JP7486415B2 - Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 - Google Patents
Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 Download PDFInfo
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Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
| HUE056489T2 (hu) | 2014-12-19 | 2022-02-28 | Chugai Pharmaceutical Co Ltd | Anti-C5 antitestek és alkalmazási eljárások |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| JP7502865B2 (ja) * | 2017-06-23 | 2024-06-19 | インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
| PL3886820T3 (pl) | 2018-11-30 | 2023-08-14 | Chemocentryx, Inc. | Postacie użytkowe będące kapsułkami |
| CN113543796A (zh) * | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
| WO2020182384A1 (en) | 2019-03-11 | 2020-09-17 | Inflarx Gmbh | Fused piperidinyl bicyclic and related compounds as modulators of c5a receptor |
| US20220211799A1 (en) * | 2019-04-24 | 2022-07-07 | Ra Pharmaceuticals, Inc. | Compositions and methods for modulating complement activity |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| EP4196501A1 (en) * | 2020-08-12 | 2023-06-21 | Innate Pharma | Subcutaneous anti-c5ar antagonist treatment regimen with avdoralimab |
| WO2022093971A1 (en) * | 2020-10-28 | 2022-05-05 | Chemocentryx, Inc. | Methods of treating hidradenitis suppurativa |
| CN116529241A (zh) * | 2020-10-28 | 2023-08-01 | 坎莫森特里克斯公司 | 治疗化脓性汗腺炎的方法 |
| AU2022207985A1 (en) | 2021-01-13 | 2023-07-06 | Visterra, Inc. | Humanized complement 5a receptor 1 antibodies and methods of use thereof |
| CN116036233A (zh) * | 2023-01-10 | 2023-05-02 | 中山大学附属第八医院（深圳福田） | 小分子化合物pmx 53在制备抑制血管钙化和血管纤维化药物中的应用 |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
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| JP2016518331A (ja) | 2013-03-14 | 2016-06-23 | アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 補体成分Ｃ５ｉＲＮＡ組成物及びその使用方法 |
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| WO2020182384A1 (en) | 2019-03-11 | 2020-09-17 | Inflarx Gmbh | Fused piperidinyl bicyclic and related compounds as modulators of c5a receptor |
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| Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ、２０２１年、Ｖｏｌ．１４１、ｐ．２９６６－２９６９ |
| Ｍｏｌｅｃｕｌａｒ Ｍｅｄｉｃｉｎｅ Ｒｅｐｏｒｔｓ、２０１５年２月４日発行、Ｖｏｌ．１１、Ｎｏ．６、ｐ．４１８３－４１８９ |
| Ｎａｔｕｒｅ Ｒｅｖｉｅｗｓ、２０１５年、Ｖｏｌ．１４、ｐ．８５７－８７７ |
| Ｓｔｕｄｙ ＮＣＴ０３００１６２２ ｏｎ Ｄａｔｅ：Ｍａｒｃｈ ２０、２０１７（ｖ３）、Ｃｌｉｎｉｃａｌ Ｔｒｉａｌｓ．ｇｏｖ［ｏｎｌｉｎｅ］、２０１７年３月２０日 |
| 炎症、１９８６年、Ｖｏｌ．６、Ｎｏ．１、ｐ．５－１４ |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022176946A (ja) * | 2017-04-03 | 2022-11-30 | インフラルクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｃ５ａ活性のインヒビターでの炎症性疾患の処置 |
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| JP2022176946A (ja) | 2022-11-30 |
| EP4272821A2 (en) | 2023-11-08 |
| KR20190138806A (ko) | 2019-12-16 |
| EP3411400A1 (en) | 2018-12-12 |
| EP3411400B1 (en) | 2021-09-22 |
| IL261809B1 (en) | 2023-12-01 |
| WO2018184739A1 (en) | 2018-10-11 |
| US20180282425A1 (en) | 2018-10-04 |
| US11273225B2 (en) | 2022-03-15 |
| EP3978523A1 (en) | 2022-04-06 |
| ES2893769T3 (es) | 2022-02-10 |
| IL261809A (en) | 2018-11-29 |
| CL2018002698A1 (es) | 2018-12-07 |
| AU2018249310A1 (en) | 2019-10-17 |
| MX2019011825A (es) | 2020-12-11 |
| JP2020515643A (ja) | 2020-05-28 |
| EP4272821A3 (en) | 2024-01-03 |
| TW202348249A (zh) | 2023-12-16 |
| IL261809B2 (en) | 2024-04-01 |
| ZA201906485B (en) | 2021-08-25 |
| PL3411400T3 (pl) | 2021-12-20 |
| CA3058023A1 (en) | 2018-10-11 |
| DK3411400T3 (da) | 2021-10-11 |
| TW201836641A (zh) | 2018-10-16 |
| TWI826364B (zh) | 2023-12-21 |
| SG11201807998WA (en) | 2018-12-28 |
| CN111108118A (zh) | 2020-05-05 |
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