JP2022503726A - 局所用組成物 - Google Patents
局所用組成物 Download PDFInfo
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- JP2022503726A JP2022503726A JP2021514608A JP2021514608A JP2022503726A JP 2022503726 A JP2022503726 A JP 2022503726A JP 2021514608 A JP2021514608 A JP 2021514608A JP 2021514608 A JP2021514608 A JP 2021514608A JP 2022503726 A JP2022503726 A JP 2022503726A
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- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 30
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Classifications
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A—HUMAN NECESSITIES
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Landscapes
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Abstract
【選択図】なし
Description
表1に概要を示す配合物を調製し、40℃で3ヵ月間保管した。参照用として、リン酸セチル乳化剤を含む同じ組成物を調製した。t0及び3ヵ月保管後の色安定性を、試料の変色の指標値であるb値(L*a*b*値/CIELAB系)(b値が高いほど変色が大きい)を測定することにより評価した。
表2及び3に概要を示す配合物を調製し、膳板の上で6週間保管した。PEG乳化剤に替えてリン酸セチル乳化剤を含むものを参照用とした。表2は、2重量%の乳化剤及び0.5重量%のビタミンB6を含む実施例の概要を示し、表3は、2重量%の乳化剤及び0.1重量%のビタミンB6を含む実施例の概要を示す。
Claims (15)
- ビタミンB6又はその誘導体を含む局所用組成物の変色を抑制するための、任意選択的にヒアルロン酸又はその塩と組み合わせたPEG乳化剤の使用。
- 前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、請求項1に記載の使用。
- 前記PEG乳化剤は、任意選択的にステアリン酸グリセリル、ヤシ油脂肪酸PEG-20及び/又はステアレス-21と組み合わせたステアリン酸PEG-100である、請求項1又は2に記載の使用。
- ヒアルロン酸又はその塩は、存在し、前記ヒアルロン酸又はその塩は、ヒアルロン酸ナトリウムである、請求項1~3のいずれか一項に記載の使用。
- 前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、請求項1~4のいずれか一項に記載の使用。
- 前記PEG乳化剤の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、請求項1~5のいずれか一項に記載の使用。
- 前記ヒアルロン酸又はその塩の量は、前記組成物の総重量を基準として0.01~5重量%の範囲、好ましくは0.02~3重量%の範囲、最も好ましくは0.05~2重量%の範囲において選択される、請求項1~6のいずれか一項に記載の使用。
- 前記局所用組成物は、前記PEG乳化剤の存在下で水相中に分散された油性相を含むO/W型エマルジョンである、請求項1~7のいずれか一項に記載の使用。
- ビタミンB6又はその誘導体を含有する局所用組成物の変色を低減するための方法であって、ビタミンB6又はその誘導体、PEG乳化剤並びに任意選択的にヒアルロン酸又はその塩及び化粧的に許容される担体を含む局所用組成物を調製することを含む方法。
- 前記ビタミンB6又はその誘導体は、ピリドキシン塩酸塩である、請求項9に記載の方法。
- 前記PEG乳化剤は、ステアリン酸グリセリルと組み合わせて使用されるステアリン酸PEG-100である、請求項9又は10に記載の方法。
- ヒアルロン酸又はその塩は、存在し、前記ヒアルロン酸又はその塩は、ヒアルロン酸ナトリウムである、請求項9~11のいずれか一項に記載の方法。
- 前記局所用組成物中の前記ビタミンB6又はその誘導体の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、請求項9~12のいずれか一項に記載の方法。
- 前記PEG乳化剤の量は、前記組成物の総重量を基準として0.02~6重量%の範囲、好ましくは0.05~4重量%の範囲、最も好ましくは0.1~3重量%の範囲において選択される、請求項9~13のいずれか一項に記載の方法。
- 前記ヒアルロン酸又はその塩の量は、前記組成物の総重量を基準として0.01~5重量%の範囲、好ましくは0.02~3重量%の範囲、最も好ましくは0.05~2重量%の範囲において選択される、請求項9~14のいずれか一項に記載の方法。
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