JP7483331B2 - 光及びグルコサミン塩酸塩を使用して皮膚状態を治療するための組成物及び方法 - Google Patents
光及びグルコサミン塩酸塩を使用して皮膚状態を治療するための組成物及び方法 Download PDFInfo
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- JP7483331B2 JP7483331B2 JP2019119544A JP2019119544A JP7483331B2 JP 7483331 B2 JP7483331 B2 JP 7483331B2 JP 2019119544 A JP2019119544 A JP 2019119544A JP 2019119544 A JP2019119544 A JP 2019119544A JP 7483331 B2 JP7483331 B2 JP 7483331B2
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Description
本発明は、グルコサミン塩酸塩を含む局所適用組成物を利用する。
光送達装置は、赤色光若しくは近赤外光又は両方の任意の光源を含んでもよい。一実施形態では、光送達装置は、光及び近赤外光の両方を送達する。
本発明によると、皮膚に対するグルコサミン塩酸塩の局所投与と赤色光若しくは近赤外光又は両方への曝露との組み合わせは、そのような皮膚によって生成されるヒアルロン酸の予想外の増加をもたらす。そのような組み合わせは、グルコサミン塩酸塩の局所投与又は赤色光及び/若しくは近赤外光への曝露単独のいずれかによって生成される量と比較して、皮膚によって生成されるヒアルロン酸の量の相乗的な増加を提供することが見出された。
ヒアルロン酸の生成に関する以下の試験処置の活性を、未処置試料を対照として使用した上記のインビトロ方法を使用して比較した:a)633nmの赤色光と830nmのIR光との組み合わせ(各々0.3J/cm2)、b)633nmの赤色光と830nmのIR光との組み合わせ(各々3J/cm2)、c)細胞培地溶液中0.02%グルコサミンHCl、d)細胞培地溶液中の0.2%グルコサミンHCl、e)赤色光とIR光との組み合わせ(各々0.3J/cm2)、及び細胞培地溶液中0.02%グルコサミンHClの同時適用、並びにf)赤色光とIR光との組み合わせ(各々3J/cm2)、及び細胞培地溶液中0.2%グルコサミンHClの同時適用。
実施例1と同じ試験方法を使用して、表2に示される処置をヒト皮膚線維芽細胞に適用した。グルコサミン塩酸塩の代わりに、グルコサミンリン酸塩を使用した。
実施例1と同じ試験方法を使用して、表3に示される処置をヒト皮膚線維芽細胞に適用した。グルコサミン塩酸塩の代わりに、N-アセチルグルコサミンを使用した。
水酸化ナトリウムの量を調整することによって、4~5.5の範囲のpH値で表4に示される成分を使用して、グルコサミン塩酸塩を含む局所適用組成物を調製した。5.5を超えるpHを有する組成物は、60℃で7日後又は50℃で30日後に外観及び色について視覚的に評価した場合、物理的に安定ではなかった。
特許請求される発明で使用するための2つの局所適用組成物を、表5及び6に示される成分を使用して調製した。表5の局所適用組成物は、0.1%重量の亜硫酸水素ナトリウムを含有した。表6の局所適用組成物は、亜硫酸水素ナトリウムを含有しなかった。
(1) 皮膚によるヒアルロン酸の生成を増加させる方法であって、最大約2重量%のグルコサミン塩酸塩を含む局所適用組成物をそのような皮膚に局所的に適用することと、光送達装置を使用して、約600nm~約750nmのピーク波長を有する赤色光、約750nm~約1000nmのピーク波長を有する近赤外光、又は両方に前記皮膚を曝露することと、を含む、方法。
(2) 前記皮膚が、前記赤色光及び前記近赤外光の両方に曝露される、実施態様1に記載の方法。
(3) 前記局所適用組成物が、約3.0~約5.5のpHを有する、実施態様1に記載の方法。
(4) 前記光の強度が、約20mW/cm2未満である、実施態様1に記載の方法。
(5) 前記皮膚を超音波エネルギーに曝露することを更に含む、実施態様1に記載の方法。
(7) 皮膚を処置する方法であって、最大約2重量%のグルコサミン塩酸塩を含む局所適用組成物を、皮膚老化の徴候のための治療を必要としている皮膚に局所的に適用することと、光送達装置を使用して、約600nm~約750nmのピーク波長を有する赤色光、約750nm~約1000nmのピーク波長を有する近赤外光、又は両方に前記皮膚を曝露することと、を含む、方法。
(8) 前記皮膚が、前記赤色光及び前記近赤外光の両方に曝露される、実施態様7に記載の方法。
(9) 前記皮膚老化の徴候が、細かい小じわ及びしわである、実施態様7に記載の方法。
(10) 前記局所適用組成物が、約3.0~約5.5のpHを有する、実施態様7に記載の方法。
(12) 前記皮膚を超音波エネルギーに曝露することを更に含む、実施態様7に記載の方法。
(13) 前記光送達装置が、光及び超音波エネルギーを送達する、実施態様12に記載の方法。
(14) 皮膚を処置する方法であって、最大約2重量%のグルコサミン塩酸塩を含む局所適用組成物を、保湿を必要としている皮膚に局所的に適用することと、光送達装置を使用して、約600nm~約750nmのピーク波長を有する赤色光、約750nm~約1000nmのピーク波長を有する近赤外光、又は両方に前記皮膚を曝露することと、を含む、方法。
(15) 前記皮膚が、前記赤色光及び前記近赤外光の両方に曝露される、実施態様14に記載の方法。
(17) 前記局所適用組成物が、約3.0~約5.5のpHを有する、実施態様14に記載の方法。
(18) 前記光の強度が、約20mW/cm2未満である、実施態様14に記載の方法。
(19) 前記皮膚を超音波エネルギーに曝露することを更に含む、実施態様14に記載の方法。
(20) 前記光送達装置が、光及び超音波エネルギーを送達する、実施態様19に記載の方法。
(22) 前記光送達装置が、前記赤色光及び前記近赤外光の両方を送達する、実施態様21に記載のキット。
(23) 約0.1~約2重量%のグルコサミン塩酸塩と、約2.5~約4.5のpKaを有する少なくとも1つの化合物と、を含む、局所適用組成物であって、約5.5未満のpHを有する、局所適用組成物。
(24) 亜硫酸水素ナトリウムを更に含む、実施態様23に記載の組成物。
(25) 前記約2.5~約4.5のpKaを有する化合物が、クエン酸、乳酸、グリコール酸、コハク酸、及びこれらの混合物からなる群から選択される、実施態様23に記載の組成物。
(27) 亜硫酸水素ナトリウムを更に含む、実施態様26に記載のフィルム。
(28) 前記約2.5~約4.5のpKaを有する化合物が、クエン酸、乳酸、グリコール酸、コハク酸、及びこれらの混合物からなる群から選択される、実施態様26に記載のフィルム。
(29) 多層の水で除去することができるフィルムの形態の、実施態様26に記載のフィルム。
(30) グリセリン誘導体を含む下皮膚接触層を含む、実施態様26に記載のフィルム。
Claims (5)
- (a)最大2重量%のグルコサミン塩酸塩を含む局所適用組成物と、(b)600nm~750nmのピーク波長を有する赤色光、750nm~1000nmのピーク波長を有する近赤外光、又は両方を送達する光送達装置と、を含む、キット。
- 前記光送達装置が、前記赤色光及び前記近赤外光の両方を送達する、請求項1に記載のキット。
- 皮膚を処置する方法であって、最大2重量%のグルコサミン塩酸塩を含む局所適用組成物を、皮膚老化の徴候のための処置を必要としている前記皮膚に局所的に適用することと、光送達装置を使用して、600nm~750nmのピーク波長を有する赤色光、750nm~1000nmのピーク波長を有する近赤外光、又は両方に前記皮膚を曝露することと、を含む、方法(但し、ヒトに対する医療行為を除く)。
- 皮膚を処置する方法であって、最大2重量%のグルコサミン塩酸塩を含む局所適用組成物を、保湿を必要としている前記皮膚に局所的に適用することと、光送達装置を使用して、600nm~750nmのピーク波長を有する赤色光、750nm~1000nmのピーク波長を有する近赤外光、又は両方に前記皮膚を曝露することと、を含む、方法(但し、ヒトに対する医療行為を除く)。
- 前記皮膚が、前記赤色光及び前記近赤外光の両方に曝露される、請求項3又は4に記載の方法。
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