酸又はその塩と組み合わせたPEG乳化剤の使用。
[実施形態2]
前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、実施形態1に記載の使用。
[実施形態3]
前記PEG乳化剤は、任意選択的にステアリン酸グリセリルと組み合わせたステアリン酸PEG-100、ヤシ油脂肪酸PEG-20及び/又はステアレス-21である、実施形態1又は2に記載の使用。
[実施形態4]
ヒアルロン酸又はその塩は、存在し、前記ヒアルロン酸又はその塩は、ヒアルロン酸ナトリウムである、実施形態1~3のいずれか1つに記載の使用。
[実施形態5]
前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、実施形態1~4のいずれか1つに記載の使用。
[実施形態6]
前記PEG乳化剤の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、実施形態1~5のいずれか1つに記載の使用。
[実施形態7]
前記ヒアルロン酸又はその塩の量は、前記組成物の総重量を基準として0.01~5重量%の範囲、好ましくは0.02~3重量%の範囲、最も好ましくは0.05~2重量%の範囲において選択される、実施形態1~6のいずれか1つに記載の使用。
[実施形態8]
前記局所用組成物は、前記PEG乳化剤の存在下で水相中に分散された油性相を含むO/W型エマルジョンである、実施形態1~7のいずれか1つに記載の使用。
[実施形態9]
ビタミンB6又はその誘導体を含有する局所用組成物の変色を低減するための方法であって、ビタミンB6又はその誘導体、PEG乳化剤並びに任意選択的にヒアルロン酸又はその塩及び化粧的に許容される担体を含む局所用組成物を調製することを含む方法。
[実施形態10]
前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、実施形態9に記載の方法。
[実施形態11]
前記PEG乳化剤は、ステアリン酸グリセリルと組み合わせて使用されるステアリン酸PEG-100である、実施形態9又は10に記載の方法。
[実施形態12]
ヒアルロン酸又はその塩は、存在し、前記ヒアルロン酸又はその塩は、ヒアルロン酸ナトリウムである、実施形態9~11のいずれか1つに記載の方法。
[実施形態13]
前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、実施形態9~12のいずれか1つに記載の方法。
[実施形態14]
前記PEG乳化剤の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、実施形態9~13のいずれか1つに記載の方法。
[実施形態15]
前記ヒアルロン酸又はその塩の量は、前記組成物の総重量を基準として0.01~5重量%の範囲、好ましくは0.02~3重量%の範囲、最も好ましくは0.05~2重量%の範囲において選択される、実施形態9~14のいずれか1つに記載の方法。
Claims (15)
- ビタミンB6又はその誘導体を含む局所用組成物の変色を抑制するための、ヒアルロン酸ナトリウムと組み合わせたPEG乳化剤の使用であって、
前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩、ピリドキサール又はピリドキサミンであり、
前記PEG乳化剤は、ステアリン酸PEG-100、ヤシ油脂肪酸PEG-20及び/又はステアレス-21を含有し、
前記ヒアルロン酸ナトリウムの量は、前記局所用組成物の総重量を基準として0.01~5重量%である、使用。 - 前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、請求項1に記載の使用。
- 前記PEG乳化剤は、ヤシ油脂肪酸PEG-20、ステアレス-21、又は、ステアリン酸グリセリルと組み合わせたステアリン酸PEG-100である、請求項1又は2に記載の使用。
- 前記PEG乳化剤は、ヤシ油脂肪酸PEG-20又はステアレス-21である、請求項1又は2に記載の使用。
- 前記PEG乳化剤は、ヤシ油脂肪酸PEG-20である、請求項1又は2に記載の使用。
- 前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記局所用組成物の総重量を基準として0.02~6重量%である、請求項1~5のいずれか一項に記載の使用。
- 前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記局所用組成物の総重量を基準として0.02~0.1重量%である、請求項1~5のいずれか一項に記載の使用。
- 前記PEG乳化剤の量は、前記局所用組成物の総重量を基準として0.02~6重量%である、請求項1~7のいずれか一項に記載の使用。
- 前記局所用組成物は、前記PEG乳化剤の存在下で水相中に分散された油性相を含むO/W型エマルジョンである、請求項1~8のいずれか一項に記載の使用。
- ビタミンB6又はその誘導体を含有する局所用組成物の変色を低減するための方法であって、
ビタミンB6又はその誘導体、PEG乳化剤、ヒアルロン酸ナトリウム及び化粧的に許容される担体を含む局所用組成物を調製することを含み、
前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩、ピリドキサール又はピリドキサミンであり、
前記PEG乳化剤は、ステアリン酸PEG-100、ヤシ油脂肪酸PEG-20及び/又はステアレス-21を含有し、
前記ヒアルロン酸ナトリウムの量は、前記局所用組成物の総重量を基準として0.01~5重量%である、方法。 - 前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、請求項10に記載の方法。
- 前記PEG乳化剤は、ステアリン酸グリセリルと組み合わせて使用されるステアリン酸PEG-100である、請求項10又は11に記載の方法。
- 前記PEG乳化剤は、ヤシ油脂肪酸PEG-20又はステアレス-21である、請求項10又は11に記載の方法。
- 前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記局所用組成物の総重量を基準として0.02~6重量%である、請求項10~13のいずれか一項に記載の方法。
- 前記PEG乳化剤の量は、前記局所用組成物の総重量を基準として0.02~6重量%である、請求項10~14のいずれか一項に記載の方法。
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