JP7483234B2 - Ｈｉｖワクチン免疫原 - Google Patents

Ｈｉｖワクチン免疫原 Download PDF

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Publication number
JP7483234B2
JP7483234B2 JP2021531557A JP2021531557A JP7483234B2 JP 7483234 B2 JP7483234 B2 JP 7483234B2 JP 2021531557 A JP2021531557 A JP 2021531557A JP 2021531557 A JP2021531557 A JP 2021531557A JP 7483234 B2 JP7483234 B2 JP 7483234B2
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Japan
Prior art keywords
polypeptide
subject
glycan
nucleic acid
hiv
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JP2021531557A
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English (en)
Japanese (ja)
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JP2022513438A (ja
JPWO2020117590A5 (https=
JP2022513438A5 (https=
Inventor
ヌーゼンツヴァイク，ミシェル
ビョルクマン，パメラ，ジェイ．
エスコラーノ，アメリア
グリスティック，ハリー
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Rockefeller University
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Rockefeller University
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Publication of JP2022513438A5 publication Critical patent/JP2022513438A5/ja
Priority to JP2024068841A priority Critical patent/JP2024099671A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/112—Retroviridae (F), e.g. leukemia viruses
    • C07K16/114—Lentivirus (G), e.g. human immunodeficiency virus [HIV], feline immunodeficiency virus [FIV] or simian immunodeficiency virus [SIV]
    • C07K16/1145—Env proteins, e.g. gp41, gp110/120, gp160, V3, principal neutralising domain [PND] or CD4-binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111—Leviviridae
    • C12N2795/18123—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021531557A 2018-12-04 2019-11-27 Ｈｉｖワクチン免疫原 Active JP7483234B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024068841A JP2024099671A (ja) 2018-12-04 2024-04-22 Ｈｉｖワクチン免疫原

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862775192P 2018-12-04 2018-12-04
US62/775,192 2018-12-04
PCT/US2019/063619 WO2020117590A1 (en) 2018-12-04 2019-11-27 Hiv vaccine immunogens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024068841A Division JP2024099671A (ja) 2018-12-04 2024-04-22 Ｈｉｖワクチン免疫原

Publications (4)

Publication Number Publication Date
JP2022513438A JP2022513438A (ja) 2022-02-08
JPWO2020117590A5 JPWO2020117590A5 (https=) 2022-11-18
JP2022513438A5 JP2022513438A5 (https=) 2022-11-18
JP7483234B2 true JP7483234B2 (ja) 2024-05-15

Family

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JP2021531557A Active JP7483234B2 (ja) 2018-12-04 2019-11-27 Ｈｉｖワクチン免疫原
JP2024068841A Pending JP2024099671A (ja) 2018-12-04 2024-04-22 Ｈｉｖワクチン免疫原

Family Applications After (1)

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JP2024068841A Pending JP2024099671A (ja) 2018-12-04 2024-04-22 Ｈｉｖワクチン免疫原

Country Status (10)

Country Link
US (2) US12239698B2 (https=)
EP (2) EP3891170B1 (https=)
JP (2) JP7483234B2 (https=)
KR (1) KR20210124205A (https=)
CN (2) CN113454100B (https=)
AU (2) AU2019393745B2 (https=)
CA (1) CA3120324A1 (https=)
ES (1) ES2993834T3 (https=)
PL (1) PL3891170T3 (https=)
WO (1) WO2020117590A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114732898B (zh) * 2022-04-01 2023-05-09 中国人民解放军军事科学院军事医学研究院 一种CpG佐剂与抗原定点共价结合方法
WO2024130122A2 (en) * 2022-12-15 2024-06-20 The Wistar Institute Of Anatomy And Biology Hiv immunogens and methods of using same

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US20140212458A1 (en) 2012-11-05 2014-07-31 International Aids Vaccine Initiative Novel hiv-1 envelope glycoprotein
WO2015134982A1 (en) 2014-03-07 2015-09-11 Cornell University Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers
WO2017165674A1 (en) 2016-03-23 2017-09-28 International Aids Vaccine Initiative Immunogenic trimers
WO2018161049A1 (en) 2017-03-03 2018-09-07 Duke University Compositions and methods for inducing hiv-1 antibodies

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US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
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WO2015134982A1 (en) 2014-03-07 2015-09-11 Cornell University Materials and methods for producing cleaved, hiv-1 envelop glycoprotein trimers
WO2017165674A1 (en) 2016-03-23 2017-09-28 International Aids Vaccine Initiative Immunogenic trimers
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Also Published As

Publication number Publication date
EP3891170A1 (en) 2021-10-13
EP3891170B1 (en) 2024-07-31
WO2020117590A1 (en) 2020-06-11
JP2022513438A (ja) 2022-02-08
CN119241692A (zh) 2025-01-03
ES2993834T3 (en) 2025-01-10
US20250144197A1 (en) 2025-05-08
EP3891170A4 (en) 2022-12-07
CA3120324A1 (en) 2020-06-11
EP4464380A3 (en) 2025-05-07
EP3891170C0 (en) 2024-07-31
US20220031830A1 (en) 2022-02-03
PL3891170T3 (pl) 2024-12-02
JP2024099671A (ja) 2024-07-25
CN113454100A (zh) 2021-09-28
US12239698B2 (en) 2025-03-04
AU2019393745B2 (en) 2025-08-07
KR20210124205A (ko) 2021-10-14
AU2025242201A1 (en) 2026-01-15
CN113454100B (zh) 2024-08-23
EP4464380A2 (en) 2024-11-20
AU2019393745A1 (en) 2021-06-10

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