JP7495983B2 - Ｅｇｆｒ阻害剤 - Google Patents

Ｅｇｆｒ阻害剤 Download PDF

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Publication number
JP7495983B2
JP7495983B2 JP2022536419A JP2022536419A JP7495983B2 JP 7495983 B2 JP7495983 B2 JP 7495983B2 JP 2022536419 A JP2022536419 A JP 2022536419A JP 2022536419 A JP2022536419 A JP 2022536419A JP 7495983 B2 JP7495983 B2 JP 7495983B2
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Japan
Prior art keywords
group
alkyl group
compound
egfr
hydrogen atom
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JP2022536419A
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English (en)
Japanese (ja)
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JPWO2022014639A1 (enExample
JPWO2022014639A5 (enExample
Inventor
憩 小口
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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Publication of JPWO2022014639A1 publication Critical patent/JPWO2022014639A1/ja
Publication of JPWO2022014639A5 publication Critical patent/JPWO2022014639A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022536419A 2020-07-15 2021-07-14 Ｅｇｆｒ阻害剤 Active JP7495983B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020121525 2020-07-15
JP2020121525 2020-07-15
PCT/JP2021/026461 WO2022014639A1 (ja) 2020-07-15 2021-07-14 Ｅｇｆｒ阻害剤

Publications (3)

Publication Number Publication Date
JPWO2022014639A1 JPWO2022014639A1 (enExample) 2022-01-20
JPWO2022014639A5 JPWO2022014639A5 (enExample) 2023-03-27
JP7495983B2 true JP7495983B2 (ja) 2024-06-05

Family

ID=79554696

Family Applications (1)

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JP2022536419A Active JP7495983B2 (ja) 2020-07-15 2021-07-14 Ｅｇｆｒ阻害剤

Country Status (12)

Country Link
US (1) US20230285397A1 (enExample)
EP (1) EP4197538A4 (enExample)
JP (1) JP7495983B2 (enExample)
KR (1) KR102873219B1 (enExample)
CN (1) CN116368136B (enExample)
AU (1) AU2021309779B2 (enExample)
BR (1) BR112023000770A2 (enExample)
CA (1) CA3189460A1 (enExample)
MX (1) MX2023000693A (enExample)
PH (1) PH12023550119A1 (enExample)
TW (1) TW202216152A (enExample)
WO (1) WO2022014639A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022014638A1 (ja) * 2020-07-15 2022-01-20 大鵬薬品工業株式会社 ピリミジン化合物の結晶
AU2021308045B2 (en) * 2020-07-15 2024-06-20 Taiho Pharmaceutical Co., Ltd. Pyrimidine compound-containing combination to be used in tumor treatment
EP4351737A4 (en) * 2021-05-24 2025-05-14 Taiho Pharmaceutical Co., Ltd. Treatment methods for subjects with cancer having an aberration in egfr and/or her2
KR20250164828A (ko) 2023-03-30 2025-11-25 레볼루션 메디슨즈, 인크. Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118817A1 (ja) 2012-02-07 2013-08-15 大鵬薬品工業株式会社 キノリルピロロピリミジン化合物又はその塩
WO2017038838A1 (ja) 2015-09-01 2017-03-09 大鵬薬品工業株式会社 新規なピラゾロ［３，４－ｄ］ピリミジン化合物又はその塩
WO2020145374A1 (ja) 2019-01-11 2020-07-16 大鵬薬品工業株式会社 ピリミジン化合物又はその塩

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426428B2 (en) * 2008-12-05 2013-04-23 Principia Biopharma, Inc. EGFR kinase knockdown via electrophilically enhanced inhibitors
US9034885B2 (en) * 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
MD3269370T2 (ro) * 2016-02-23 2020-05-31 Taiho Pharmaceutical Co Ltd Compus pirimidinic condensat nou sau sare a acestuia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118817A1 (ja) 2012-02-07 2013-08-15 大鵬薬品工業株式会社 キノリルピロロピリミジン化合物又はその塩
WO2017038838A1 (ja) 2015-09-01 2017-03-09 大鵬薬品工業株式会社 新規なピラゾロ［３，４－ｄ］ピリミジン化合物又はその塩
WO2020145374A1 (ja) 2019-01-11 2020-07-16 大鵬薬品工業株式会社 ピリミジン化合物又はその塩
JP6783974B1 (ja) 2019-01-11 2020-11-11 大鵬薬品工業株式会社 ピリミジン化合物又はその塩

Also Published As

Publication number Publication date
BR112023000770A2 (pt) 2023-02-07
KR102873219B1 (ko) 2025-10-17
TW202216152A (zh) 2022-05-01
KR20230026451A (ko) 2023-02-24
PH12023550119A1 (en) 2024-06-24
CN116368136B (zh) 2025-09-05
AU2021309779B2 (en) 2024-06-27
JPWO2022014639A1 (enExample) 2022-01-20
EP4197538A4 (en) 2024-08-07
CN116368136A (zh) 2023-06-30
AU2021309779A1 (en) 2023-02-23
MX2023000693A (es) 2023-02-13
US20230285397A1 (en) 2023-09-14
CA3189460A1 (en) 2022-01-20
WO2022014639A1 (ja) 2022-01-20
EP4197538A1 (en) 2023-06-21

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